Gap Junction Communication and the Modulation of Cardiac Neural Crest Cells
The analyses of transgenic and knockout mice with perturbations in α 1 connexin (Cx43) function have revealed an important role for gap junctions in cardiac development. This likely involves the modulation of cardiac crest migration and function. Studies carried out with these mouse models suggest t...
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| Veröffentlicht in: | Trends in Cardiovascular Medicine 1999-04, Vol.9 (3), p.63-69 |
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| container_title | Trends in Cardiovascular Medicine |
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| creator | Lo, Cecilia W Waldo, Karen L Kirby, Margaret L |
| description | The analyses of transgenic and knockout mice with perturbations in α
1 connexin (Cx43) function have revealed an important role for gap junctions in cardiac development. This likely involves the modulation of cardiac crest migration and function. Studies carried out with these mouse models suggest that clinically there may be a novel category of cardiac defects involving crest perturbations that do not include outflow septation defects, but rather involve more subtle defects in the pulmonary outflow tract. |
| doi_str_mv | 10.1016/S1050-1738(99)00015-8 |
| format | Article |
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1 connexin (Cx43) function have revealed an important role for gap junctions in cardiac development. This likely involves the modulation of cardiac crest migration and function. Studies carried out with these mouse models suggest that clinically there may be a novel category of cardiac defects involving crest perturbations that do not include outflow septation defects, but rather involve more subtle defects in the pulmonary outflow tract.</description><subject>Animals</subject><subject>Cell Division</subject><subject>Connexin 43 - metabolism</subject><subject>Gap Junctions - physiology</subject><subject>Heart - growth & development</subject><subject>Heart - innervation</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Myocardium - cytology</subject><subject>Myocardium - metabolism</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - metabolism</subject><subject>Signal Transduction - physiology</subject><issn>1050-1738</issn><issn>1873-2615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOxCAUhonROOPlETRdGV1UOW0psDKm0fEy6kJdE4ZCxLRlhNbEt5eZjok7V9y-w3_Oh9AR4HPAUF68ACY4BZqzU87PMMZAUraFpsBonmYlkO24_0UmaC-EjwiVRQm7aBIfKCPAp-hhJpfJ_dCp3rouqVzbDp1Vcn2SXZ307zp5dPXQjFfOJJX0tZUqedKDl01SeR36pNJNEw7QjpFN0IebdR-93Vy_Vrfp_Hl2V13NU1XQok-zHBtQPCeQGaaNVgarBaNFWS4McE6VWYAqKcM1NQSwwRmXBQdmMg1AAPJ9dDL-u_Tuc4jxorVBxQ5kp90QRMlzwDldgWQElXcheG3E0ttW-m8BWKwsirVFsVIkOBdri4LFuuNNwLBodf2natQWgcsR0HHML6u9CMrqTunaeq16UTv7T8QPQPWAXQ</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Lo, Cecilia W</creator><creator>Waldo, Karen L</creator><creator>Kirby, Margaret L</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Gap Junction Communication and the Modulation of Cardiac Neural Crest Cells</title><author>Lo, Cecilia W ; Waldo, Karen L ; Kirby, Margaret L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-230f1c93512f8efecf0cb87466bf1997cfb1c6780d7f510f029a4918f2e115113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Cell Division</topic><topic>Connexin 43 - metabolism</topic><topic>Gap Junctions - physiology</topic><topic>Heart - growth & development</topic><topic>Heart - innervation</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Myocardium - cytology</topic><topic>Myocardium - metabolism</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - metabolism</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Cecilia W</creatorcontrib><creatorcontrib>Waldo, Karen L</creatorcontrib><creatorcontrib>Kirby, Margaret L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Cardiovascular Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Cecilia W</au><au>Waldo, Karen L</au><au>Kirby, Margaret L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gap Junction Communication and the Modulation of Cardiac Neural Crest Cells</atitle><jtitle>Trends in Cardiovascular Medicine</jtitle><addtitle>Trends Cardiovasc Med</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>9</volume><issue>3</issue><spage>63</spage><epage>69</epage><pages>63-69</pages><issn>1050-1738</issn><eissn>1873-2615</eissn><abstract>The analyses of transgenic and knockout mice with perturbations in α
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| ispartof | Trends in Cardiovascular Medicine, 1999-04, Vol.9 (3), p.63-69 |
| issn | 1050-1738 1873-2615 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69310371 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Division Connexin 43 - metabolism Gap Junctions - physiology Heart - growth & development Heart - innervation Mice Mice, Knockout Mice, Transgenic Myocardium - cytology Myocardium - metabolism Neural Crest - cytology Neural Crest - metabolism Signal Transduction - physiology |
| title | Gap Junction Communication and the Modulation of Cardiac Neural Crest Cells |
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