Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal End Group and Varying Satellite Groups
The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. Three comparable PMOX with a DDA end group and different satell...
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| Veröffentlicht in: | Biomacromolecules 2008-07, Vol.9 (7), p.1764-1771 |
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| container_title | Biomacromolecules |
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| creator | Waschinski, Christian J Barnert, Sabine Theobald, Alice Schubert, Rolf Kleinschmidt, Felix Hoffmann, Anke Saalwächter, Kay Tiller, Joerg C |
| description | The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. Three comparable PMOX with a DDA end group and different satellite groups (methyl, decyl, hexadecyl) were investigated with respect to the reasons for the huge differences in their biocidal behavior. Static light scattering (SLS) and pulsed field gradient diffusion NMR measurements revealed that the samples show comparable aggregation conduct, thus, not being responsible for the varying biological activity. Experiments using different liposomal systems as models for bacterial cell membranes have been performed. It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations. |
| doi_str_mv | 10.1021/bm7013944 |
| format | Article |
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Three comparable PMOX with a DDA end group and different satellite groups (methyl, decyl, hexadecyl) were investigated with respect to the reasons for the huge differences in their biocidal behavior. Static light scattering (SLS) and pulsed field gradient diffusion NMR measurements revealed that the samples show comparable aggregation conduct, thus, not being responsible for the varying biological activity. Experiments using different liposomal systems as models for bacterial cell membranes have been performed. It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations.</description><identifier>ISSN: 1525-7797</identifier><identifier>EISSN: 1526-4602</identifier><identifier>DOI: 10.1021/bm7013944</identifier><identifier>PMID: 18572919</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Anti-Bacterial Agents - chemistry ; Applied sciences ; Bacteria - ultrastructure ; Cell Membrane - drug effects ; Exact sciences and technology ; Liposomes ; Magnetic Resonance Spectroscopy ; Models, Biological ; Organic polymers ; Oxazoles - chemistry ; Oxazoles - pharmacology ; Physicochemistry of polymers ; Polymers - chemistry ; Polymers - pharmacology ; Properties and characterization ; Special properties (catalyst, reagent or carrier) ; Structure-Activity Relationship</subject><ispartof>Biomacromolecules, 2008-07, Vol.9 (7), p.1764-1771</ispartof><rights>Copyright © 2008 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a289t-71af5192bfe6ab6db7686b200f5426a4c0e815ea9acf4b172dec5a9ff986dc953</citedby><cites>FETCH-LOGICAL-a289t-71af5192bfe6ab6db7686b200f5426a4c0e815ea9acf4b172dec5a9ff986dc953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/bm7013944$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/bm7013944$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20870159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18572919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Waschinski, Christian J</creatorcontrib><creatorcontrib>Barnert, Sabine</creatorcontrib><creatorcontrib>Theobald, Alice</creatorcontrib><creatorcontrib>Schubert, Rolf</creatorcontrib><creatorcontrib>Kleinschmidt, Felix</creatorcontrib><creatorcontrib>Hoffmann, Anke</creatorcontrib><creatorcontrib>Saalwächter, Kay</creatorcontrib><creatorcontrib>Tiller, Joerg C</creatorcontrib><title>Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal End Group and Varying Satellite Groups</title><title>Biomacromolecules</title><addtitle>Biomacromolecules</addtitle><description>The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. 