A combined genotype of KIR3DL1 high expressing alleles and HLA-B57 is associated with a reduced risk of HIV infection
Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection in terms of disease outcome in KIR3DL1 homozygotes (3DL1 hmz) is coexpression of HLA-B*57 and a set of KIR3DL1 genotypes (3DL1*h/*y) lacking...
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| Veröffentlicht in: | AIDS (London) 2008-07, Vol.22 (12), p.1487-1491 |
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| creator | BOULET, Salix KLEYMAN, Marianna KIM, Jenice Y. J KAMYA, Philomena SHARAFI, Saeid SIMIC, Nancy BRUNEAU, Julie ROUTY, Jean-Pierre TSOUKAS, Christos M BERNARD, Nicole F |
| description | Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection in terms of disease outcome in KIR3DL1 homozygotes (3DL1 hmz) is coexpression of HLA-B*57 and a set of KIR3DL1 genotypes (3DL1*h/*y) lacking alleles expressed at low levels on natural killer cells. We questioned whether this allele combination could also influence resistance to infection.
The genetic distribution of 3DL1*h/*y and HLA-B*57 was compared in 41 HIV-exposed uninfected and 186 recently HIV-infected 3DL1 hmz.
KIR3DL1 subtyping was performed by sequencing the exons 3, 4, 5, 7-9. The major histocompatibility complex class IB locus was typed by sequence specific oligonucleotide PCR and sequencing to resolve Bw4 and Bw6 alleles and the amino acid present at position 80.
Percentage carriers of HLA-B*57 in HIV-exposed uninfected and individuals in a primary infection cohort was 12.2 and 4.3%, respectively (P = 0.0631), whereas that of 3DL1*h/*y was similar in both populations (P = 0.221). The 3DL1*h/*y-HLA-B*57 combined genotype was more frequent in exposed uninfected individuals (12.2%) than individuals in primary infection (2.7%) (P = 0.019; odds ratio, 5.03; 95% confidence intervals, 1.38-18.3).
Coexpression of 3DL1*h/*y and B*57, which has been associated with a reduced risk of progressing to AIDS in HIV-infected individuals also lowers the risk of HIV infection in exposed uninfected individuals. |
| doi_str_mv | 10.1097/QAD.0b013e3282ffde7e |
| format | Article |
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The genetic distribution of 3DL1*h/*y and HLA-B*57 was compared in 41 HIV-exposed uninfected and 186 recently HIV-infected 3DL1 hmz.
KIR3DL1 subtyping was performed by sequencing the exons 3, 4, 5, 7-9. The major histocompatibility complex class IB locus was typed by sequence specific oligonucleotide PCR and sequencing to resolve Bw4 and Bw6 alleles and the amino acid present at position 80.
Percentage carriers of HLA-B*57 in HIV-exposed uninfected and individuals in a primary infection cohort was 12.2 and 4.3%, respectively (P = 0.0631), whereas that of 3DL1*h/*y was similar in both populations (P = 0.221). The 3DL1*h/*y-HLA-B*57 combined genotype was more frequent in exposed uninfected individuals (12.2%) than individuals in primary infection (2.7%) (P = 0.019; odds ratio, 5.03; 95% confidence intervals, 1.38-18.3).
Coexpression of 3DL1*h/*y and B*57, which has been associated with a reduced risk of progressing to AIDS in HIV-infected individuals also lowers the risk of HIV infection in exposed uninfected individuals.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0b013e3282ffde7e</identifier><identifier>PMID: 18614872</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>AIDS/HIV ; Alleles ; Biological and medical sciences ; Cells, Cultured ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HIV Infections - genetics ; HIV Infections - immunology ; HIV-1 ; HLA-B Antigens - genetics ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunity, Innate - genetics ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Medical sciences ; Receptors, KIR3DL1 - genetics ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2008-07, Vol.22 (12), p.1487-1491</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-79b61d60ac630c112d84c42f29d7403ff1a6e4c7d7914303aef31d99302e046e3</citedby><cites>FETCH-LOGICAL-c412t-79b61d60ac630c112d84c42f29d7403ff1a6e4c7d7914303aef31d99302e046e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20551001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18614872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOULET, Salix</creatorcontrib><creatorcontrib>KLEYMAN, Marianna</creatorcontrib><creatorcontrib>KIM, Jenice Y. J</creatorcontrib><creatorcontrib>KAMYA, Philomena</creatorcontrib><creatorcontrib>SHARAFI, Saeid</creatorcontrib><creatorcontrib>SIMIC, Nancy</creatorcontrib><creatorcontrib>BRUNEAU, Julie</creatorcontrib><creatorcontrib>ROUTY, Jean-Pierre</creatorcontrib><creatorcontrib>TSOUKAS, Christos M</creatorcontrib><creatorcontrib>BERNARD, Nicole F</creatorcontrib><title>A combined genotype of KIR3DL1 high expressing alleles and HLA-B57 is associated with a reduced risk of HIV infection</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection in terms of disease outcome in KIR3DL1 homozygotes (3DL1 hmz) is coexpression of HLA-B*57 and a set of KIR3DL1 genotypes (3DL1*h/*y) lacking alleles expressed at low levels on natural killer cells. We questioned whether this allele combination could also influence resistance to infection.
The genetic distribution of 3DL1*h/*y and HLA-B*57 was compared in 41 HIV-exposed uninfected and 186 recently HIV-infected 3DL1 hmz.
KIR3DL1 subtyping was performed by sequencing the exons 3, 4, 5, 7-9. The major histocompatibility complex class IB locus was typed by sequence specific oligonucleotide PCR and sequencing to resolve Bw4 and Bw6 alleles and the amino acid present at position 80.
