Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer
Background: In light of the recently found contribution of angiogenic and inflammation-related factors to malignancies, this study investigated the possible association of the angiotensinogen gene (AGT) with increased risk of oral cancer. Materials and Methods: The M235T polymorphism, which influenc...
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| Veröffentlicht in: | Anticancer research 2008-05, Vol.28 (3A), p.1675-1679 |
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| creator | VAIRAKTARIS, Eleftherios YAPIJAKIS, Christos NEUKAM, Friedrich PATSOURIS, Efstratios VYLLIOTIS, Antonis DERKA, Spyridoula VASSILIOU, Stavros NKENKE, Emeka SEREFOGLOU, Zoe RAGOS, Vasileios CRITSELIS, Elena AVGOUSTIDIS, Dimitrios |
| description | Background: In light of the recently found contribution of angiogenic and inflammation-related factors to malignancies, this
study investigated the possible association of the angiotensinogen gene (AGT) with increased risk of oral cancer. Materials
and Methods: The M235T polymorphism, which influences AGT gene expression, was evaluated by restriction fragment length polymorphism
analysis in the DNA samples of 163 German and Greek patients with oral squamous cell carcinoma (OSCC) and 124 healthy controls
of equivalent gender, ethnicity and age. Results: No significant difference of the mutant (235T) allele, which results in
higher AGT gene expression, was observed in the whole patient group in comparison with the normal controls. Similarly, compared
to the controls no significant difference of either allele or carrier frequency was detected in almost every subgroup of patients.
Only in the subgroup of patients with a positive family history of cancer was a significant increase of mutant T allele and
carrier frequencies observed, compared to the controls (50% vs. 36.7% and 79.3% vs. 61.3%, respectively, p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69313501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69313501</sourcerecordid><originalsourceid>FETCH-LOGICAL-h270t-859e3fd943e4cf6c05cca009578f7924b502c929acaa108bcad017ec567b79d63</originalsourceid><addsrcrecordid>eNpFkU9LxDAQxYso7rr6FSQXvRUmTZM0x2XxH6ysiJ48lDRN22iarEnLst_eoqteZuDx4z3mzVEyx1zglFMCx8kcMgopB6Cz5CzGdwDGREFOkxkuGAGa0XnytnSt8YN20TjfaoeevN33Pmw7E3tkIlrG6JWRg67RzgwdejbxAzU-oEdpTeukU3tUjQNyfviWN0FatJpkHc6Tk0baqC8Oe5G83t68rO7T9ebuYbVcp13GYUgLKjRpapETnauGKaBKSQBBedFwkeUVhUyJTEglJYaiUrIGzLWijFdc1Iwskusf323wn6OOQ9mbqLS10mk_xpIJggkFPIGXB3Csel2X22B6Gfblbx0TcHUAZFTSNmG6w8Q_LoM8p9P4T-xM2-1M0GXspbWTLSllyIqSLEvMpi98AXP4dxU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69313501</pqid></control><display><type>article</type><title>Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; NEUKAM, Friedrich ; PATSOURIS, Efstratios ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASSILIOU, Stavros ; NKENKE, Emeka ; SEREFOGLOU, Zoe ; RAGOS, Vasileios ; CRITSELIS, Elena ; AVGOUSTIDIS, Dimitrios</creator><creatorcontrib>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; NEUKAM, Friedrich ; PATSOURIS, Efstratios ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASSILIOU, Stavros ; NKENKE, Emeka ; SEREFOGLOU, Zoe ; RAGOS, Vasileios ; CRITSELIS, Elena ; AVGOUSTIDIS, Dimitrios</creatorcontrib><description>Background: In light of the recently found contribution of angiogenic and inflammation-related factors to malignancies, this
study investigated the possible association of the angiotensinogen gene (AGT) with increased risk of oral cancer. Materials
and Methods: The M235T polymorphism, which influences AGT gene expression, was evaluated by restriction fragment length polymorphism
analysis in the DNA samples of 163 German and Greek patients with oral squamous cell carcinoma (OSCC) and 124 healthy controls
of equivalent gender, ethnicity and age. Results: No significant difference of the mutant (235T) allele, which results in
higher AGT gene expression, was observed in the whole patient group in comparison with the normal controls. Similarly, compared
to the controls no significant difference of either allele or carrier frequency was detected in almost every subgroup of patients.
Only in the subgroup of patients with a positive family history of cancer was a significant increase of mutant T allele and
carrier frequencies observed, compared to the controls (50% vs. 36.7% and 79.3% vs. 61.3%, respectively, p<0.05 in both cases).
