Induction of Globin Synthesis in K562 Cells Is Associated with Differential Expression of Transcription Factor Genes

Globin gene switching may be mediated by proteins expressed during different stages of development. Their identification may clarify the mechanisms of the conversion from fetal to adult globin production and lead to new approaches to reversing or retarding the γ- to β-globin gene switch. To explore...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 1999-06, Vol.25 (3), p.156-165
Hauptverfasser:	Plonczynski, Maria, Hardy, Cheryl L, Safaya, Surinder, Harrell, Audrey, McCoy, Lakeyra, Brinson, Alisha, Agwarangbo, Lovell, Steinberg, Martin H
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Northern DNA, Complementary - analysis DNA, Complementary - chemistry Fetal Hemoglobin - genetics Gene Expression Regulation gene transcription, fetal hemoglobin, γ,-globin gene, differential display PCR, sickle cell anemia Genes, Switch Globins - biosynthesis Globins - genetics Humans K562 Cells Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - pathology Polymerase Chain Reaction Promoter Regions, Genetic - genetics Sequence Analysis, DNA Sequence Analysis, RNA Transcription Factors - genetics
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