Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
This 2-year trial, which took place in an isolated workplace that facilitated retention in the study, randomly assigned 322 moderately obese subjects to one of three diets: a low-fat, restricted-calorie diet; a Mediterranean, restricted-calorie diet; or a low-carbohydrate, non–restricted-calorie die...
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| Veröffentlicht in: | The New England journal of medicine 2008-07, Vol.359 (3), p.229-241 |
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| creator | Shai, Iris Schwarzfuchs, Dan Henkin, Yaakov Shahar, Danit R Witkow, Shula Greenberg, Ilana Golan, Rachel Fraser, Drora Bolotin, Arkady Vardi, Hilel Tangi-Rozental, Osnat Zuk-Ramot, Rachel Sarusi, Benjamin Brickner, Dov Schwartz, Ziva Sheiner, Einat Marko, Rachel Katorza, Esther Thiery, Joachim Fiedler, Georg Martin Blüher, Matthias Stumvoll, Michael Stampfer, Meir J |
| description | This 2-year trial, which took place in an isolated workplace that facilitated retention in the study, randomly assigned 322 moderately obese subjects to one of three diets: a low-fat, restricted-calorie diet; a Mediterranean, restricted-calorie diet; or a low-carbohydrate, non–restricted-calorie diet. The results suggest that the Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
This study suggests that Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
The dramatic increase in obesity worldwide remains challenging and underscores the urgent need to test the effectiveness and safety of several widely used weight-loss diets.
1
–
3
Low-carbohydrate, high-protein, high-fat diets (referred to as low-carbohydrate diets) have been compared with low-fat, energy-restricted diets.
4
–
9
A meta-analysis of five trials with 447 participants
10
and a recent 1-year trial involving 311 obese women
4
suggested that a low-carbohydrate diet is a feasible alternative to a low-fat diet for producing weight loss and may have favorable metabolic effects. However, longer-term studies are lacking.
4
,
10
A Mediterranean diet with a moderate amount of fat and a . . . |
| doi_str_mv | 10.1056/NEJMoa0708681 |
| format | Article |
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This study suggests that Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
The dramatic increase in obesity worldwide remains challenging and underscores the urgent need to test the effectiveness and safety of several widely used weight-loss diets.
1
–
3
Low-carbohydrate, high-protein, high-fat diets (referred to as low-carbohydrate diets) have been compared with low-fat, energy-restricted diets.
4
–
9
A meta-analysis of five trials with 447 participants
10
and a recent 1-year trial involving 311 obese women
4
suggested that a low-carbohydrate diet is a feasible alternative to a low-fat diet for producing weight loss and may have favorable metabolic effects. However, longer-term studies are lacking.
4
,
10
A Mediterranean diet with a moderate amount of fat and a . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa0708681</identifier><identifier>PMID: 18635428</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - analysis ; Body Mass Index ; Carbohydrates ; Cardiovascular disease ; Diet ; Diet, Carbohydrate-Restricted ; Diet, Fat-Restricted ; Diet, Mediterranean ; Dietitians ; Energy Intake ; Female ; Follow-Up Studies ; General aspects ; Glycated Hemoglobin A - analysis ; Health maintenance organizations ; HMOs ; Humans ; Ketones - urine ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; Obesity - blood ; Obesity - diet therapy ; Obesity - urine ; Surveys and Questionnaires ; Weight control ; Weight Loss</subject><ispartof>The New England journal of medicine, 2008-07, Vol.359 (3), p.229-241</ispartof><rights>Copyright © 2008 Massachusetts Medical Society. All rights reserved.