In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement
The movement of teeth during orthodontic treatment occasionally induces undesirable root resorption. Although high collagenolytic activity has been detected in resorbing tissue of deciduous teeth, the cellular origin of collagenolytic enzymes in root-resorbing tissue caused by tooth movement has not...
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| Veröffentlicht in: | Archives of oral biology 1999-11, Vol.44 (11), p.907-915 |
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| creator | Domon, Sayaka Shimokawa, Hitoyata Matsumoto, Yoshiro Yamaguchi, Satoshi Soma, Kunimichi |
| description | The movement of teeth during orthodontic treatment occasionally induces undesirable root resorption. Although high collagenolytic activity has been detected in resorbing tissue of deciduous teeth, the cellular origin of collagenolytic enzymes in root-resorbing tissue caused by tooth movement has not been identified. Here, rats were subject to 7 days of experimental tooth movement to induce root resorption. In situ hybridization with digoxigenin-labelled RNA probes was performed on sections of the maxillary bone to detect the mRNAs that encode matrix metalloproteinase-1 (MMP-1) and cathepsin K in root-resorbing tissue. MMP-1 mRNA was detected in fibroblastic cells, cementoblasts and osteoblasts, but not in odontoclasts nor osteoclasts. Moreover, MMP-1 mRNA was highly expressed in some cementocytes located near odontoclasts and in many osteocytes. In contrast, cathepsin K mRNA was expressed only in odontoclasts and osteoclasts. These results suggest that MMP-1 and cathepsin K are important in root resorption during tooth movement in a mode similar to bone resorption. |
| doi_str_mv | 10.1016/S0003-9969(99)00091-6 |
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Although high collagenolytic activity has been detected in resorbing tissue of deciduous teeth, the cellular origin of collagenolytic enzymes in root-resorbing tissue caused by tooth movement has not been identified. Here, rats were subject to 7 days of experimental tooth movement to induce root resorption. In situ hybridization with digoxigenin-labelled RNA probes was performed on sections of the maxillary bone to detect the mRNAs that encode matrix metalloproteinase-1 (MMP-1) and cathepsin K in root-resorbing tissue. MMP-1 mRNA was detected in fibroblastic cells, cementoblasts and osteoblasts, but not in odontoclasts nor osteoclasts. Moreover, MMP-1 mRNA was highly expressed in some cementocytes located near odontoclasts and in many osteocytes. In contrast, cathepsin K mRNA was expressed only in odontoclasts and osteoclasts. These results suggest that MMP-1 and cathepsin K are important in root resorption during tooth movement in a mode similar to bone resorption.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/S0003-9969(99)00091-6</identifier><identifier>PMID: 10580538</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bone Resorption - enzymology ; Cathepsin K ; Cathepsins - analysis ; Cathepsins - genetics ; Collagen - metabolism ; Dental Cementum - enzymology ; Dentistry ; Digoxigenin ; Fibroblasts - enzymology ; In Situ Hybridization ; Male ; Matrix Metalloproteinase 1 - analysis ; Matrix Metalloproteinase 1 - genetics ; Matrix metalloproteinase-1 (MMP-1) ; Maxilla - enzymology ; Osteoblasts - enzymology ; Osteoclasts - enzymology ; Osteocytes - enzymology ; Rats ; Rats, Sprague-Dawley ; RNA Probes ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Root resorption ; Root Resorption - enzymology ; Root Resorption - etiology ; Tooth movement ; Tooth Movement Techniques</subject><ispartof>Archives of oral biology, 1999-11, Vol.44 (11), p.907-915</ispartof><rights>1999 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-29c8dbeeeb17a559952e252429d672eed00fbb2e76adf143a7a4bfc22ca5909f3</citedby><cites>FETCH-LOGICAL-c427t-29c8dbeeeb17a559952e252429d672eed00fbb2e76adf143a7a4bfc22ca5909f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0003-9969(99)00091-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10580538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domon, Sayaka</creatorcontrib><creatorcontrib>Shimokawa, Hitoyata</creatorcontrib><creatorcontrib>Matsumoto, Yoshiro</creatorcontrib><creatorcontrib>Yamaguchi, Satoshi</creatorcontrib><creatorcontrib>Soma, Kunimichi</creatorcontrib><title>In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>The movement of teeth during orthodontic treatment occasionally induces undesirable root resorption. Although high collagenolytic activity has been detected in resorbing tissue of deciduous teeth, the cellular origin of collagenolytic enzymes in root-resorbing tissue caused by tooth movement has not been identified. Here, rats were subject to 7 days of experimental tooth movement to induce root resorption. In situ hybridization with digoxigenin-labelled RNA probes was performed on sections of the maxillary bone to detect the mRNAs that encode matrix metalloproteinase-1 (MMP-1) and cathepsin K in root-resorbing tissue. MMP-1 mRNA was detected in fibroblastic cells, cementoblasts and osteoblasts, but not in odontoclasts nor osteoclasts. Moreover, MMP-1 mRNA was highly expressed in some cementocytes located near odontoclasts and in many osteocytes. In contrast, cathepsin K mRNA was expressed only in odontoclasts and osteoclasts. These results suggest that MMP-1 and cathepsin K are important in root resorption during tooth movement in a mode similar to bone resorption.