Diastereoselective Friedel−Crafts Alkylation of Indoles with Chiral α-Phenyl Benzylic Cations. Asymmetric Synthesis of Anti-1,1,2-Triarylalkanes

The reactions of chiral benzyl carbocations bearing α-phenyl substituents with N-sulfonylated indoles afford 1,1,2-triarylalkanes with anti-selectivities. This outcome is a reversal of facial diastereoselectivity relative to Bach’s α-alkyl-bearing benzyl cations. The reactions are promoted by either...

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Veröffentlicht in:	Organic letters 2008-07, Vol.10 (14), p.3037-3040
Hauptverfasser:	Chung, John Y. L, Mancheno, Danny, Dormer, Peter G, Variankaval, Narayan, Ball, Richard G, Tsou, Nancy N
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemical synthesis Alkanes - chemistry Alkylation Benzene Derivatives - chemistry Catalysis Combinatorial Chemistry Techniques Indoles - chemistry Molecular Structure Stereoisomerism
Online-Zugang:	Volltext
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