Bioactive Lysophospholipids and Their G Protein-Coupled Receptors
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce p...
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| Veröffentlicht in: | Experimental cell research 1999-11, Vol.253 (1), p.230-238 |
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| container_title | Experimental cell research |
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| creator | Moolenaar, Wouter H. |
| description | Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated signaling pathways, leading to such diverse responses as cell rounding, neurite retraction, and modulation of tumor cell invasiveness (transcellular migration). A major recent advance is the identification of a subfamily of heptahelical receptors for LPA and S1P. |
| doi_str_mv | 10.1006/excr.1999.4702 |
| format | Article |
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In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated signaling pathways, leading to such diverse responses as cell rounding, neurite retraction, and modulation of tumor cell invasiveness (transcellular migration). A major recent advance is the identification of a subfamily of heptahelical receptors for LPA and S1P.</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1006/excr.1999.4702</identifier><identifier>PMID: 10579925</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cell Division - physiology ; Cytoskeleton - physiology ; Female ; GTP-Binding Proteins - metabolism ; Humans ; Lysophospholipids - metabolism ; Receptors, Cell Surface - metabolism ; Receptors, G-Protein-Coupled ; Receptors, Lysophosphatidic Acid ; Receptors, Lysophospholipid ; Signal Transduction ; Sphingosine - analogs & derivatives ; Sphingosine - metabolism</subject><ispartof>Experimental cell research, 1999-11, Vol.253 (1), p.230-238</ispartof><rights>1999 Academic Press</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-74ebc443373956cddbaa728e3f6bcfd4fcf35b1f954bab4ea93c4cbf9df3cb853</citedby><cites>FETCH-LOGICAL-c340t-74ebc443373956cddbaa728e3f6bcfd4fcf35b1f954bab4ea93c4cbf9df3cb853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001448279994702X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10579925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moolenaar, Wouter H.</creatorcontrib><title>Bioactive Lysophospholipids and Their G Protein-Coupled Receptors</title><title>Experimental cell research</title><addtitle>Exp Cell Res</addtitle><description>Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated signaling pathways, leading to such diverse responses as cell rounding, neurite retraction, and modulation of tumor cell invasiveness (transcellular migration). A major recent advance is the identification of a subfamily of heptahelical receptors for LPA and S1P.</description><subject>Cell Division - physiology</subject><subject>Cytoskeleton - physiology</subject><subject>Female</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Lysophospholipids - metabolism</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Receptors, Lysophosphatidic Acid</subject><subject>Receptors, Lysophospholipid</subject><subject>Signal Transduction</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - metabolism</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtLA0EQgBdRTIy2lnKV3cV93WPLGDQKAUVivexjlqxcsufuXTD_3gtJYWMxTPPNB_MhdEvwlGBcPsCPiVMihJjyCtMzNCZY4JxySs_RGGPCc17TaoSuUvrCGNc1KS_RiOCiEoIWYzR79EGZzu8gW-5TaNchDdP41tuUqa3NVmvwMVtk7zF04Lf5PPRtAzb7AANtF2K6RhdONQluTnuCPp-fVvOXfPm2eJ3PlrlhHHd5xUEbzhmrmChKY61WqqI1MFdq4yx3xrFCEycKrpXmoAQz3GgnrGNG1wWboPujt43hu4fUyY1PBppGbSH0SZaCUVoRNoDTI2hiSCmCk230GxX3kmB5iCYP0eQhmjxEGw7uTuZeb8D-wY-VBqA-AjD8t_MQZTIetgasj2A6aYP_z_0Lxmt9Fw</recordid><startdate>19991125</startdate><enddate>19991125</enddate><creator>Moolenaar, Wouter H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991125</creationdate><title>Bioactive Lysophospholipids and Their G Protein-Coupled Receptors</title><author>Moolenaar, Wouter H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-74ebc443373956cddbaa728e3f6bcfd4fcf35b1f954bab4ea93c4cbf9df3cb853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Cell Division - physiology</topic><topic>Cytoskeleton - physiology</topic><topic>Female</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Lysophospholipids - metabolism</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Receptors, Lysophosphatidic Acid</topic><topic>Receptors, Lysophospholipid</topic><topic>Signal Transduction</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moolenaar, Wouter H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moolenaar, Wouter H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Lysophospholipids and Their G Protein-Coupled Receptors</atitle><jtitle>Experimental cell research</jtitle><addtitle>Exp Cell Res</addtitle><date>1999-11-25</date><risdate>1999</risdate><volume>253</volume><issue>1</issue><spage>230</spage><epage>238</epage><pages>230-238</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. 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| fulltext | fulltext |
| identifier | ISSN: 0014-4827 |
| ispartof | Experimental cell research, 1999-11, Vol.253 (1), p.230-238 |
| issn | 0014-4827 1090-2422 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cell Division - physiology Cytoskeleton - physiology Female GTP-Binding Proteins - metabolism Humans Lysophospholipids - metabolism Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Lysophosphatidic Acid Receptors, Lysophospholipid Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism |
| title | Bioactive Lysophospholipids and Their G Protein-Coupled Receptors |
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