IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children
A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic. Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant protein fragments of Plasmodium falciparum Rhoptry-Associated Prot...
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| Veröffentlicht in: | Parasitology 1999-10, Vol.119 (4), p.337-342 |
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| creator | ALIFRANGIS, M. LEMNGE, M. M. MOON, R. THEISEN, M. BYGBJERG, I. RIDLEY, R. G. JAKOBSEN, P. H. |
| description | A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic.
Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant
protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The data were related to the
prevalence of malarial disease and single P. falciparum or mixed Plasmodium infections. Fever ([ges ]37·5 °C) in combination
with parasite densities >5000/μl were used to distinguish between children with asymptomatic malaria infections and
those with acute clinical disease. Furthermore, C-reactive protein (CRP) was applied as a surrogate marker of malaria
morbidity. The prevalence of Plasmodium infections was 96·0%. Eleven children were defined as clinical malaria cases,
all with single P. falciparum infections. The density of P. falciparum was significantly lower in children with mixed
Plasmodium infections compared to those with single P. falciparum infections. Children with asymptomatic P. falciparum
infections had higher IgG reactivities to rRAP-1, compared to IgG reactivities of children with malarial disease. Children
with mixed Plasmodium infections generally showed elevated IgG reactivity to rRAP-1, when compared to children with
single P. falciparum infections. The possible relationship between mixed species infections, clinical outcome of the disease
and antibody responses to RAP-1 is discussed. |
| doi_str_mv | 10.1017/S0031182099004825 |
| format | Article |
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Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant
protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The data were related to the
prevalence of malarial disease and single P. falciparum or mixed Plasmodium infections. Fever ([ges ]37·5 °C) in combination
with parasite densities >5000/μl were used to distinguish between children with asymptomatic malaria infections and
those with acute clinical disease. Furthermore, C-reactive protein (CRP) was applied as a surrogate marker of malaria
morbidity. The prevalence of Plasmodium infections was 96·0%. Eleven children were defined as clinical malaria cases,
all with single P. falciparum infections. The density of P. falciparum was significantly lower in children with mixed
Plasmodium infections compared to those with single P. falciparum infections. Children with asymptomatic P. falciparum
infections had higher IgG reactivities to rRAP-1, compared to IgG reactivities of children with malarial disease. Children
with mixed Plasmodium infections generally showed elevated IgG reactivity to rRAP-1, when compared to children with
single P. falciparum infections. The possible relationship between mixed species infections, clinical outcome of the disease
and antibody responses to RAP-1 is discussed.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S0031182099004825</identifier><identifier>PMID: 10581610</identifier><identifier>CODEN: PARAAE</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Age Factors ; Animals ; Antibodies, Protozoan - blood ; Biological and medical sciences ; C-reactive protein ; C-Reactive Protein - analysis ; Child, Preschool ; Cross-Sectional Studies ; Endemic Diseases ; Human protozoal diseases ; Humans ; Immunoglobulin G - blood ; Infant ; Infectious diseases ; Malaria ; Malaria - blood ; Malaria - epidemiology ; Malaria - immunology ; Malaria, Falciparum - blood ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Medical sciences ; mixed species infections ; Morbidity ; Parasitemia ; Parasitic diseases ; Plasmodium falciparum ; Plasmodium malariae - immunology ; Protozoal diseases ; Protozoan Proteins - immunology ; Rhoptry-associated protein-1 ; rRAP-1 protein ; Species Specificity ; Tanzania ; Tanzania - epidemiology ; Tropical medicine</subject><ispartof>Parasitology, 1999-10, Vol.119 (4), p.337-342</ispartof><rights>1999 Cambridge University Press</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-f619c83987c7c57247639ecb5bc764a0e2d4645efb795c959de3e5f490d0a7fb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0031182099004825/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1967541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10581610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALIFRANGIS, M.</creatorcontrib><creatorcontrib>LEMNGE, M. M.</creatorcontrib><creatorcontrib>MOON, R.</creatorcontrib><creatorcontrib>THEISEN, M.</creatorcontrib><creatorcontrib>BYGBJERG, I.</creatorcontrib><creatorcontrib>RIDLEY, R. G.</creatorcontrib><creatorcontrib>JAKOBSEN, P. H.</creatorcontrib><title>IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic.
Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant
protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The data were related to the
prevalence of malarial disease and single P. falciparum or mixed Plasmodium infections. Fever ([ges ]37·5 °C) in combination
with parasite densities >5000/μl were used to distinguish between children with asymptomatic malaria infections and
those with acute clinical disease. Furthermore, C-reactive protein (CRP) was applied as a surrogate marker of malaria
morbidity. The prevalence of Plasmodium infections was 96·0%. Eleven children were defined as clinical malaria cases,
all with single P. falciparum infections. The density of P. falciparum was significantly lower in children with mixed
Plasmodium infections compared to those with single P. falciparum infections. Children with asymptomatic P. falciparum
infections had higher IgG reactivities to rRAP-1, compared to IgG reactivities of children with malarial disease. Children
with mixed Plasmodium infections generally showed elevated IgG reactivity to rRAP-1, when compared to children with
single P. falciparum infections. The possible relationship between mixed species infections, clinical outcome of the disease
and antibody responses to RAP-1 is discussed.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antibodies, Protozoan - blood</subject><subject>Biological and medical sciences</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Endemic Diseases</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria - blood</subject><subject>Malaria - epidemiology</subject><subject>Malaria - immunology</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Medical sciences</subject><subject>mixed species infections</subject><subject>Morbidity</subject><subject>Parasitemia</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium malariae - immunology</subject><subject>Protozoal diseases</subject><subject>Protozoan Proteins - immunology</subject><subject>Rhoptry-associated protein-1</subject><subject>rRAP-1 protein</subject><subject>Species Specificity</subject><subject>Tanzania</subject><subject>Tanzania - epidemiology</subject><subject>Tropical medicine</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURSMEokPhA9ggL1AFi4Adx3a8HLUwVKqglEFCbKwX52XGJXEG2wMtP8UvkjCjFgkJVpZ9z7v3yi_LHjP6glGmXn6glDNWFVRrSsuqEHeyGSulzism2d1sNsn5pB9kD2K8pJRKLov72QGjYkLoLPt5ulqQgGCT--aSw0hgBc7HND7aoa-dB5_IxXrYpHCdz2McrIOEDTkPQ0Lnc0aehYv5ec6eEwhI4Jb47tKa9O5qgjuI_dC4bU-cb3EMG_yY5BuymWx-32-CGxcRIo4kWYL_Ad6BJ3btuiagf5jda6GL-Gh_HmYfX79aHr_Jz94tTo_nZ7ktuU55K5m2FdeVssoKVZRKco22FrVVsgSKRVPKUmBbKy2sFrpBjqItNW0oqLbmh9nRzncs-HWLMZneRYtdBx6HbTRS86KQkv0XZKpkoirKEWQ70IYhxoCt2QTXQ7g2jJppneavdY4zT_bm27rH5o-J3f5G4OkegGihawN46-Itp6US5VQy32EuJry6kSF8MVJxJYxcvDdvP3-q-MnyxEy2fN8V-jq4ZoXmctgGP_74P9r-AjbAyFg</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>ALIFRANGIS, M.</creator><creator>LEMNGE, M. M.</creator><creator>MOON, R.</creator><creator>THEISEN, M.</creator><creator>BYGBJERG, I.</creator><creator>RIDLEY, R. G.</creator><creator>JAKOBSEN, P. H.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children</title><author>ALIFRANGIS, M. ; LEMNGE, M. M. ; MOON, R. ; THEISEN, M. ; BYGBJERG, I. ; RIDLEY, R. G. ; JAKOBSEN, P. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-f619c83987c7c57247639ecb5bc764a0e2d4645efb795c959de3e5f490d0a7fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Antibodies, Protozoan - blood</topic><topic>Biological and medical sciences</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Endemic Diseases</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria - blood</topic><topic>Malaria - epidemiology</topic><topic>Malaria - immunology</topic><topic>Malaria, Falciparum - blood</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Medical sciences</topic><topic>mixed species infections</topic><topic>Morbidity</topic><topic>Parasitemia</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium malariae - immunology</topic><topic>Protozoal diseases</topic><topic>Protozoan Proteins - immunology</topic><topic>Rhoptry-associated protein-1</topic><topic>rRAP-1 protein</topic><topic>Species Specificity</topic><topic>Tanzania</topic><topic>Tanzania - epidemiology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALIFRANGIS, M.