Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry
Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by por...
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| Veröffentlicht in: | Analytica chimica acta 2008-08, Vol.623 (2), p.178-186 |
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| container_title | Analytica chimica acta |
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| creator | Ricci, Camilla Nyadong, Leonard Yang, Felicia Fernandez, Facundo M. Brown, Christopher D. Newton, Paul N. Kazarian, Sergei G. |
| description | Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan™) for the
in situ chemical identification of counterfeit tablets is reported. |
| doi_str_mv | 10.1016/j.aca.2008.06.007 |
| format | Article |
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| subjects | Analytical chemistry Antimalarials - analysis Artemisinins - analysis Chemistry Counterfeit drugs Desorption electrospray ionization Direct analysis in real-time Exact sciences and technology Fourier Analysis Fraud General, instrumentation Malaria Mass spectrometry Mass Spectrometry - methods Portable Raman spectroscopy Quality Control Reproducibility of Results Spectrometric and optical methods Spectrum Analysis, Raman - instrumentation Tablets |
| title | Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry |
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