Percentage carriers of HLA-B*57 in HIV-exposed uninfected and individuals in a primary infection cohort was 12.2 and 4.3%, respectively (P = 0.0631), whereas that of 3DL1*h/*y was similar in both populations (P = 0.221). The 3DL1*h/*y-HLA-B*57 combined genotype was more frequent in exposed uninfected individuals (12.2%) than individuals in primary infection (2.7%) (P = 0.019; odds ratio, 5.03; 95% confidence intervals, 1.38-18.3).
Coexpression of 3DL1*h/*y and B*57, which has been associated with a reduced risk of progressing to AIDS in HIV-infected individuals also lowers the risk of HIV infection in exposed uninfected individuals.</description><subject>AIDS/HIV</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HLA-B Antigens - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunity, Innate - genetics</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Receptors, KIR3DL1 - genetics</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQRy0EoqHwDRDyBW5bZvx39xhaSiIiIRBwXTn2ODFsdtP1rmi_Pa4agcSF02ik93uXx9hLhAuExr79vLy6gC2gJClqEWMgS4_YApWVldYWH7MFCNNUjbRwxp7l_AMANNT1U3aGtUFVW7Fg85L74bBNPQW-o36Y7o7Eh8g_rr_Iqw3yfdrtOd0eR8o59Tvuuo46ytz1ga82y-qdtjyVN-fBJzcVy6807bnjI4XZl3dM-ee9cLX-zlMfyU9p6J-zJ9F1mV6c7jn7dv3-6-Wq2nz6sL5cbiqvUEyVbbYGgwHnjQSPKEKtvBJRNMEqkDGiM6S8DbZBJUE6ihJD00gQBMqQPGdvHrzHcbiZKU_tIWVPXed6GubcmoJqW5v_gthoLVDLAqoH0I9DziPF9jimgxvvWoT2vktburT_dimzVyf_vD1Q-Ds6hSjA6xPgsnddHF3vU_7DCdAaoUh_A-jNlbM</recordid><startdate>20080731</startdate><enddate>20080731</enddate><creator>BOULET, Salix</creator><creator>KLEYMAN, Marianna</creator><creator>KIM, Jenice Y. 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Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Receptors, KIR3DL1 - genetics</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOULET, Salix</creatorcontrib><creatorcontrib>KLEYMAN, Marianna</creatorcontrib><creatorcontrib>KIM, Jenice Y. J</creatorcontrib><creatorcontrib>KAMYA, Philomena</creatorcontrib><creatorcontrib>SHARAFI, Saeid</creatorcontrib><creatorcontrib>SIMIC, Nancy</creatorcontrib><creatorcontrib>BRUNEAU, Julie</creatorcontrib><creatorcontrib>ROUTY, Jean-Pierre</creatorcontrib><creatorcontrib>TSOUKAS, Christos M</creatorcontrib><creatorcontrib>BERNARD, Nicole F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOULET, Salix</au><au>KLEYMAN, Marianna</au><au>KIM, Jenice Y. J</au><au>KAMYA, Philomena</au><au>SHARAFI, Saeid</au><au>SIMIC, Nancy</au><au>BRUNEAU, Julie</au><au>ROUTY, Jean-Pierre</au><au>TSOUKAS, Christos M</au><au>BERNARD, Nicole F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A combined genotype of KIR3DL1 high expressing alleles and HLA-B57 is associated with a reduced risk of HIV infection</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2008-07-31</date><risdate>2008</risdate><volume>22</volume><issue>12</issue><spage>1487</spage><epage>1491</epage><pages>1487-1491</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>Coexpression of certain combinations of natural killer cell receptor KIR3DL1 and HLA-B alleles is associated with slower time to AIDS. The strongest protection in terms of disease outcome in KIR3DL1 homozygotes (3DL1 hmz) is coexpression of HLA-B*57 and a set of KIR3DL1 genotypes (3DL1*h/*y) lacking alleles expressed at low levels on natural killer cells. We questioned whether this allele combination could also influence resistance to infection.
The genetic distribution of 3DL1*h/*y and HLA-B*57 was compared in 41 HIV-exposed uninfected and 186 recently HIV-infected 3DL1 hmz.
KIR3DL1 subtyping was performed by sequencing the exons 3, 4, 5, 7-9. The major histocompatibility complex class IB locus was typed by sequence specific oligonucleotide PCR and sequencing to resolve Bw4 and Bw6 alleles and the amino acid present at position 80.
Percentage carriers of HLA-B*57 in HIV-exposed uninfected and individuals in a primary infection cohort was 12.2 and 4.3%, respectively (P = 0.0631), whereas that of 3DL1*h/*y was similar in both populations (P = 0.221). The 3DL1*h/*y-HLA-B*57 combined genotype was more frequent in exposed uninfected individuals (12.2%) than individuals in primary infection (2.7%) (P = 0.019; odds ratio, 5.03; 95% confidence intervals, 1.38-18.3).
Coexpression of 3DL1*h/*y and B*57, which has been associated with a reduced risk of progressing to AIDS in HIV-infected individuals also lowers the risk of HIV infection in exposed uninfected individuals.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18614872</pmid><doi>10.1097/QAD.0b013e3282ffde7e</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | AIDS (London), 2008-07, Vol.22 (12), p.1487-1491 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | AIDS/HIV Alleles Biological and medical sciences Cells, Cultured Gene Frequency Genetic Predisposition to Disease Genotype HIV Infections - genetics HIV Infections - immunology HIV-1 HLA-B Antigens - genetics Human immunodeficiency virus Human viral diseases Humans Immunity, Innate - genetics Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Receptors, KIR3DL1 - genetics Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | A combined genotype of KIR3DL1 high expressing alleles and HLA-B57 is associated with a reduced risk of HIV infection |
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