Biaryl Synthesis via Decarboxylative Pd-Catalyzed Reactions of Arenecarboxylic Acids and Diaryliodonium Triflates
A novel simple and efficient synthesis of biaryls via a Pd-catalyzed decarboxylative cross-coupling reaction of arenecarboxylic acids and diaryliodonium triflates is described. The PdCl2/DPEphos catalytic system in the presence of Ag2CO3 in DMSO was found to be the most efficient. Various biaryls, i...
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| Veröffentlicht in: | Organic letters 2008-07, Vol.10 (14), p.3161-3164 |
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| container_title | Organic letters |
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| creator | Becht, Jean-Michel Drian, Claude Le |
| description | A novel simple and efficient synthesis of biaryls via a Pd-catalyzed decarboxylative cross-coupling reaction of arenecarboxylic acids and diaryliodonium triflates is described. The PdCl2/DPEphos catalytic system in the presence of Ag2CO3 in DMSO was found to be the most efficient. Various biaryls, including sterically hindered biaryls, were synthesized with yields ranging from 37 to 85%. |
| doi_str_mv | 10.1021/ol8011293 |
| format | Article |
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| ispartof | Organic letters, 2008-07, Vol.10 (14), p.3161-3164 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69311506 |
| source | MEDLINE; ACS Publications |
| subjects | Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Combinatorial Chemistry Techniques Indicators and Reagents Mesylates - chemical synthesis Mesylates - chemistry Molecular Structure Palladium - chemistry |
| title | Biaryl Synthesis via Decarboxylative Pd-Catalyzed Reactions of Arenecarboxylic Acids and Diaryliodonium Triflates |
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