D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis
Side reactions side‐stepped: A D‐amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L‐amino acid specific enzymes ar...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-07, Vol.47 (29), p.5456-5460 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5460 |
|---|---|
| container_issue | 29 |
| container_start_page | 5456 |
| container_title | Angewandte Chemie (International ed.) |
| container_volume | 47 |
| creator | Wehofsky, Nicole Pech, Andreas Liebscher, Sandra Schmidt, Stephanie Komeda, Hidenobu Asano, Yasuhisa Bordusa, Frank |
| description | Side reactions side‐stepped: A D‐amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L‐amino acid specific enzymes are avoided in this approach. |
| doi_str_mv | 10.1002/anie.200800340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69316346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69316346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4710-e06362e85d2f2872ca3916045e17dc2e032a31285f4b0d7b768f5976542396653</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERUvhyhF84pZlbMcf4RYt3bbSalu0FI6WN5mAIXGWOFvYf1-XrEpvPc1I87yvRg8hbxjMGAD_4ILHGQcwACKHZ-SESc4yobV4nvZciEwbyY7Jyxh_Jt4YUC_IMTNSMmXMCcFPWdn50NOy8jVdb7Hyja_o9dCP6CJG6kJNV270t0jLts2W2b-TD_EjLem8D7eYPghjWruNDwnsA236ga6x83Efxh8YfXxFjhrXRnx9mKfkZnH2ZX6RLa_OL-flMqtyzSBDUEJxNLLmDTeaV04UTEEukem64giCO8G4kU2-gVpvtDKNLLSSOReFUlKckvdT73bof-8wjjY9UWHbuoD9LlpVCKZErhI4m8Bq6GMcsLHbwXdu2FsG9l6svRdrH8SmwNtD827TYf0fP5hMQDEBf3yL-yfqbLm6PHtcnk1ZH0f8-5B1wy-rtNDSflud2-v8q17A54XliX838Y3rrfs--Ghv1hyYAEi-dMHFHWP6mxY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69316346</pqid></control><display><type>article</type><title>D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Wehofsky, Nicole ; Pech, Andreas ; Liebscher, Sandra ; Schmidt, Stephanie ; Komeda, Hidenobu ; Asano, Yasuhisa ; Bordusa, Frank</creator><creatorcontrib>Wehofsky, Nicole ; Pech, Andreas ; Liebscher, Sandra ; Schmidt, Stephanie ; Komeda, Hidenobu ; Asano, Yasuhisa ; Bordusa, Frank</creatorcontrib><description>Side reactions side‐stepped: A D‐amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L‐amino acid specific enzymes are avoided in this approach.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.200800340</identifier><identifier>PMID: 18551688</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Amino Acids ; Biomimetic Materials ; Escherichia coli Proteins - chemical synthesis ; Methods ; Peptide Hydrolases - metabolism ; peptide ligation ; Peptides - chemical synthesis ; Peptidylprolyl Isomerase - chemical synthesis ; proteases ; protein semisynthesis ; Proteins - chemical synthesis ; substrate mimetics</subject><ispartof>Angewandte Chemie (International ed.), 2008-07, Vol.47 (29), p.5456-5460</ispartof><rights>Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4710-e06362e85d2f2872ca3916045e17dc2e032a31285f4b0d7b768f5976542396653</citedby><cites>FETCH-LOGICAL-c4710-e06362e85d2f2872ca3916045e17dc2e032a31285f4b0d7b768f5976542396653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.200800340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.200800340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18551688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wehofsky, Nicole</creatorcontrib><creatorcontrib>Pech, Andreas</creatorcontrib><creatorcontrib>Liebscher, Sandra</creatorcontrib><creatorcontrib>Schmidt, Stephanie</creatorcontrib><creatorcontrib>Komeda, Hidenobu</creatorcontrib><creatorcontrib>Asano, Yasuhisa</creatorcontrib><creatorcontrib>Bordusa, Frank</creatorcontrib><title>D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis</title><title>Angewandte Chemie (International ed.)</title><addtitle>Angewandte Chemie International Edition</addtitle><description>Side reactions side‐stepped: A D‐amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L‐amino acid specific enzymes are avoided in this approach.