Mutations in ELA2 , encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis

Human cyclic haematopoiesis (cyclic neutropenia, MIM 162800) is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individ...

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