Brain Metastases in Relapsed Epithelial Ovarian Cancer after Chemotherapy with Pegylated Liposomal Doxorubicin
Background: Brain metastases in epithelial ovarian cancer (EOC) occur rarely and are associated with a poor prognosis. No significant risk factors have been identified and no evidence-based treatment guidelines are currently available. Case Report: A 56-year-old EOC patient presented with seizure at...
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| Veröffentlicht in: | Anticancer research 2008-05, Vol.28 (3B), p.1943-1946 |
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| container_issue | 3B |
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| container_title | Anticancer research |
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| creator | Kasprowicz, Nikola Serena Fotopoulou, Christina Oskay-Ozcelik, Gülten El, Khalfaoui Khalid Boehmer, Dirk Sehouli, Jalid |
| description | Background: Brain metastases in epithelial ovarian cancer (EOC) occur rarely and are associated with a poor prognosis. No
significant risk factors have been identified and no evidence-based treatment guidelines are currently available. Case Report:
A 56-year-old EOC patient presented with seizure at the Emergency Department eleven days after completion of fourth-line chemotherapy
with pegylated liposomal doxorubicin (PLD). A computed tomography (CT) scan revealed multiple metastases. The patient received
radiotherapy with a total dose of 30.8 Gy and 8 cycles of paclitaxel resulting in stable disease. Based on the current literature,
treatment options are discussed. Conclusion: Therapeutic options for brain metastases include radiation, systemic or intrathecal
chemotherapy, surgery or a combination regime. Since the effectiveness of systemic chemotherapy remains controversial, current
research focuses on developing new anticancer drugs that penetrate the blood-brain barrier in order to prevent and/or treat
brain metastases. |
| format | Article |
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significant risk factors have been identified and no evidence-based treatment guidelines are currently available. Case Report:
A 56-year-old EOC patient presented with seizure at the Emergency Department eleven days after completion of fourth-line chemotherapy
with pegylated liposomal doxorubicin (PLD). A computed tomography (CT) scan revealed multiple metastases. The patient received
radiotherapy with a total dose of 30.8 Gy and 8 cycles of paclitaxel resulting in stable disease. Based on the current literature,
treatment options are discussed. Conclusion: Therapeutic options for brain metastases include radiation, systemic or intrathecal
chemotherapy, surgery or a combination regime. Since the effectiveness of systemic chemotherapy remains controversial, current
research focuses on developing new anticancer drugs that penetrate the blood-brain barrier in order to prevent and/or treat
brain metastases.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 18630485</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Antibiotics, Antineoplastic - therapeutic use ; Biological and medical sciences ; Brain Neoplasms - secondary ; Doxorubicin - analogs & derivatives ; Doxorubicin - therapeutic use ; Female ; Humans ; Medical sciences ; Middle Aged ; Neurology ; Ovarian Neoplasms - drug therapy ; Ovarian Neoplasms - pathology ; Polyethylene Glycols - therapeutic use ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Anticancer research, 2008-05, Vol.28 (3B), p.1943-1946</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20444702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18630485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasprowicz, Nikola Serena</creatorcontrib><creatorcontrib>Fotopoulou, Christina</creatorcontrib><creatorcontrib>Oskay-Ozcelik, Gülten</creatorcontrib><creatorcontrib>El, Khalfaoui Khalid</creatorcontrib><creatorcontrib>Boehmer, Dirk</creatorcontrib><creatorcontrib>Sehouli, Jalid</creatorcontrib><title>Brain Metastases in Relapsed Epithelial Ovarian Cancer after Chemotherapy with Pegylated Liposomal Doxorubicin</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Brain metastases in epithelial ovarian cancer (EOC) occur rarely and are associated with a poor prognosis. No
significant risk factors have been identified and no evidence-based treatment guidelines are currently available. Case Report:
A 56-year-old EOC patient presented with seizure at the Emergency Department eleven days after completion of fourth-line chemotherapy
with pegylated liposomal doxorubicin (PLD). A computed tomography (CT) scan revealed multiple metastases. The patient received
