Progesterone, Estrogen and Pregnancy Do Not Decrease Colon Myoelectric Activity in Rats: An in vivo Study
Background: Progesterone, estrogen and the hormonal complex of pregnancy have been responsible for some degree of colon hypomotility in human pregnancy. Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 2008-01, Vol.66 (1), p.53-58 |
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| creator | Speranzini, L.B.M. Lopasso, P.P. Laudanna, A.A. |
| description | Background: Progesterone, estrogen and the hormonal complex of pregnancy have been responsible for some degree of colon hypomotility in human pregnancy. Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was performed in 37 healthy female rats in which electrodes were implanted on the serosa of the proximal ascendent, distal ascendent, transverse, and descendent colon. We analyzed the records of colon myoelectric activity in vivo in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone, and pregnant rats. Results: We found a great variation in myoelectric activity in all groups studied. The mean of electric activity did not show statistical difference among the five groups, but pregnant rats had a statistically significant higher duration of maximum electric activity in all distances from the cecocolon junction. Conclusion: Pregnant rats had a statistically higher duration of maximum electric activity. If we could transpose these results to humans, this increase in duration of colon myoelectric activity could explain, in part, the slight constipation that some pregnant women have. |
| doi_str_mv | 10.1159/000119643 |
| format | Article |
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Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was performed in 37 healthy female rats in which electrodes were implanted on the serosa of the proximal ascendent, distal ascendent, transverse, and descendent colon. We analyzed the records of colon myoelectric activity in vivo in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone, and pregnant rats. Results: We found a great variation in myoelectric activity in all groups studied. The mean of electric activity did not show statistical difference among the five groups, but pregnant rats had a statistically significant higher duration of maximum electric activity in all distances from the cecocolon junction. Conclusion: Pregnant rats had a statistically higher duration of maximum electric activity. If we could transpose these results to humans, this increase in duration of colon myoelectric activity could explain, in part, the slight constipation that some pregnant women have.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000119643</identifier><identifier>PMID: 18319603</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Biological and medical sciences ; Colon - physiology ; Estrogens - physiology ; Female ; Gynecology. Andrology. Obstetrics ; Medical sciences ; Models, Animal ; Myoelectric Complex, Migrating - physiology ; Original Article ; Pregnancy - physiology ; Progesterone - physiology ; Rats ; Rats, Wistar</subject><ispartof>Gynecologic and obstetric investigation, 2008-01, Vol.66 (1), p.53-58</ispartof><rights>2008 S. Karger AG, Basel</rights><rights>2008 INIST-CNRS</rights><rights>Copyright 2008 S. 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Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was performed in 37 healthy female rats in which electrodes were implanted on the serosa of the proximal ascendent, distal ascendent, transverse, and descendent colon. We analyzed the records of colon myoelectric activity in vivo in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone, and pregnant rats. Results: We found a great variation in myoelectric activity in all groups studied. The mean of electric activity did not show statistical difference among the five groups, but pregnant rats had a statistically significant higher duration of maximum electric activity in all distances from the cecocolon junction. Conclusion: Pregnant rats had a statistically higher duration of maximum electric activity. 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Obstetrics</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Myoelectric Complex, Migrating - physiology</subject><subject>Original Article</subject><subject>Pregnancy - physiology</subject><subject>Progesterone - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0F1rFDEUBuAgil2rF96LhIKC4GgyZyYz8W7Z1lZoa_EDvBsymZMldTapSWZh_r1Zd2nBqyTw8J6Tl5CXnH3gvJYfGWOcS1HBI7LgVQkFY-Wvx2TBoGmLBipxRJ7FeJtVLdvqKTniLWTPYEHsTfBrjAmDd_iensW0ezuq3EBvAq6dcnqmp55e-0RPUQdUEenKj97Rq9njiDoFq-lSJ7u1aabW0W8qxU906Xb3rd16-j1Nw_ycPDFqjPjicB6Tn5_Pfqwuisuv519Wy8tCg-CpaDXUvawYKF03om8ZSKWUkcJAL4bBIJY96l4ZLA0KwFYaqQctamQ10xLgmLzd594F_2fKX-s2NmocR-XQT7ETEjhn_-DJf_DWT8Hl3bqyhEZwKZuM3u2RDj7GgKa7C3ajwtxx1u3K7-7Lz_b1IXDqNzg8yEPbGbw5ABW1Gk3I5dp470pWQ9VInt2rvfutwhrDQ9B-zl_eHJT-</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Speranzini, L.B.M.</creator><creator>Lopasso, P.P.</creator><creator>Laudanna, A.A.</creator><general>Karger</general><general>S. 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Objective: To find out if estrogen, progesterone and the hormonal complex of pregnancy decrease colon myoelectric activity. Methods: The study was performed in 37 healthy female rats in which electrodes were implanted on the serosa of the proximal ascendent, distal ascendent, transverse, and descendent colon. We analyzed the records of colon myoelectric activity in vivo in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone, and pregnant rats. Results: We found a great variation in myoelectric activity in all groups studied. The mean of electric activity did not show statistical difference among the five groups, but pregnant rats had a statistically significant higher duration of maximum electric activity in all distances from the cecocolon junction. Conclusion: Pregnant rats had a statistically higher duration of maximum electric activity. If we could transpose these results to humans, this increase in duration of colon myoelectric activity could explain, in part, the slight constipation that some pregnant women have.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>18319603</pmid><doi>10.1159/000119643</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Colon - physiology Estrogens - physiology Female Gynecology. Andrology. Obstetrics Medical sciences Models, Animal Myoelectric Complex, Migrating - physiology Original Article Pregnancy - physiology Progesterone - physiology Rats Rats, Wistar |
| title | Progesterone, Estrogen and Pregnancy Do Not Decrease Colon Myoelectric Activity in Rats: An in vivo Study |
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