MAD2 Interacts with DNA Repair Proteins and Negatively Regulates DNA Damage Repair

MAD2 (mitotic arrest deficient 2) is a key regulator of mitosis. Recently, it had been suggested that MAD2-induced mitotic arrest mediates DNA damage response and that upregulation of MAD2 confers sensitivity to DNA-damaging anticancer drug-induced apoptosis. In this study, we report a potential nov...

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Veröffentlicht in:	Journal of molecular biology 2008-08, Vol.381 (1), p.24-34
Hauptverfasser:	Fung, Maggie K.L., Han, Hui-Ying, Leung, Steve C.L., Cheung, Hiu Wing, Cheung, Annie L.M., Wong, Yong-Chuan, Ling, Ming-Tat, Wang, Xianghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cisplatin - pharmacology DNA - genetics DNA - metabolism DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - drug effects Histones - metabolism Humans MAD2 Mad2 Proteins Protein Binding Rad51 Recombinase - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Xeroderma Pigmentosum Group D Protein - metabolism
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