Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis
Objective: To investigate associations between nonsyndromic oral clefts and biochemical measures of folate status and the MTHFR C677T variant in the United Kingdom, where there has been no folic acid fortification program. Method: Dietary details were obtained from the mothers of 112 cases of cleft...
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| Veröffentlicht in: | The Cleft palate-craniofacial journal 2008-07, Vol.45 (4), p.428-438 |
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| container_title | The Cleft palate-craniofacial journal |
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| creator | Little, J. Gilmour, M. Mossey, P. A. FitzPatrick, D. Cardy, A. Clayton-Smith, J. Hill, A. Duthie, S. J. Fryer, A. E. Molloy, A. M. Scott, J. M. |
| description | Objective:
To investigate associations between nonsyndromic oral clefts and biochemical measures of folate status and the MTHFR C677T variant in the United Kingdom, where there has been no folic acid fortification program.
Method:
Dietary details were obtained from the mothers of 112 cases of cleft lip with or without cleft palate (CL±P), 78 cleft palate only (CP) cases, and 248 unaffected infants. Infant and parental MTHFR C677T genotype was determined. Red blood cell (RBC) and serum folate and homocysteine levels were assessed in 12-month postpartum blood samples from a subset of mothers. The data were analyzed by logistic and log-linear regression methods.
Results:
There was an inverse association between CL±P and maternal MTHFR CT (odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.31–0.95) and TT (OR = 0.6, 95% CI = 0.21–1.50) genotypes, with similar risk estimates for CP. There was no clear association with infant MTHFR genotype. Higher levels of maternal postpartum RBC and serum folate were associated with a lower risk for CL±P and an increased risk for CP. Higher levels of serum homocysteine were associated with a slightly increased risk for both CL±P and CP.
Conclusion:
While the inverse relation between the mother's having the MTHFR C677T variant and both CL±P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain. |
| doi_str_mv | 10.1597/06-151.1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69307097</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1597_06-151.1</sage_id><sourcerecordid>69307097</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-3250e64c993dc6747b06c803fc8d6d1e49e2b9323d38421f58f73e562ea8d913</originalsourceid><addsrcrecordid>eNpl0c1q3DAQAGBRWpqfFvoERRQaevFWv2Mrt83SpEsWWmh6Nlp53Dh4ra0kH_aWh8gT9kmq3ZgGmotGIz5mhhEh7zibcW3KzwwKrvmMvyDHXCudEzAv851pXQBoOCInMd4xJjQX1WtyxCvgIEEck3Tpe5uQ2qGhix7bFKlvabpFuuq2h9fvdg_-3D_M6c_Z9ay4sBGzzWex8EMKvqc_0tjszrMMiS6X5_Si8-4WN52z_aHEFQ6YOkfng-13sYtvyKvW9hHfTvGU3Fx-uVl8LVbfrpaL-apwSqpUSKEZgnLGyMZBqco1A1cx2bqqgYajMijWRgrZyEoJ3uqqLSVqEGirxnB5Ss4ey26D_z1iTPWmiw773g7ox1iDkaxkpszww3_wzo8hDxtrwZQRqpKQ0adH5IKPMWBbb0O3sWFXc1bvf6FmkCOv943fT_XG9QabJzitPYOPE7AxL6kNdnBd_OcE00zBYbDJRfsLn4Z61vAv0uWXbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204924836</pqid></control><display><type>article</type><title>Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Little, J. ; Gilmour, M. ; Mossey, P. A. ; FitzPatrick, D. ; Cardy, A. ; Clayton-Smith, J. ; Hill, A. ; Duthie, S. J. ; Fryer, A. E. ; Molloy, A. M. ; Scott, J. M.</creator><creatorcontrib>Little, J. ; Gilmour, M. ; Mossey, P. A. ; FitzPatrick, D. ; Cardy, A. ; Clayton-Smith, J. ; Hill, A. ; Duthie, S. J. ; Fryer, A. E. ; Molloy, A. M. ; Scott, J. M. ; ITS MAGIC Collaboration</creatorcontrib><description>Objective:
To investigate associations between nonsyndromic oral clefts and biochemical measures of folate status and the MTHFR C677T variant in the United Kingdom, where there has been no folic acid fortification program.
Method:
Dietary details were obtained from the mothers of 112 cases of cleft lip with or without cleft palate (CL±P), 78 cleft palate only (CP) cases, and 248 unaffected infants. Infant and parental MTHFR C677T genotype was determined. Red blood cell (RBC) and serum folate and homocysteine levels were assessed in 12-month postpartum blood samples from a subset of mothers. The data were analyzed by logistic and log-linear regression methods.
Results:
There was an inverse association between CL±P and maternal MTHFR CT (odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.31–0.95) and TT (OR = 0.6, 95% CI = 0.21–1.50) genotypes, with similar risk estimates for CP. There was no clear association with infant MTHFR genotype. Higher levels of maternal postpartum RBC and serum folate were associated with a lower risk for CL±P and an increased risk for CP. Higher levels of serum homocysteine were associated with a slightly increased risk for both CL±P and CP.