</rights><rights>2008 INIST-CNRS</rights><rights>2008 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-51f4b5fbaa5ec44228777d35a13d4642188e7777847da69dffc5cab1fa973a813</citedby><cites>FETCH-LOGICAL-c548t-51f4b5fbaa5ec44228777d35a13d4642188e7777847da69dffc5cab1fa973a813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa0708681$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa0708681$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20516926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18635428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shai, Iris</creatorcontrib><creatorcontrib>Schwarzfuchs, Dan</creatorcontrib><creatorcontrib>Henkin, Yaakov</creatorcontrib><creatorcontrib>Shahar, Danit R</creatorcontrib><creatorcontrib>Witkow, Shula</creatorcontrib><creatorcontrib>Greenberg, Ilana</creatorcontrib><creatorcontrib>Golan, Rachel</creatorcontrib><creatorcontrib>Fraser, Drora</creatorcontrib><creatorcontrib>Bolotin, Arkady</creatorcontrib><creatorcontrib>Vardi, Hilel</creatorcontrib><creatorcontrib>Tangi-Rozental, Osnat</creatorcontrib><creatorcontrib>Zuk-Ramot, Rachel</creatorcontrib><creatorcontrib>Sarusi, Benjamin</creatorcontrib><creatorcontrib>Brickner, Dov</creatorcontrib><creatorcontrib>Schwartz, Ziva</creatorcontrib><creatorcontrib>Sheiner, Einat</creatorcontrib><creatorcontrib>Marko, Rachel</creatorcontrib><creatorcontrib>Katorza, Esther</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Fiedler, Georg Martin</creatorcontrib><creatorcontrib>Blüher, Matthias</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Stampfer, Meir J</creatorcontrib><creatorcontrib>Dietary Intervention Randomized Controlled Trial (DIRECT) Group</creatorcontrib><title>Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This 2-year trial, which took place in an isolated workplace that facilitated retention in the study, randomly assigned 322 moderately obese subjects to one of three diets: a low-fat, restricted-calorie diet; a Mediterranean, restricted-calorie diet; or a low-carbohydrate, non–restricted-calorie diet. The results suggest that the Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
This study suggests that Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
The dramatic increase in obesity worldwide remains challenging and underscores the urgent need to test the effectiveness and safety of several widely used weight-loss diets.
1
–
3
Low-carbohydrate, high-protein, high-fat diets (referred to as low-carbohydrate diets) have been compared with low-fat, energy-restricted diets.
4
–
9
A meta-analysis of five trials with 447 participants
10
and a recent 1-year trial involving 311 obese women
4
suggested that a low-carbohydrate diet is a feasible alternative to a low-fat diet for producing weight loss and may have favorable metabolic effects. However, longer-term studies are lacking.
4
,
10
A Mediterranean diet with a moderate amount of fat and a . . .</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Carbohydrates</subject><subject>Cardiovascular disease</subject><subject>Diet</subject><subject>Diet, Carbohydrate-Restricted</subject><subject>Diet, Fat-Restricted</subject><subject>Diet, Mediterranean</subject><subject>Dietitians</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Health maintenance organizations</subject><subject>HMOs</subject><subject>Humans</subject><subject>Ketones - urine</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - diet therapy</subject><subject>Obesity - 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blood</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Carbohydrates</topic><topic>Cardiovascular disease</topic><topic>Diet</topic><topic>Diet, Carbohydrate-Restricted</topic><topic>Diet, Fat-Restricted</topic><topic>Diet, Mediterranean</topic><topic>Dietitians</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Health maintenance organizations</topic><topic>HMOs</topic><topic>Humans</topic><topic>Ketones - urine</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - diet therapy</topic><topic>Obesity - urine</topic><topic>Surveys and Questionnaires</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shai, Iris</creatorcontrib><creatorcontrib>Schwarzfuchs, Dan</creatorcontrib><creatorcontrib>Henkin, Yaakov</creatorcontrib><creatorcontrib>Shahar, Danit