Inhibition of Cathepsin L by Epoxysuccinyl Peptides Simultaneously Addressing Active-Site and Remote-Site Regions

The propeptide domain as structural guide: Based on information provided by the cathepsin L prodomain, a remote‐site region was identified and exploited to improve the affinity/selectivity profile of irreversible cathepsin L inhibitors.

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2008-07, Vol.9 (11), p.1721-1724
Hauptverfasser: Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Machleidt, Werner
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Sprache:eng
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