Conclusion:
While the inverse relation between the mother's having the MTHFR C677T variant and both CL±P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain.</description><identifier>ISSN: 1055-6656</identifier><identifier>EISSN: 1545-1569</identifier><identifier>DOI: 10.1597/06-151.1</identifier><identifier>PMID: 18616362</identifier><identifier>CODEN: CPJOEG</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Biological and medical sciences ; Case-Control Studies ; Cleft Lip - genetics ; Cleft Palate - genetics ; Deformities ; Dentistry ; Dietary supplements ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Fathers ; Female ; Folic Acid - blood ; Gene Frequency ; Genetic testing ; Homocysteine - blood ; Humans ; Infant, Newborn ; Male ; Medical research ; Medical sciences ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Mothers ; Mouth ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Polymorphism, Single Nucleotide ; Pregnancy ; Regression Analysis ; Surveys and Questionnaires ; United Kingdom ; Vitamin B</subject><ispartof>The Cleft palate-craniofacial journal, 2008-07, Vol.45 (4), p.428-438</ispartof><rights>2008 American Cleft Palate-Craniofacial Association</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Allen Press Publishing Services Jul 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-3250e64c993dc6747b06c803fc8d6d1e49e2b9323d38421f58f73e562ea8d913</citedby><cites>FETCH-LOGICAL-c434t-3250e64c993dc6747b06c803fc8d6d1e49e2b9323d38421f58f73e562ea8d913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1597/06-151.1$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1597/06-151.1$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20504697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18616362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Little, J.</creatorcontrib><creatorcontrib>Gilmour, M.</creatorcontrib><creatorcontrib>Mossey, P. A.</creatorcontrib><creatorcontrib>FitzPatrick, D.</creatorcontrib><creatorcontrib>Cardy, A.</creatorcontrib><creatorcontrib>Clayton-Smith, J.</creatorcontrib><creatorcontrib>Hill, A.</creatorcontrib><creatorcontrib>Duthie, S. J.</creatorcontrib><creatorcontrib>Fryer, A. E.</creatorcontrib><creatorcontrib>Molloy, A. M.</creatorcontrib><creatorcontrib>Scott, J. M.</creatorcontrib><creatorcontrib>ITS MAGIC Collaboration</creatorcontrib><title>Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis</title><title>The Cleft palate-craniofacial journal</title><addtitle>Cleft Palate Craniofac J</addtitle><description>Objective:
To investigate associations between nonsyndromic oral clefts and biochemical measures of folate status and the MTHFR C677T variant in the United Kingdom, where there has been no folic acid fortification program.
Method:
Dietary details were obtained from the mothers of 112 cases of cleft lip with or without cleft palate (CL±P), 78 cleft palate only (CP) cases, and 248 unaffected infants. Infant and parental MTHFR C677T genotype was determined. Red blood cell (RBC) and serum folate and homocysteine levels were assessed in 12-month postpartum blood samples from a subset of mothers. The data were analyzed by logistic and log-linear regression methods.
Results:
There was an inverse association between CL±P and maternal MTHFR CT (odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.31–0.95) and TT (OR = 0.6, 95% CI = 0.21–1.50) genotypes, with similar risk estimates for CP. There was no clear association with infant MTHFR genotype. Higher levels of maternal postpartum RBC and serum folate were associated with a lower risk for CL±P and an increased risk for CP. Higher levels of serum homocysteine were associated with a slightly increased risk for both CL±P and CP.
Conclusion:
While the inverse relation between the mother's having the MTHFR C677T variant and both CL±P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain.</description><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cleft Lip - genetics</subject><subject>Cleft Palate - genetics</subject><subject>Deformities</subject><subject>Dentistry</subject><subject>Dietary supplements</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Fathers</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Gene Frequency</subject><subject>Genetic testing</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Mothers</subject><subject>Mouth</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Regression Analysis</subject><subject>Surveys and Questionnaires</subject><subject>United Kingdom</subject><subject>Vitamin B</subject><issn>1055-6656</issn><issn>1545-1569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpl0c1q3DAQAGBRWpqfFvoERRQaevFWv2Mrt83SpEsWWmh6Nlp53Dh4ra0kH_aWh8gT9kmq3ZgGmotGIz5mhhEh7zibcW3KzwwKrvmMvyDHXCudEzAv851pXQBoOCInMd4xJjQX1WtyxCvgIEEck3Tpe5uQ2qGhix7bFKlvabpFuuq2h9fvdg_-3D_M6c_Z9ay4sBGzzWex8EMKvqc_0tjszrMMiS6X5_Si8-4WN52z_aHEFQ6YOkfng-13sYtvyKvW9hHfTvGU3Fx-uVl8LVbfrpaL-apwSqpUSKEZgnLGyMZBqco1A1cx2bqqgYajMijWRgrZyEoJ3uqqLSVqEGirxnB5Ss4ey26D_z1iTPWmiw773g7ox1iDkaxkpszww3_wzo8hDxtrwZQRqpKQ0adH5IKPMWBbb0O3sWFXc1bvf6FmkCOv943fT_XG9QabJzitPYOPE7AxL6kNdnBd_OcE00zBYbDJRfsLn4Z61vAv0uWXbw</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Little, J.