Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal

JAK2 and MPL mutations are recurrent in myeloproliferative neoplasms (MPNs). A JAK2 mutation, primarily JAK2 V617F, is almost invariably associated with polycythemia vera (PV). However, JAK2 V617F also occurs in the majority of patients with essential thrombocythemia (ET) or primary myelofibrosis (P...

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Veröffentlicht in:	Leukemia 2008-07, Vol.22 (7), p.1299-1307
Hauptverfasser:	Vannucchi, A M, Antonioli, E, Guglielmelli, P, Pardanani, A, Tefferi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antigens, CD34 - analysis Blood cancer Cancer Research Correlation Critical Care Medicine Cytokines Genotype Genotypes Granulocytes Hematology Heterozygote Homozygote Intensive Internal Medicine Janus kinase 2 Janus Kinase 2 - genetics Kinases Leukemia Literature reviews Medicine Medicine & Public Health Mutation Myelofibrosis Myeloproliferative Disorders - genetics Neoplasms Oncology Patients Phenotype Phenotypes Polycythemia Polycythemia vera Polycythemia Vera - genetics Primary Myelofibrosis - genetics spotlight-review Thrombocythemia, Essential - genetics Tumors
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