radiotherapy with a total dose of 30.8 Gy and 8 cycles of paclitaxel resulting in stable disease. Based on the current literature,
treatment options are discussed. Conclusion: Therapeutic options for brain metastases include radiation, systemic or intrathecal
chemotherapy, surgery or a combination regime. Since the effectiveness of systemic chemotherapy remains controversial, current
research focuses on developing new anticancer drugs that penetrate the blood-brain barrier in order to prevent and/or treat
brain metastases.</description><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - secondary</subject><subject>Doxorubicin - analogs & derivatives</subject><subject>Doxorubicin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Polyethylene Glycols - therapeutic use</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1r3DAQBmBTGrqbtH8h-JLeDCONZdnH7DZfsGVDSM5mZMmxgvwRydvN_vsIsmmPhUGD4JkZeL8kSyYrlkmB8DVZAheQSQCxSE5DeAEoiqrEb8mClQVCXoplMqw82SH9bWYKsUxI4-_BOJqC0enVZOfOOEsu3f4hb2lI1zQ0xqfUzvFdd6Yfo_A0HdJ9tOm9eT44muPsxk5jGPs4-mt8G_1O2cYO35OTllwwP479LHm6vnpc32ab7c3d-nKTdQhszhqVM9CKKp4DFhIFQyl0riQp0G1puG4UadEKoYlrVIoKbLTShJJxXbV4lvz82Dv58XVnwlz3NjTGORrMuAt1USFDDvK_kEPJUUAV4fkR7lRvdD1525M_1J9RRnBxBBQacq2PQdnw13HI81wC_3exs8_d3npThxiSi2uxJs_LGlc1q3LEd4NHjLQ</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Kasprowicz, Nikola Serena</creator><creator>Fotopoulou, Christina</creator><creator>Oskay-Ozcelik, Gülten</creator><creator>El, Khalfaoui Khalid</creator><creator>Boehmer, Dirk</creator><creator>Sehouli, Jalid</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Brain Metastases in Relapsed Epithelial Ovarian Cancer after Chemotherapy with Pegylated Liposomal Doxorubicin</title><author>Kasprowicz, Nikola Serena ; Fotopoulou, Christina ; Oskay-Ozcelik, Gülten ; El, Khalfaoui Khalid ; Boehmer, Dirk ; Sehouli, Jalid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-cb410dba9240367351375d4b7ab0df8e2dcbad5f55da2d3bba63cdbda3712d9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - secondary</topic><topic>Doxorubicin - analogs & derivatives</topic><topic>Doxorubicin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Polyethylene Glycols - therapeutic use</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasprowicz, Nikola Serena</creatorcontrib><creatorcontrib>Fotopoulou, Christina</creatorcontrib><creatorcontrib>Oskay-Ozcelik, Gülten</creatorcontrib><creatorcontrib>El, Khalfaoui Khalid</creatorcontrib><creatorcontrib>Boehmer, Dirk</creatorcontrib><creatorcontrib>Sehouli, Jalid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasprowicz, Nikola Serena</au><au>Fotopoulou, Christina</au><au>Oskay-Ozcelik, Gülten</au><au>El, Khalfaoui Khalid</au><au>Boehmer, Dirk</au><au>Sehouli, Jalid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Metastases in Relapsed Epithelial Ovarian Cancer after Chemotherapy with Pegylated Liposomal Doxorubicin</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>28</volume><issue>3B</issue><spage>1943</spage><epage>1946</epage><pages>1943-1946</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Brain metastases in epithelial ovarian cancer (EOC) occur rarely and are associated with a poor prognosis. No
significant risk factors have been identified and no evidence-based treatment guidelines are currently available. Case Report:
A 56-year-old EOC patient presented with seizure at the Emergency Department eleven days after completion of fourth-line chemotherapy
with pegylated liposomal doxorubicin (PLD). A computed tomography (CT) scan revealed multiple metastases. The patient received
radiotherapy with a total dose of 30.8 Gy and 8 cycles of paclitaxel resulting in stable disease. Based on the current literature,
treatment options are discussed. Conclusion: Therapeutic options for brain metastases include radiation, systemic or intrathecal
chemotherapy, surgery or a combination regime. Since the effectiveness of systemic chemotherapy remains controversial, current
research focuses on developing new anticancer drugs that penetrate the blood-brain barrier in order to prevent and/or treat
brain metastases.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>18630485</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences Brain Neoplasms - secondary Doxorubicin - analogs & derivatives Doxorubicin - therapeutic use Female Humans Medical sciences Middle Aged Neurology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Polyethylene Glycols - therapeutic use Tumors Tumors of the nervous system. Phacomatoses |
| title | Brain Metastases in Relapsed Epithelial Ovarian Cancer after Chemotherapy with Pegylated Liposomal Doxorubicin |
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