The Spectrum of B-Cell Non-Hodgkin Lymphomas With Dual IgH-BCL2 and BCL6 Translocations
Dual IgH/BCL2 and BCL6 translocations are rarely observed in B-cell non-Hodgkin lymphomas (B-NHLs). We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations. Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diff...
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| Veröffentlicht in: | American journal of clinical pathology 2008-08, Vol.130 (2), p.193-201 |
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| creator | KELLER, Christian E NANDULA, Subhadra FISHER, Julie SUBRAMANIYAM, Shivakumar VAKIANI, Efsevia SAVAGE, David G MURTY, Vundavalli V ALOBEID, Bachir BHAGAT, Govind |
| description | Dual IgH/BCL2 and BCL6 translocations are rarely observed in B-cell non-Hodgkin lymphomas (B-NHLs). We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations. Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs), representing 6.1% of 132 B-NHLs in our series, including 6 (11%) of 56 FLs (grades 1, 2, and 3a) and 2 (3%) of 76 DLBCLs; 33% of FLs with dual translocations had variant morphologic features. All dual-translocation FLs were CD10+/BCL6+/BCL2+/MUM1-, and the DLBCLs demonstrated "activated" germinal center (CD10+/BCL6+/MUM1+) and non-germinal center (CD10-/BCL6+/MUM1+) phenotypes. BCL6 translocations in all cases involved nonimmunoglobulin genes/loci. Mean chromosome abnormalities in dual-translocation FLs and DLBCLs did not differ from IgH/BCL2 FLs and DLBCLs. Detection of dual translocations predominantly in low-grade FLs suggests that BCL6 abnormalities are acquired early in the histologic evolution of a subset of IgH/BCL2-associated FLs. |
| doi_str_mv | 10.1309/ELPKF130Q0MCMWU8 |
| format | Article |
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We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations. Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs), representing 6.1% of 132 B-NHLs in our series, including 6 (11%) of 56 FLs (grades 1, 2, and 3a) and 2 (3%) of 76 DLBCLs; 33% of FLs with dual translocations had variant morphologic features. All dual-translocation FLs were CD10+/BCL6+/BCL2+/MUM1-, and the DLBCLs demonstrated "activated" germinal center (CD10+/BCL6+/MUM1+) and non-germinal center (CD10-/BCL6+/MUM1+) phenotypes. BCL6 translocations in all cases involved nonimmunoglobulin genes/loci. Mean chromosome abnormalities in dual-translocation FLs and DLBCLs did not differ from IgH/BCL2 FLs and DLBCLs. Detection of dual translocations predominantly in low-grade FLs suggests that BCL6 abnormalities are acquired early in the histologic evolution of a subset of IgH/BCL2-associated FLs.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/ELPKF130Q0MCMWU8</identifier><identifier>PMID: 18628087</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 3 ; Female ; Genes, bcl-2 ; Genes, Immunoglobulin ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulin Heavy Chains - genetics ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell - genetics ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Proto-Oncogene Proteins c-bcl-6 - genetics ; Translocation, Genetic</subject><ispartof>American journal of clinical pathology, 2008-08, Vol.130 (2), p.193-201</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-582eb90359820fdd189945790b9771b6b6c054e34a7d64b84436ff9f5efbe77d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20525014$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18628087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KELLER, Christian E</creatorcontrib><creatorcontrib>NANDULA, Subhadra</creatorcontrib><creatorcontrib>FISHER, Julie</creatorcontrib><creatorcontrib>SUBRAMANIYAM, Shivakumar</creatorcontrib><creatorcontrib>VAKIANI, Efsevia</creatorcontrib><creatorcontrib>SAVAGE, David G</creatorcontrib><creatorcontrib>MURTY, Vundavalli V</creatorcontrib><creatorcontrib>ALOBEID, Bachir</creatorcontrib><creatorcontrib>BHAGAT, Govind</creatorcontrib><title>The Spectrum of B-Cell Non-Hodgkin Lymphomas With Dual IgH-BCL2 and BCL6 Translocations</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Dual IgH/BCL2 and BCL6 translocations are rarely observed in B-cell non-Hodgkin lymphomas (B-NHLs). We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations. Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs), representing 6.1% of 132 B-NHLs in our series, including 6 (11%) of 56 FLs (grades 1, 2, and 3a) and 2 (3%) of 76 DLBCLs; 33% of FLs with dual translocations had variant morphologic features. All dual-translocation FLs were CD10+/BCL6+/BCL2+/MUM1-, and the DLBCLs demonstrated "activated" germinal center (CD10+/BCL6+/MUM1+) and non-germinal center (CD10-/BCL6+/MUM1+) phenotypes. BCL6 translocations in all cases involved nonimmunoglobulin genes/loci. Mean chromosome abnormalities in dual-translocation FLs and DLBCLs did not differ from IgH/BCL2 FLs and DLBCLs. Detection of dual translocations predominantly in low-grade FLs suggests that BCL6 abnormalities are acquired early in the histologic evolution of a subset of IgH/BCL2-associated FLs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chromosomes, Human, Pair 14</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Female</subject><subject>Genes, bcl-2</subject><subject>Genes, Immunoglobulin</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Proto-Oncogene Proteins c-bcl-6 - genetics</subject><subject>Translocation, Genetic</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLlOxDAURS0EgmHpqZAb6ALPW2yXEJZBhE0MmjJyEpsJJPEQJwV_TxAjkGio3i3OvdI7CO0TOCYM9MlF-nBzOaZHuE1u589qDU2I5iySktJ1NAEAGmki2RbaDuEVgFAFfBNtERWPSckJms8WFj8tbdF3Q4O9w2dRYusa3_k2mvry5a1qcfrRLBe-MQHPq36BzwdT4-uXaXSWpBSbtsRjiPGsM22ofWH6yrdhF204Uwe7t7o76PnyYpZMo_T-6jo5TaOCCdVHQlGba2BCKwquLInSmgupIddSkjzO4wIEt4wbWcY8V5yz2DnthHW5lbJkO-joe3fZ-ffBhj5rqlCMH5jW-iFksWZEEMr-BSnEoKmWIwjfYNH5EDrrsmVXNab7yAhkX9azv9bHysFqe8gbW_4WVppH4HAFmFCY2o2qiir8cBQEFUA4-wSibogN</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>KELLER, Christian E</creator><creator>NANDULA, Subhadra</creator><creator>FISHER, Julie</creator><creator>SUBRAMANIYAM, Shivakumar</creator><creator>VAKIANI, Efsevia</creator><creator>SAVAGE, David G</creator><creator>MURTY, Vundavalli V</creator><creator>ALOBEID, Bachir</creator><creator>BHAGAT, Govind</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>The Spectrum of B-Cell Non-Hodgkin Lymphomas With Dual IgH-BCL2 and BCL6 Translocations</title><author>KELLER, Christian E ; NANDULA, Subhadra ; FISHER, Julie ; SUBRAMANIYAM, Shivakumar ; VAKIANI, Efsevia ; SAVAGE, David G ; MURTY, Vundavalli V ; ALOBEID, Bachir ; BHAGAT, Govind</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-582eb90359820fdd189945790b9771b6b6c054e34a7d64b84436ff9f5efbe77d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chromosomes, Human, Pair 14</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Female</topic><topic>Genes, bcl-2</topic><topic>Genes, Immunoglobulin</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Proto-Oncogene Proteins c-bcl-6 - genetics</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KELLER, Christian E</creatorcontrib><creatorcontrib>NANDULA, Subhadra</creatorcontrib><creatorcontrib>FISHER, Julie</creatorcontrib><creatorcontrib>SUBRAMANIYAM, Shivakumar</creatorcontrib><creatorcontrib>VAKIANI, Efsevia</creatorcontrib><creatorcontrib>SAVAGE, David G</creatorcontrib><creatorcontrib>MURTY, Vundavalli V</creatorcontrib><creatorcontrib>ALOBEID, Bachir</creatorcontrib><creatorcontrib>BHAGAT, Govind</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KELLER, Christian E</au><au>NANDULA, Subhadra</au><au>FISHER, Julie</au><au>SUBRAMANIYAM, Shivakumar</au><au>VAKIANI, Efsevia</au><au>SAVAGE, David G</au><au>MURTY, Vundavalli V</au><au>ALOBEID, Bachir</au><au>BHAGAT, Govind</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Spectrum of B-Cell Non-Hodgkin Lymphomas With Dual IgH-BCL2 and BCL6 Translocations</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>130</volume><issue>2</issue><spage>193</spage><epage>201</epage><pages>193-201</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Dual IgH/BCL2 and BCL6 translocations are rarely observed in B-cell non-Hodgkin lymphomas (B-NHLs). We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations. Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs), representing 6.1% of 132 B-NHLs in our series, including 6 (11%) of 56 FLs (grades 1, 2, and 3a) and 2 (3%) of 76 DLBCLs; 33% of FLs with dual translocations had variant morphologic features. All dual-translocation FLs were CD10+/BCL6+/BCL2+/MUM1-, and the DLBCLs demonstrated "activated" germinal center (CD10+/BCL6+/MUM1+) and non-germinal center (CD10-/BCL6+/MUM1+) phenotypes. BCL6 translocations in all cases involved nonimmunoglobulin genes/loci. Mean chromosome abnormalities in dual-translocation FLs and DLBCLs did not differ from IgH/BCL2 FLs and DLBCLs. Detection of dual translocations predominantly in low-grade FLs suggests that BCL6 abnormalities are acquired early in the histologic evolution of a subset of IgH/BCL2-associated FLs.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>18628087</pmid><doi>10.1309/ELPKF130Q0MCMWU8</doi><tpages>9</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 3 Female Genes, bcl-2 Genes, Immunoglobulin Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - genetics Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-bcl-6 - genetics Translocation, Genetic |
| title | The Spectrum of B-Cell Non-Hodgkin Lymphomas With Dual IgH-BCL2 and BCL6 Translocations |
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