Deconstructing Export of Malaria Proteins

Deconstructing Export of Malaria Proteins

The virulence of the malaria parasite Plasmodium falciparum is mediated by parasite proteins exported to the surface of infected erythrocytes. In this issue, Maier et al. (2008) report a screen of malaria parasite genes predicted to be involved in parasite protein export and trafficking within the h...

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Veröffentlicht in:Cell 2008-07, Vol.134 (1), p.20-22
Hauptverfasser: Bonnefoy, Serge, Ménard, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Erythrocyte Membrane - chemistry
Erythrocytes - cytology
Erythrocytes - parasitology
Humans
Malaria
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - pathogenicity
Protein Transport
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Virulence
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Beschreibung
Zusammenfassung:The virulence of the malaria parasite Plasmodium falciparum is mediated by parasite proteins exported to the surface of infected erythrocytes. In this issue, Maier et al. (2008) report a screen of malaria parasite genes predicted to be involved in parasite protein export and trafficking within the host erythrocyte and discover that many more than expected are essential for parasite survival in vitro.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.06.040