c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

Smads are intracellular signaling mediators of the transforming growth factor-beta (TGF-beta) superfamily that regulates a wide variety of biological processes. Among them, Smads 2 and 3 are activated specifically by TGF-beta. We identified c-Ski as a Smad2 interacting protein. c-Ski is the cellular...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (49), p.35269-35277
Hauptverfasser:	Akiyoshi, S, Inoue, H, Hanai, J, Kusanagi, K, Nemoto, N, Miyazono, K, Kawabata, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - metabolism Animals c-Ski protein Cell Line COS Cells DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Histone Acetyltransferases histone deacetylase Histone Deacetylase 1 Histone Deacetylases - metabolism Immunoblotting Mink Nuclear Proteins - metabolism p300 protein Plasmids - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Saccharomyces cerevisiae Proteins Signal Transduction Smad2 Protein Smad3 Protein Trans-Activators - metabolism Transcription, Genetic Transfection Transforming Growth Factor beta - metabolism Two-Hybrid System Techniques v-ski gene
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