In this particular subgroup of patients the odds ratio for OSCC of TT homozygotes was 3.57 (CI 95% 1.2-10.62), while for the
MT heterozygotes it was 2.41 (CI 95% 1.06-5.49). Conclusion: This study did not reveal an association of the AGT M235T polymorphism
with oral oncogenesis, but certainly suggested a possible association of this specific polymorphism with other types of cancer.
The present findings support a previous suggestion that the pathway of oral oncogenesis is probably based on angiotensin-converting
enzyme and bradykinin interaction and not on AGT and angiotensin peptides.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 18630525</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Angiotensinogen - biosynthesis ; Angiotensinogen - genetics ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; DNA, Neoplasm - genetics ; Gene Expression ; Genetic Predisposition to Disease ; Humans ; Medical sciences ; Middle Aged ; Mouth Neoplasms - genetics ; Mouth Neoplasms - metabolism ; Otorhinolaryngology. Stomatology ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Anticancer research, 2008-05, Vol.28 (3A), p.1675-1679</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20445204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18630525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAIRAKTARIS, Eleftherios</creatorcontrib><creatorcontrib>YAPIJAKIS, Christos</creatorcontrib><creatorcontrib>NEUKAM, Friedrich</creatorcontrib><creatorcontrib>PATSOURIS, Efstratios</creatorcontrib><creatorcontrib>VYLLIOTIS, Antonis</creatorcontrib><creatorcontrib>DERKA, Spyridoula</creatorcontrib><creatorcontrib>VASSILIOU, Stavros</creatorcontrib><creatorcontrib>NKENKE, Emeka</creatorcontrib><creatorcontrib>SEREFOGLOU, Zoe</creatorcontrib><creatorcontrib>RAGOS, Vasileios</creatorcontrib><creatorcontrib>CRITSELIS, Elena</creatorcontrib><creatorcontrib>AVGOUSTIDIS, Dimitrios</creatorcontrib><title>Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: In light of the recently found contribution of angiogenic and inflammation-related factors to malignancies, this
study investigated the possible association of the angiotensinogen gene (AGT) with increased risk of oral cancer. Materials
and Methods: The M235T polymorphism, which influences AGT gene expression, was evaluated by restriction fragment length polymorphism
analysis in the DNA samples of 163 German and Greek patients with oral squamous cell carcinoma (OSCC) and 124 healthy controls
of equivalent gender, ethnicity and age. Results: No significant difference of the mutant (235T) allele, which results in
higher AGT gene expression, was observed in the whole patient group in comparison with the normal controls. Similarly, compared
to the controls no significant difference of either allele or carrier frequency was detected in almost every subgroup of patients.
Only in the subgroup of patients with a positive family history of cancer was a significant increase of mutant T allele and
carrier frequencies observed, compared to the controls (50% vs. 36.7% and 79.3% vs. 61.3%, respectively, p<0.05 in both cases).
In this particular subgroup of patients the odds ratio for OSCC of TT homozygotes was 3.57 (CI 95% 1.2-10.62), while for the
MT heterozygotes it was 2.41 (CI 95% 1.06-5.49). Conclusion: This study did not reveal an association of the AGT M235T polymorphism
with oral oncogenesis, but certainly suggested a possible association of this specific polymorphism with other types of cancer.