R</creatorcontrib><creatorcontrib>Witkow, Shula</creatorcontrib><creatorcontrib>Greenberg, Ilana</creatorcontrib><creatorcontrib>Golan, Rachel</creatorcontrib><creatorcontrib>Fraser, Drora</creatorcontrib><creatorcontrib>Bolotin, Arkady</creatorcontrib><creatorcontrib>Vardi, Hilel</creatorcontrib><creatorcontrib>Tangi-Rozental, Osnat</creatorcontrib><creatorcontrib>Zuk-Ramot, Rachel</creatorcontrib><creatorcontrib>Sarusi, Benjamin</creatorcontrib><creatorcontrib>Brickner, Dov</creatorcontrib><creatorcontrib>Schwartz, Ziva</creatorcontrib><creatorcontrib>Sheiner, Einat</creatorcontrib><creatorcontrib>Marko, Rachel</creatorcontrib><creatorcontrib>Katorza, Esther</creatorcontrib><creatorcontrib>Thiery, Joachim</creatorcontrib><creatorcontrib>Fiedler, Georg Martin</creatorcontrib><creatorcontrib>Blüher, Matthias</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Stampfer, Meir J</creatorcontrib><creatorcontrib>Dietary Intervention Randomized Controlled Trial (DIRECT) Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shai, Iris</au><au>Schwarzfuchs, Dan</au><au>Henkin, Yaakov</au><au>Shahar, Danit R</au><au>Witkow, Shula</au><au>Greenberg, Ilana</au><au>Golan, Rachel</au><au>Fraser, Drora</au><au>Bolotin, Arkady</au><au>Vardi, Hilel</au><au>Tangi-Rozental, Osnat</au><au>Zuk-Ramot, Rachel</au><au>Sarusi, Benjamin</au><au>Brickner, Dov</au><au>Schwartz, Ziva</au><au>Sheiner, Einat</au><au>Marko, Rachel</au><au>Katorza, Esther</au><au>Thiery, Joachim</au><au>Fiedler, Georg Martin</au><au>Blüher, Matthias</au><au>Stumvoll, Michael</au><au>Stampfer, Meir J</au><aucorp>Dietary Intervention Randomized Controlled Trial (DIRECT) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2008-07-17</date><risdate>2008</risdate><volume>359</volume><issue>3</issue><spage>229</spage><epage>241</epage><pages>229-241</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>This 2-year trial, which took place in an isolated workplace that facilitated retention in the study, randomly assigned 322 moderately obese subjects to one of three diets: a low-fat, restricted-calorie diet; a Mediterranean, restricted-calorie diet; or a low-carbohydrate, non–restricted-calorie diet. The results suggest that the Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
This study suggests that Mediterranean and low-carbohydrate diets are effective alternatives to low-fat diets and that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.
The dramatic increase in obesity worldwide remains challenging and underscores the urgent need to test the effectiveness and safety of several widely used weight-loss diets.
1
–
3
Low-carbohydrate, high-protein, high-fat diets (referred to as low-carbohydrate diets) have been compared with low-fat, energy-restricted diets.
4
–
9
A meta-analysis of five trials with 447 participants
10
and a recent 1-year trial involving 311 obese women
4
suggested that a low-carbohydrate diet is a feasible alternative to a low-fat diet for producing weight loss and may have favorable metabolic effects. However, longer-term studies are lacking.
4
,
10
A Mediterranean diet with a moderate amount of fat and a . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>18635428</pmid><doi>10.1056/NEJMoa0708681</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Biological and medical sciences Biomarkers - blood Blood Glucose - analysis Body Mass Index Carbohydrates Cardiovascular disease Diet Diet, Carbohydrate-Restricted Diet, Fat-Restricted Diet, Mediterranean Dietitians Energy Intake Female Follow-Up Studies General aspects Glycated Hemoglobin A - analysis Health maintenance organizations HMOs Humans Ketones - urine Lipids - blood Male Medical sciences Middle Aged Obesity - blood Obesity - diet therapy Obesity - urine Surveys and Questionnaires Weight control Weight Loss |
| title | Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet |
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