Down-regulation of miR-1/miR-133 Contributes to Re-expression of Pacemaker Channel Genes HCN2 and HCN4 in Hypertrophic Heart

Cardiac hypertrophy is characterized by electrical remolding with increased risk of arrhythmogenesis. Enhanced abnormal automaticity of ventricular cells contributes critically to hypertrophic arrhythmias. The pacemaker current If, carried by the hyperpolarization-activated channels encoded mainly b...

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Veröffentlicht in:	The Journal of biological chemistry 2008-07, Vol.283 (29), p.20045-20052
Hauptverfasser:	Luo, Xiaobin, Lin, Huixian, Pan, Zhengwei, Xiao, Jiening, Zhang, Yong, Lu, Yanjie, Yang, Baofeng, Wang, Zhiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Base Sequence Cardiomegaly - genetics Cells, Cultured Cyclic Nucleotide-Gated Cation Channels - genetics Down-Regulation Heart Ventricles - metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Ion Channels - genetics Male MicroRNAs - genetics Muscle Proteins - genetics Potassium Channels - genetics Rats Rats, Sprague-Dawley
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