Hypoxia-Inducible Factor-1 Is Central to Cardioprotection : A New Paradigm for Ischemic Preconditioning

Ischemic preconditioning provides strong cardioprotection from ischemia, but its molecular mechanisms remain unknown. Convincing evidence confirms a central role of hypoxia-inducible factor (HIF)-1 in mammalian oxygen homeostasis. Thus, we pursued HIF-1 as a central component of cardioprotection by...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2008-07, Vol.118 (2), p.166-175
Hauptverfasser:	ECKLE, Tobias, KÖHLER, David, LEHMANN, Rainer, EL KASMI, Karim C, ELTZSCHIG, Holger K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Dicarboxylic - pharmacology Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Hypoxia-Inducible Factor 1, alpha Subunit - agonists Hypoxia-Inducible Factor 1, alpha Subunit - physiology Ischemic Preconditioning Medical sciences Mice Mice, Knockout Myocardial Infarction - drug therapy Procollagen-Proline Dioxygenase - drug effects Receptor, Adenosine A2B - deficiency Receptor, Adenosine A2B - physiology RNA, Small Interfering - pharmacology Signal Transduction
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