</creator><creator>Gilmour, M.</creator><creator>Mossey, P. A.</creator><creator>FitzPatrick, D.</creator><creator>Cardy, A.</creator><creator>Clayton-Smith, J.</creator><creator>Hill, A.</creator><creator>Duthie, S. J.</creator><creator>Fryer, A. E.</creator><creator>Molloy, A. M.</creator><creator>Scott, J. M.</creator><general>SAGE Publications</general><general>American Cleft Palate-Craniofacial Association</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M3G</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis</title><author>Little, J. ; Gilmour, M. ; Mossey, P. A. ; FitzPatrick, D. ; Cardy, A. ; Clayton-Smith, J. ; Hill, A. ; Duthie, S. J. ; Fryer, A. E. ; Molloy, A. M. ; Scott, J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-3250e64c993dc6747b06c803fc8d6d1e49e2b9323d38421f58f73e562ea8d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cleft Lip - genetics</topic><topic>Cleft Palate - genetics</topic><topic>Deformities</topic><topic>Dentistry</topic><topic>Dietary supplements</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Fathers</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Gene Frequency</topic><topic>Genetic testing</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Mothers</topic><topic>Mouth</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Regression Analysis</topic><topic>Surveys and Questionnaires</topic><topic>United Kingdom</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Little, J.</creatorcontrib><creatorcontrib>Gilmour, M.</creatorcontrib><creatorcontrib>Mossey, P. A.</creatorcontrib><creatorcontrib>FitzPatrick, D.</creatorcontrib><creatorcontrib>Cardy, A.</creatorcontrib><creatorcontrib>Clayton-Smith, J.</creatorcontrib><creatorcontrib>Hill, A.</creatorcontrib><creatorcontrib>Duthie, S. J.</creatorcontrib><creatorcontrib>Fryer, A. E.</creatorcontrib><creatorcontrib>Molloy, A. M.</creatorcontrib><creatorcontrib>Scott, J. M.</creatorcontrib><creatorcontrib>ITS MAGIC Collaboration</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>CBCA Reference & Current Events</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Cleft palate-craniofacial journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Little, J.</au><au>Gilmour, M.</au><au>Mossey, P. A.</au><au>FitzPatrick, D.</au><au>Cardy, A.</au><au>Clayton-Smith, J.</au><au>Hill, A.</au><au>Duthie, S. J.</au><au>Fryer, A. E.</au><au>Molloy, A. M.</au><au>Scott, J. M.</au><aucorp>ITS MAGIC Collaboration</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis</atitle><jtitle>The Cleft palate-craniofacial journal</jtitle><addtitle>Cleft Palate Craniofac J</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>45</volume><issue>4</issue><spage>428</spage><epage>438</epage><pages>428-438</pages><issn>1055-6656</issn><eissn>1545-1569</eissn><coden>CPJOEG</coden><abstract>Objective:
To investigate associations between nonsyndromic oral clefts and biochemical measures of folate status and the MTHFR C677T variant in the United Kingdom, where there has been no folic acid fortification program.
Method:
Dietary details were obtained from the mothers of 112 cases of cleft lip with or without cleft palate (CL±P), 78 cleft palate only (CP) cases, and 248 unaffected infants. Infant and parental MTHFR C677T genotype was determined. Red blood cell (RBC) and serum folate and homocysteine levels were assessed in 12-month postpartum blood samples from a subset of mothers. The data were analyzed by logistic and log-linear regression methods.
Results:
There was an inverse association between CL±P and maternal MTHFR CT (odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.31–0.95) and TT (OR = 0.6, 95% CI = 0.21–1.50) genotypes, with similar risk estimates for CP. There was no clear association with infant MTHFR genotype. Higher levels of maternal postpartum RBC and serum folate were associated with a lower risk for CL±P and an increased risk for CP. Higher levels of serum homocysteine were associated with a slightly increased risk for both CL±P and CP.
Conclusion:
While the inverse relation between the mother's having the MTHFR C677T variant and both CL±P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>18616362</pmid><doi>10.1597/06-151.1</doi><tpages>11</tpages></addata></record> |
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| ispartof | The Cleft palate-craniofacial journal, 2008-07, Vol.45 (4), p.428-438 |
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| subjects | Biological and medical sciences Case-Control Studies Cleft Lip - genetics Cleft Palate - genetics Deformities Dentistry Dietary supplements Facial bones, jaws, teeth, parodontium: diseases, semeiology Fathers Female Folic Acid - blood Gene Frequency Genetic testing Homocysteine - blood Humans Infant, Newborn Male Medical research Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Mothers Mouth Non tumoral diseases Otorhinolaryngology. Stomatology Polymorphism, Single Nucleotide Pregnancy Regression Analysis Surveys and Questionnaires United Kingdom Vitamin B |
| title | Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part II: Biochemical and Genetic Analysis |
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