</creatorcontrib><creatorcontrib>LEMNGE, M. M.</creatorcontrib><creatorcontrib>MOON, R.</creatorcontrib><creatorcontrib>THEISEN, M.</creatorcontrib><creatorcontrib>BYGBJERG, I.</creatorcontrib><creatorcontrib>RIDLEY, R. G.</creatorcontrib><creatorcontrib>JAKOBSEN, P. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALIFRANGIS, M.</au><au>LEMNGE, M. M.</au><au>MOON, R.</au><au>THEISEN, M.</au><au>BYGBJERG, I.</au><au>RIDLEY, R. G.</au><au>JAKOBSEN, P. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>119</volume><issue>4</issue><spage>337</spage><epage>342</epage><pages>337-342</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><coden>PARAAE</coden><abstract>A cross-sectional sero-epidemiological study was performed in Magoda, Tanzania, an area where malaria is holoendemic.
Blood samples were collected from children (1–4 years) and tested for IgG antibody reactivity against 2 recombinant
protein fragments of Plasmodium falciparum Rhoptry-Associated Protein-1 (rRAP-1). The data were related to the
prevalence of malarial disease and single P. falciparum or mixed Plasmodium infections. Fever ([ges ]37·5 °C) in combination
with parasite densities >5000/μl were used to distinguish between children with asymptomatic malaria infections and
those with acute clinical disease. Furthermore, C-reactive protein (CRP) was applied as a surrogate marker of malaria
morbidity. The prevalence of Plasmodium infections was 96·0%. Eleven children were defined as clinical malaria cases,
all with single P. falciparum infections. The density of P. falciparum was significantly lower in children with mixed
Plasmodium infections compared to those with single P. falciparum infections. Children with asymptomatic P. falciparum
infections had higher IgG reactivities to rRAP-1, compared to IgG reactivities of children with malarial disease. Children
with mixed Plasmodium infections generally showed elevated IgG reactivity to rRAP-1, when compared to children with
single P. falciparum infections. The possible relationship between mixed species infections, clinical outcome of the disease
and antibody responses to RAP-1 is discussed.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10581610</pmid><doi>10.1017/S0031182099004825</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Parasitology, 1999-10, Vol.119 (4), p.337-342 |
| issn | 0031-1820 1469-8161 |
| language | eng |
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| source | MEDLINE; Cambridge Journals |
| subjects | Age Factors Animals Antibodies, Protozoan - blood Biological and medical sciences C-reactive protein C-Reactive Protein - analysis Child, Preschool Cross-Sectional Studies Endemic Diseases Human protozoal diseases Humans Immunoglobulin G - blood Infant Infectious diseases Malaria Malaria - blood Malaria - epidemiology Malaria - immunology Malaria, Falciparum - blood Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Medical sciences mixed species infections Morbidity Parasitemia Parasitic diseases Plasmodium falciparum Plasmodium malariae - immunology Protozoal diseases Protozoan Proteins - immunology Rhoptry-associated protein-1 rRAP-1 protein Species Specificity Tanzania Tanzania - epidemiology Tropical medicine |
| title | IgG reactivities against recombinant Rhoptry-Associated Protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children |
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