Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities – report of four cases and review of the literature

Serositis is a common clinical manifestation of systemic lupus erythematosus (SLE), as well as being the hallmark of familial Mediterranean fever (FMF), the most prevalent monogenic disease in the Jewish population. We have treated four patients who suffered from both SLE and FMF since 2001 in our c...

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Veröffentlicht in:Lupus 2008-07, Vol.17 (7), p.663-669
Hauptverfasser: Lidar, M, Zandman-Goddard, G, Shinar, Y, Zaks, N, Livneh, A, Langevitz, P
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container_end_page 669
container_issue 7
container_start_page 663
container_title Lupus
container_volume 17
creator Lidar, M
Zandman-Goddard, G
Shinar, Y
Zaks, N
Livneh, A
Langevitz, P
description Serositis is a common clinical manifestation of systemic lupus erythematosus (SLE), as well as being the hallmark of familial Mediterranean fever (FMF), the most prevalent monogenic disease in the Jewish population. We have treated four patients who suffered from both SLE and FMF since 2001 in our clinic, which also serves as the national center for FMF. Our cases illustrate both similarities and dissimilarities between the clinical manifestations of these two diseases, an aspect which should be borne in mind, especially in the young female patients. In general, it seems that co-occurrence of FMF moderates the presentation of lupus.
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subjects Adolescent
Adult
Child
Familial Mediterranean Fever - genetics
Familial Mediterranean Fever - pathology
Familial Mediterranean Fever - physiopathology
Female
Humans
Jews - genetics
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - pathology
Lupus Erythematosus, Systemic - physiopathology
Middle Aged
Pregnancy
Review Literature as Topic
Serositis - physiopathology
title Systemic lupus erythematosus and familial Mediterranean fever: a possible negative association between the two disease entities – report of four cases and review of the literature
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