Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

Purpose: Invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. Altered gene expression in these nontransformed stromal cells provides potential targets for therapy. The present st...

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Veröffentlicht in:	Clinical cancer research 2008-07, Vol.14 (14), p.4584-4592
Hauptverfasser:	Ostermann, Elinborg, Garin-Chesa, Pilar, Heider, Karl Heinz, Kalat, Milena, Lamche, Herbert, Puri, Christina, Kerjaschki, Dontscho, Rettig, Wolfgang J., Adolf, Guenther R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Specificity Antigens, Neoplasm - immunology Biomarkers, Tumor - immunology fibroblast activation protein Fibroblasts - immunology Gelatinases Humans Immunoconjugates - chemistry Immunoconjugates - immunology Immunoconjugates - therapeutic use Immunohistochemistry Immunotherapy - methods Macaca fascicularis Maytansine - chemistry Maytansine - immunology Maytansine - therapeutic use maytansinoid antibody-conjugate Membrane Proteins Mice Neoplasms - immunology Neoplasms - therapy Serine Endopeptidases - immunology Surface Plasmon Resonance targeted tumor therapy tumor stroma
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