The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

The crystal structure of the complex formed between the antimalarial drug halofantrine and ferriprotoporphyrin IX (Fe(III)PPIX) has been determined by single crystal X-ray diffraction. The structure shows that halofantrine coordinates to the Fe(III) center through its alcohol functionality in additi...

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Veröffentlicht in:	Journal of inorganic biochemistry 2008-08, Vol.102 (8), p.1660-1667
Hauptverfasser:	de Villiers, Katherine A., Marques, Helder M., Egan, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Antimalarials Antimalarials - chemistry Binding Sites Crystal structure Crystallography, X-Ray Halofantrine Heme Hemin - chemistry Malaria Molecular Structure Phenanthrenes - chemistry Quinidine Quinine
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