Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities – report of four cases and review of the literature
Serositis is a common clinical manifestation of systemic lupus erythematosus (SLE), as well as being the hallmark of familial Mediterranean fever (FMF), the most prevalent monogenic disease in the Jewish population. We have treated four patients who suffered from both SLE and FMF since 2001 in our c...
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Veröffentlicht in: | Lupus 2008-07, Vol.17 (7), p.663-669 |
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description | Serositis is a common clinical manifestation of systemic lupus erythematosus (SLE), as well as being the hallmark of familial Mediterranean fever (FMF), the most prevalent monogenic disease in the Jewish population. We have treated four patients who suffered from both SLE and FMF since 2001 in our clinic, which also serves as the national center for FMF. Our cases illustrate both similarities and dissimilarities between the clinical manifestations of these two diseases, an aspect which should be borne in mind, especially in the young female patients. In general, it seems that co-occurrence of FMF moderates the presentation of lupus. |
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We have treated four patients who suffered from both SLE and FMF since 2001 in our clinic, which also serves as the national center for FMF. Our cases illustrate both similarities and dissimilarities between the clinical manifestations of these two diseases, an aspect which should be borne in mind, especially in the young female patients. 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In general, it seems that co-occurrence of FMF moderates the presentation of lupus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Familial Mediterranean Fever - genetics</subject><subject>Familial Mediterranean Fever - pathology</subject><subject>Familial Mediterranean Fever - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Jews - genetics</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Review Literature as Topic</subject><subject>Serositis - physiopathology</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1u1DAQxy0EotvCnRMaceAWGH_kixuqoCAV9dByjpx4UlwlcbCdXe2Nd-BZeCGepI52pUqVEL7Y4_nNfzTzZ-wVx3ecl-V7rAsuUEqssKoVyidsw1VZZulfPGWbNZ2t-RN2GsIdIkpeF8_ZCa8KkRey3rA_1_sQabQdDMu8BCC_jz9o1NGFFOnJQK9HO1g9wDcyNpL3eiI9QU9b8h9Aw-xCsO1AMNGtjnZLoENwnU1vN0FLcUc0QRKFuHNgbCAdCGiKNloK8PfXb_A0Ox_B9dC7xUOXgENvT1tLuzWx1g9rex0XTy_Ys14PgV4e7zP2_fOnm_Mv2eXVxdfzj5dZp_I6ZqZVRSkrJJQtKSX6rpLrqY3uSmNIKDSmrlBzzLlqBee5LNGQ7ChvBVbyjL096M7e_VwoxGa0oaNhSDtwS2iKWvK0y_q_oMBkjyjLBL55BN6lkac0RCOEKJTi-QrhAep8Wq6nvpm9HbXfNxyb1fjmsfGp5PVRd2lHMg8FR6cTkB2AoG_poek_Be8BJda5Uw</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Lidar, M</creator><creator>Zandman-Goddard, G</creator><creator>Shinar, Y</creator><creator>Zaks, N</creator><creator>Livneh, A</creator><creator>Langevitz, P</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities – report of four cases and review of the literature</title><author>Lidar, M ; 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subjects | Adolescent Adult Child Familial Mediterranean Fever - genetics Familial Mediterranean Fever - pathology Familial Mediterranean Fever - physiopathology Female Humans Jews - genetics Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - pathology Lupus Erythematosus, Systemic - physiopathology Middle Aged Pregnancy Review Literature as Topic Serositis - physiopathology |
title | Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities – report of four cases and review of the literature |
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