The present findings support a previous suggestion that the pathway of oral oncogenesis is probably based on angiotensin-converting
enzyme and bradykinin interaction and not on AGT and angiotensin peptides.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Angiotensinogen - biosynthesis</subject><subject>Angiotensinogen - genetics</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9LxDAQxYso7rr6FSQXvRUmTZM0x2XxH6ysiJ48lDRN22iarEnLst_eoqteZuDx4z3mzVEyx1zglFMCx8kcMgopB6Cz5CzGdwDGREFOkxkuGAGa0XnytnSt8YN20TjfaoeevN33Pmw7E3tkIlrG6JWRg67RzgwdejbxAzU-oEdpTeukU3tUjQNyfviWN0FatJpkHc6Tk0baqC8Oe5G83t68rO7T9ebuYbVcp13GYUgLKjRpapETnauGKaBKSQBBedFwkeUVhUyJTEglJYaiUrIGzLWijFdc1Iwskusf323wn6OOQ9mbqLS10mk_xpIJggkFPIGXB3Csel2X22B6Gfblbx0TcHUAZFTSNmG6w8Q_LoM8p9P4T-xM2-1M0GXspbWTLSllyIqSLEvMpi98AXP4dxU</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>VAIRAKTARIS, Eleftherios</creator><creator>YAPIJAKIS, Christos</creator><creator>NEUKAM, Friedrich</creator><creator>PATSOURIS, Efstratios</creator><creator>VYLLIOTIS, Antonis</creator><creator>DERKA, Spyridoula</creator><creator>VASSILIOU, Stavros</creator><creator>NKENKE, Emeka</creator><creator>SEREFOGLOU, Zoe</creator><creator>RAGOS, Vasileios</creator><creator>CRITSELIS, Elena</creator><creator>AVGOUSTIDIS, Dimitrios</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer</title><author>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; NEUKAM, Friedrich ; PATSOURIS, Efstratios ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASSILIOU, Stavros ; NKENKE, Emeka ; SEREFOGLOU, Zoe ; RAGOS, Vasileios ; CRITSELIS, Elena ; AVGOUSTIDIS, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-859e3fd943e4cf6c05cca009578f7924b502c929acaa108bcad017ec567b79d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Angiotensinogen - biosynthesis</topic><topic>Angiotensinogen - genetics</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Expression</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAIRAKTARIS, Eleftherios</creatorcontrib><creatorcontrib>YAPIJAKIS, Christos</creatorcontrib><creatorcontrib>NEUKAM, Friedrich</creatorcontrib><creatorcontrib>PATSOURIS, Efstratios</creatorcontrib><creatorcontrib>VYLLIOTIS, Antonis</creatorcontrib><creatorcontrib>DERKA, Spyridoula</creatorcontrib><creatorcontrib>VASSILIOU, Stavros</creatorcontrib><creatorcontrib>NKENKE, Emeka</creatorcontrib><creatorcontrib>SEREFOGLOU, Zoe</creatorcontrib><creatorcontrib>RAGOS, Vasileios</creatorcontrib><creatorcontrib>CRITSELIS, Elena</creatorcontrib><creatorcontrib>AVGOUSTIDIS, Dimitrios</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAIRAKTARIS, Eleftherios</au><au>YAPIJAKIS, Christos</au><au>NEUKAM, Friedrich</au><au>PATSOURIS, Efstratios</au><au>VYLLIOTIS, Antonis</au><au>DERKA, Spyridoula</au><au>VASSILIOU, Stavros</au><au>NKENKE, Emeka</au><au>SEREFOGLOU, Zoe</au><au>RAGOS, Vasileios</au><au>CRITSELIS, Elena</au><au>AVGOUSTIDIS, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>28</volume><issue>3A</issue><spage>1675</spage><epage>1679</epage><pages>1675-1679</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: In light of the recently found contribution of angiogenic and inflammation-related factors to malignancies, this
study investigated the possible association of the angiotensinogen gene (AGT) with increased risk of oral cancer. Materials
and Methods: The M235T polymorphism, which influences AGT gene expression, was evaluated by restriction fragment length polymorphism
analysis in the DNA samples of 163 German and Greek patients with oral squamous cell carcinoma (OSCC) and 124 healthy controls
of equivalent gender, ethnicity and age. Results: No significant difference of the mutant (235T) allele, which results in
higher AGT gene expression, was observed in the whole patient group in comparison with the normal controls. Similarly, compared
to the controls no significant difference of either allele or carrier frequency was detected in almost every subgroup of patients.
Only in the subgroup of patients with a positive family history of cancer was a significant increase of mutant T allele and
carrier frequencies observed, compared to the controls (50% vs. 36.7% and 79.3% vs. 61.3%, respectively, p<0.05 in both cases).
In this particular subgroup of patients the odds ratio for OSCC of TT homozygotes was 3.57 (CI 95% 1.2-10.62), while for the
MT heterozygotes it was 2.41 (CI 95% 1.06-5.49). Conclusion: This study did not reveal an association of the AGT M235T polymorphism
with oral oncogenesis, but certainly suggested a possible association of this specific polymorphism with other types of cancer.
The present findings support a previous suggestion that the pathway of oral oncogenesis is probably based on angiotensin-converting
enzyme and bradykinin interaction and not on AGT and angiotensin peptides.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>18630525</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Anticancer research, 2008-05, Vol.28 (3A), p.1675-1679 |
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| subjects | Adult Aged Aged, 80 and over Alleles Angiotensinogen - biosynthesis Angiotensinogen - genetics Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism DNA, Neoplasm - genetics Gene Expression Genetic Predisposition to Disease Humans Medical sciences Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Otorhinolaryngology. Stomatology Polymorphism, Genetic Polymorphism, Restriction Fragment Length Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Angiotensinogen Polymorphism is Associated with Risk for Malignancy but not for Oral Cancer |
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