Isoform of Fibronectin Mediates Bone Loss in Patients With Primary Biliary Cirrhosis by Suppressing Bone Formation

Osteoporosis is a major cause of morbidity and decreased quality of life in patients with chronic cholestatic liver disease. It is established that this osteoporosis results from decreased bone formation, but the mechanisms for the interaction between liver and bone remain elusive. The aim of this s...

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Veröffentlicht in:	Journal of bone and mineral research 2008-08, Vol.23 (8), p.1278-1286
Hauptverfasser:	Kawelke, Nina, Bentmann, Anke, Hackl, Norman, Hager, Hans‐Dieter, Feick, Peter, Geursen, Anne, Singer, Manfred V, Nakchbandi, Inaam A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid - metabolism Animals Biological and medical sciences Biomarkers - blood Bone Density - drug effects bone formation bone loss Bone Resorption - complications Bone Resorption - physiopathology Calcification, Physiologic - drug effects Cells, Cultured Female fibronectin Fibronectins - administration & dosage Fibronectins - blood Fibronectins - metabolism Fibronectins - pharmacology Fundamental and applied biological sciences. Psychology Humans Injections, Intraperitoneal Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - physiopathology Male Mice Middle Aged osteoblast Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin - metabolism Osteogenesis - drug effects primary biliary cirrhosis Protein Isoforms - blood Protein Isoforms - metabolism Skeleton and joints Tibia - drug effects Tibia - metabolism Vertebrates: osteoarticular system, musculoskeletal system
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