Echinococcus granulosus: Induction of T-independent antibody response against protoscolex glycoconjugates in early experimental infection

In this work CD4-knockout mice were used as a model to analyse the role of CD4 + T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens...

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Veröffentlicht in:	Experimental parasitology 2008-08, Vol.119 (4), p.460-466
Hauptverfasser:	Baz, Adriana, Carol, Hernán, Fernández, Verónica, Mourglia-Ettlin, Gustavo, Nieto, Alberto, Örn, Anders, Dematteis, Sylvia
Format:	Artikel
Sprache:	eng
Schlagworte:	animal diseases Animals Antibodies, Helminth - biosynthesis Antibodies, Helminth - blood antibody formation antigen-antibody reactions antigens Antigens, Helminth - immunology carbohydrates CD4 + T cells CD4 Antigens - genetics CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology Cystic echinococcosis disease models disease resistance echinococcosis Echinococcosis - immunology Echinococcus granulosus Echinococcus granulosus - immunology Enzyme-Linked Immunosorbent Assay Epitopes - immunology Female glycoconjugates Glycoconjugates - immunology host-parasite relationships humoral immunity immunization Immunization - methods Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - classification infection knockout mutants Mice Mice, Inbred C57BL Mice, Knockout pathogenesis physiological response protoscoleces T-independent antigens T-lymphocytes
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