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It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Applied sciences</subject><subject>Bacteria - ultrastructure</subject><subject>Cell Membrane - drug effects</subject><subject>Exact sciences and technology</subject><subject>Liposomes</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Models, Biological</subject><subject>Organic polymers</subject><subject>Oxazoles - chemistry</subject><subject>Oxazoles - pharmacology</subject><subject>Physicochemistry of polymers</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Properties and characterization</subject><subject>Special properties (catalyst, reagent or carrier)</subject><subject>Structure-Activity Relationship</subject><issn>1525-7797</issn><issn>1526-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qqHz10D-AfKGCQ4rtxE583CK-JCQqQXuNJo7NGiX2YjuC5ddj2BVwQOppRppn3pl5B6EflPyihNGjbqwJLWVVfUFblDNRVIKwr685L-pa1ptoO8Y7QogsK_4NbdKG10xSuYWmCxft7TxFbB1Oc41nLtkOVNLBwoBnKlnvsDf4jx-WB6NO8-XgH-HJD9bpw4gfbJpjwL-tV7bPDSeux2fBTwsMOfsHYWndLb6GpIfBJr2qxV20YWCI-vs67qC_pyc3x-fF5dXZxfHssgDWyFTUFAynknVGC-hE39WiER0jxPCKCagU0Q3lGiQoU3W0Zr1WHKQxshG9krzcQT9Xuovg7ycdUzvaqPIq4LSfYitkScuyYv8FqRR5IqMZPFyBKvgYgzbtItgxn9lS0r48o317Rmb31qJTN-r-nVy7n4H9NQBRwWACOGXjG8dIk6X4Bw5UbO_8FFw27ZOBz3AingA</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Waschinski, Christian J</creator><creator>Barnert, Sabine</creator><creator>Theobald, Alice</creator><creator>Schubert, Rolf</creator><creator>Kleinschmidt, Felix</creator><creator>Hoffmann, Anke</creator><creator>Saalwächter, Kay</creator><creator>Tiller, Joerg C</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal End Group and Varying Satellite Groups</title><author>Waschinski, Christian J ; Barnert, Sabine ; Theobald, Alice ; Schubert, Rolf ; Kleinschmidt, Felix ; Hoffmann, Anke ; Saalwächter, Kay ; Tiller, Joerg C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a289t-71af5192bfe6ab6db7686b200f5426a4c0e815ea9acf4b172dec5a9ff986dc953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Applied sciences</topic><topic>Bacteria - ultrastructure</topic><topic>Cell Membrane - drug effects</topic><topic>Exact sciences and technology</topic><topic>Liposomes</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Models, Biological</topic><topic>Organic polymers</topic><topic>Oxazoles - chemistry</topic><topic>Oxazoles - pharmacology</topic><topic>Physicochemistry of polymers</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>Properties and characterization</topic><topic>Special properties (catalyst, reagent or carrier)</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waschinski, Christian J</creatorcontrib><creatorcontrib>Barnert, Sabine</creatorcontrib><creatorcontrib>Theobald, Alice</creatorcontrib><creatorcontrib>Schubert, Rolf</creatorcontrib><creatorcontrib>Kleinschmidt, Felix</creatorcontrib><creatorcontrib>Hoffmann, Anke</creatorcontrib><creatorcontrib>Saalwächter, Kay</creatorcontrib><creatorcontrib>Tiller, Joerg C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomacromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waschinski, Christian J</au><au>Barnert, Sabine</au><au>Theobald, Alice</au><au>Schubert, Rolf</au><au>Kleinschmidt, Felix</au><au>Hoffmann, Anke</au><au>Saalwächter, Kay</au><au>Tiller, Joerg C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal End Group and Varying Satellite Groups</atitle><jtitle>Biomacromolecules</jtitle><addtitle>Biomacromolecules</addtitle><date>2008-07</date><risdate>2008</risdate><volume>9</volume><issue>7</issue><spage>1764</spage><epage>1771</epage><pages>1764-1771</pages><issn>1525-7797</issn><eissn>1526-4602</eissn><abstract>The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent on the nature of the group at the distal end of the polymer, the satellite group. Three comparable PMOX with a DDA end group and different satellite groups (methyl, decyl, hexadecyl) were investigated with respect to the reasons for the huge differences in their biocidal behavior. Static light scattering (SLS) and pulsed field gradient diffusion NMR measurements revealed that the samples show comparable aggregation conduct, thus, not being responsible for the varying biological activity. Experiments using different liposomal systems as models for bacterial cell membranes have been performed. It was found that differential interactions between the respective polymers and the phospholipid membranes constitute the reason for the varying effectiveness observed in antimicrobial susceptibility determinations.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18572919</pmid><doi>10.1021/bm7013944</doi><tpages>8</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Applied sciences Bacteria - ultrastructure Cell Membrane - drug effects Exact sciences and technology Liposomes Magnetic Resonance Spectroscopy Models, Biological Organic polymers Oxazoles - chemistry Oxazoles - pharmacology Physicochemistry of polymers Polymers - chemistry Polymers - pharmacology Properties and characterization Special properties (catalyst, reagent or carrier) Structure-Activity Relationship |
| title | Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal End Group and Varying Satellite Groups |
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