</description><subject>Animals</subject><subject>Bone Resorption - enzymology</subject><subject>Cathepsin K</subject><subject>Cathepsins - analysis</subject><subject>Cathepsins - genetics</subject><subject>Collagen - metabolism</subject><subject>Dental Cementum - enzymology</subject><subject>Dentistry</subject><subject>Digoxigenin</subject><subject>Fibroblasts - enzymology</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Matrix Metalloproteinase 1 - analysis</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix metalloproteinase-1 (MMP-1)</subject><subject>Maxilla - enzymology</subject><subject>Osteoblasts - enzymology</subject><subject>Osteoclasts - enzymology</subject><subject>Osteocytes - enzymology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA Probes</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Root resorption</subject><subject>Root Resorption - enzymology</subject><subject>Root Resorption - etiology</subject><subject>Tooth movement</subject><subject>Tooth Movement Techniques</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEQgC1EVQLtTwD5hOCwxfbG3viEUNQHaiQObc-WH7PEaNcOtheR8ucxBFXcepnRaL6Z0XwIHVPyhRIqLn4RQtpGSiHPpDyvhaSN2EMzuuhkQzkR-2j2DzlAhznf1ZILQT-iA0r4gvB2MUNP1wFnXya83prknf-ri48B9zHhUZfkH_EIRQ9D3KRYwAedoaFYB4etLmvYZB_wT1xD0gWnGEuTIMdkfLjFxec8QW26yYLDZotLBdZ4jA8wQiif0IdeDxk-v-Uj9Ofb19_LH83q5vv18mrV2DnrSsOkXTgDAIZ2mnMpOQPG2ZxJJzoG4AjpjWHQCe16Om91p-emt4xZzSWRfXuETnd76w_3E-SiRp8tDIMOEKeshGwp5ZJWkO9Am2LOCXq1SX7UaasoUS_W1at19aK0BvVqXYk6d_J2YDIjuHdTO80VuNwBUN988JBUth5CteIT2KJc9P858QzJLpTa</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Domon, Sayaka</creator><creator>Shimokawa, Hitoyata</creator><creator>Matsumoto, Yoshiro</creator><creator>Yamaguchi, Satoshi</creator><creator>Soma, Kunimichi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement</title><author>Domon, Sayaka ; Shimokawa, Hitoyata ; Matsumoto, Yoshiro ; Yamaguchi, Satoshi ; Soma, Kunimichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-29c8dbeeeb17a559952e252429d672eed00fbb2e76adf143a7a4bfc22ca5909f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Bone Resorption - enzymology</topic><topic>Cathepsin K</topic><topic>Cathepsins - analysis</topic><topic>Cathepsins - genetics</topic><topic>Collagen - metabolism</topic><topic>Dental Cementum - enzymology</topic><topic>Dentistry</topic><topic>Digoxigenin</topic><topic>Fibroblasts - enzymology</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Matrix Metalloproteinase 1 - analysis</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix metalloproteinase-1 (MMP-1)</topic><topic>Maxilla - enzymology</topic><topic>Osteoblasts - enzymology</topic><topic>Osteoclasts - enzymology</topic><topic>Osteocytes - enzymology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA Probes</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Root resorption</topic><topic>Root Resorption - enzymology</topic><topic>Root Resorption - etiology</topic><topic>Tooth movement</topic><topic>Tooth Movement Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domon, Sayaka</creatorcontrib><creatorcontrib>Shimokawa, Hitoyata</creatorcontrib><creatorcontrib>Matsumoto, Yoshiro</creatorcontrib><creatorcontrib>Yamaguchi, Satoshi</creatorcontrib><creatorcontrib>Soma, Kunimichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domon, Sayaka</au><au>Shimokawa, Hitoyata</au><au>Matsumoto, Yoshiro</au><au>Yamaguchi, Satoshi</au><au>Soma, Kunimichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>44</volume><issue>11</issue><spage>907</spage><epage>915</epage><pages>907-915</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>The movement of teeth during orthodontic treatment occasionally induces undesirable root resorption. Although high collagenolytic activity has been detected in resorbing tissue of deciduous teeth, the cellular origin of collagenolytic enzymes in root-resorbing tissue caused by tooth movement has not been identified. Here, rats were subject to 7 days of experimental tooth movement to induce root resorption. In situ hybridization with digoxigenin-labelled RNA probes was performed on sections of the maxillary bone to detect the mRNAs that encode matrix metalloproteinase-1 (MMP-1) and cathepsin K in root-resorbing tissue. MMP-1 mRNA was detected in fibroblastic cells, cementoblasts and osteoblasts, but not in odontoclasts nor osteoclasts. Moreover, MMP-1 mRNA was highly expressed in some cementocytes located near odontoclasts and in many osteocytes. In contrast, cathepsin K mRNA was expressed only in odontoclasts and osteoclasts. These results suggest that MMP-1 and cathepsin K are important in root resorption during tooth movement in a mode similar to bone resorption.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10580538</pmid><doi>10.1016/S0003-9969(99)00091-6</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Bone Resorption - enzymology Cathepsin K Cathepsins - analysis Cathepsins - genetics Collagen - metabolism Dental Cementum - enzymology Dentistry Digoxigenin Fibroblasts - enzymology In Situ Hybridization Male Matrix Metalloproteinase 1 - analysis Matrix Metalloproteinase 1 - genetics Matrix metalloproteinase-1 (MMP-1) Maxilla - enzymology Osteoblasts - enzymology Osteoclasts - enzymology Osteocytes - enzymology Rats Rats, Sprague-Dawley RNA Probes RNA, Messenger - analysis RNA, Messenger - genetics Root resorption Root Resorption - enzymology Root Resorption - etiology Tooth movement Tooth Movement Techniques |
| title | In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement |
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