</description><subject>Amino Acids</subject><subject>Biomimetic Materials</subject><subject>Escherichia coli Proteins - chemical synthesis</subject><subject>Methods</subject><subject>Peptide Hydrolases - metabolism</subject><subject>peptide ligation</subject><subject>Peptides - chemical synthesis</subject><subject>Peptidylprolyl Isomerase - chemical synthesis</subject><subject>proteases</subject><subject>protein semisynthesis</subject><subject>Proteins - chemical synthesis</subject><subject>substrate mimetics</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERUvhyhF84pZlbMcf4RYt3bbSalu0FI6WN5mAIXGWOFvYf1-XrEpvPc1I87yvRg8hbxjMGAD_4ILHGQcwACKHZ-SESc4yobV4nvZciEwbyY7Jyxh_Jt4YUC_IMTNSMmXMCcFPWdn50NOy8jVdb7Hyja_o9dCP6CJG6kJNV270t0jLts2W2b-TD_EjLem8D7eYPghjWruNDwnsA236ga6x83Efxh8YfXxFjhrXRnx9mKfkZnH2ZX6RLa_OL-flMqtyzSBDUEJxNLLmDTeaV04UTEEukem64giCO8G4kU2-gVpvtDKNLLSSOReFUlKckvdT73bof-8wjjY9UWHbuoD9LlpVCKZErhI4m8Bq6GMcsLHbwXdu2FsG9l6svRdrH8SmwNtD827TYf0fP5hMQDEBf3yL-yfqbLm6PHtcnk1ZH0f8-5B1wy-rtNDSflud2-v8q17A54XliX838Y3rrfs--Ghv1hyYAEi-dMHFHWP6mxY</recordid><startdate>20080707</startdate><enddate>20080707</enddate><creator>Wehofsky, Nicole</creator><creator>Pech, Andreas</creator><creator>Liebscher, Sandra</creator><creator>Schmidt, Stephanie</creator><creator>Komeda, Hidenobu</creator><creator>Asano, Yasuhisa</creator><creator>Bordusa, Frank</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080707</creationdate><title>D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis</title><author>Wehofsky, Nicole ; Pech, Andreas ; Liebscher, Sandra ; Schmidt, Stephanie ; Komeda, Hidenobu ; Asano, Yasuhisa ; Bordusa, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4710-e06362e85d2f2872ca3916045e17dc2e032a31285f4b0d7b768f5976542396653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acids</topic><topic>Biomimetic Materials</topic><topic>Escherichia coli Proteins - chemical synthesis</topic><topic>Methods</topic><topic>Peptide Hydrolases - metabolism</topic><topic>peptide ligation</topic><topic>Peptides - chemical synthesis</topic><topic>Peptidylprolyl Isomerase - chemical synthesis</topic><topic>proteases</topic><topic>protein semisynthesis</topic><topic>Proteins - chemical synthesis</topic><topic>substrate mimetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wehofsky, Nicole</creatorcontrib><creatorcontrib>Pech, Andreas</creatorcontrib><creatorcontrib>Liebscher, Sandra</creatorcontrib><creatorcontrib>Schmidt, Stephanie</creatorcontrib><creatorcontrib>Komeda, Hidenobu</creatorcontrib><creatorcontrib>Asano, Yasuhisa</creatorcontrib><creatorcontrib>Bordusa, Frank</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wehofsky, Nicole</au><au>Pech, Andreas</au><au>Liebscher, Sandra</au><au>Schmidt, Stephanie</au><au>Komeda, Hidenobu</au><au>Asano, Yasuhisa</au><au>Bordusa, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angewandte Chemie International Edition</addtitle><date>2008-07-07</date><risdate>2008</risdate><volume>47</volume><issue>29</issue><spage>5456</spage><epage>5460</epage><pages>5456-5460</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Side reactions side‐stepped: A D‐amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L‐amino acid specific enzymes are avoided in this approach.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>18551688</pmid><doi>10.1002/anie.200800340</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2008-07, Vol.47 (29), p.5456-5460 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69316346 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Amino Acids Biomimetic Materials Escherichia coli Proteins - chemical synthesis Methods Peptide Hydrolases - metabolism peptide ligation Peptides - chemical synthesis Peptidylprolyl Isomerase - chemical synthesis proteases protein semisynthesis Proteins - chemical synthesis substrate mimetics |
| title | D-Amino Acid Specific Proteases and Native All-L-Proteins: A Convenient Combination for Semisynthesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T16%3A24%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=D-Amino%20Acid%20Specific%20Proteases%20and%20Native%20All-L-Proteins:%20A%20Convenient%20Combination%20for%20Semisynthesis&rft.jtitle=Angewandte%20Chemie%20(International%20ed.)&rft.au=Wehofsky,%20Nicole&rft.date=2008-07-07&rft.volume=47&rft.issue=29&rft.spage=5456&rft.epage=5460&rft.pages=5456-5460&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.200800340&rft_dat=%3Cproquest_cross%3E69316346%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69316346&rft_id=info:pmid/18551688&rfr_iscdi=true |