Recurrent nodule on the nasal columella: a good reason to re-biopsy
Background A 15‐year‐old Caucasian male presented with 9‐month history of a recurrent nodule on the nasal columella. The previous biopsy was reported as a neurofibroma. Methods Frozen sections revealed a spindle cell neoplasm. Permanent section immunohistochemistry sections stained positive for vi...
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| Veröffentlicht in: | International journal of dermatology 2008-07, Vol.47 (7), p.728-731 |
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| creator | Vujevich, Justin J. Goldberg, Leonard H. Kimyai-Asadi, Arash Law, Robert |
| description | Background A 15‐year‐old Caucasian male presented with 9‐month history of a recurrent nodule on the nasal columella. The previous biopsy was reported as a neurofibroma.
Methods Frozen sections revealed a spindle cell neoplasm. Permanent section immunohistochemistry sections stained positive for vimentin and smooth muscle actin and negative for S100 and CD34, confirming the diagnosis of leiomyosarcoma.
Results The tumor was removed using Mohs micrographic surgery. Radiological work‐up revealed no distant metastasis. There has been no local recurrence to date.
Conclusions Leiomyosarcoma is a difficult diagnosis to make clinically and requires histological confirmation. Re‐biopsy of a “benign” growth may be necessary if clinicopathological correlation does not match with the clinical behavior of the tumor in question. Finally, Mohs micrographic surgery is a useful treatment modality for leiomyosarcomas, particularly those located in cosmetically‐sensitive regions of the body such as the nose. |
| doi_str_mv | 10.1111/j.1365-4632.2008.03536.x |
| format | Article |
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Methods Frozen sections revealed a spindle cell neoplasm. Permanent section immunohistochemistry sections stained positive for vimentin and smooth muscle actin and negative for S100 and CD34, confirming the diagnosis of leiomyosarcoma.
Results The tumor was removed using Mohs micrographic surgery. Radiological work‐up revealed no distant metastasis. There has been no local recurrence to date.
Conclusions Leiomyosarcoma is a difficult diagnosis to make clinically and requires histological confirmation. Re‐biopsy of a “benign” growth may be necessary if clinicopathological correlation does not match with the clinical behavior of the tumor in question. Finally, Mohs micrographic surgery is a useful treatment modality for leiomyosarcomas, particularly those located in cosmetically‐sensitive regions of the body such as the nose.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2008.03536.x</identifier><identifier>PMID: 18613884</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Biopsy, Needle ; Dermatology ; Diagnosis, Differential ; Follow-Up Studies ; Frozen Sections ; Humans ; Immunohistochemistry ; Leiomyosarcoma - diagnosis ; Leiomyosarcoma - pathology ; Leiomyosarcoma - surgery ; Male ; Medical sciences ; Mohs Surgery - methods ; Nasal Septum - pathology ; Nasal Septum - surgery ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neurofibroma - diagnosis ; Neurofibroma - pathology ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Treatment Outcome</subject><ispartof>International journal of dermatology, 2008-07, Vol.47 (7), p.728-731</ispartof><rights>2008 The International Society of Dermatology</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4856-9d8a1bdcecaaeccbcaceabfe4c98e30d1d25b32b6d98744a0cdcee2181082d103</citedby><cites>FETCH-LOGICAL-c4856-9d8a1bdcecaaeccbcaceabfe4c98e30d1d25b32b6d98744a0cdcee2181082d103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4632.2008.03536.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4632.2008.03536.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20453908$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18613884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vujevich, Justin J.</creatorcontrib><creatorcontrib>Goldberg, Leonard H.</creatorcontrib><creatorcontrib>Kimyai-Asadi, Arash</creatorcontrib><creatorcontrib>Law, Robert</creatorcontrib><title>Recurrent nodule on the nasal columella: a good reason to re-biopsy</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background A 15‐year‐old Caucasian male presented with 9‐month history of a recurrent nodule on the nasal columella. The previous biopsy was reported as a neurofibroma.
Methods Frozen sections revealed a spindle cell neoplasm. Permanent section immunohistochemistry sections stained positive for vimentin and smooth muscle actin and negative for S100 and CD34, confirming the diagnosis of leiomyosarcoma.
Results The tumor was removed using Mohs micrographic surgery. Radiological work‐up revealed no distant metastasis. There has been no local recurrence to date.
Conclusions Leiomyosarcoma is a difficult diagnosis to make clinically and requires histological confirmation. Re‐biopsy of a “benign” growth may be necessary if clinicopathological correlation does not match with the clinical behavior of the tumor in question. Finally, Mohs micrographic surgery is a useful treatment modality for leiomyosarcomas, particularly those located in cosmetically‐sensitive regions of the body such as the nose.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Dermatology</subject><subject>Diagnosis, Differential</subject><subject>Follow-Up Studies</subject><subject>Frozen Sections</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leiomyosarcoma - diagnosis</subject><subject>Leiomyosarcoma - pathology</subject><subject>Leiomyosarcoma - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mohs Surgery - methods</subject><subject>Nasal Septum - pathology</subject><subject>Nasal Septum - surgery</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neurofibroma - diagnosis</subject><subject>Neurofibroma - pathology</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Treatment Outcome</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1P2zAUhi0EGgX2F5Bvxl0yf8V1kHYxdVsBIZAQCO6sE_t0S0njYjda--9J1qq7xTc-lp_XfvUQQjnLeb--znMudZEpLUUuGDM5k4XU-fqAjPYXh2TEGOdZyYrymJykNO-PUnD1iRxzo7k0Ro3I5AFdFyO2K9oG3zVIQ0tXf5C2kKChLjTdApsGLinQ3yF4GhHSgIR-yqo6LNPmjBzNoEn4ebefkqdfPx8nV9nt_fR68v02c8oUOiu9AV55hw4AnascOIRqhsqVBiXz3IuikqLSvjRjpYC5nkXBDWdGeM7kKbnYvruM4a3DtLKLOrmhXYuhS1aXkimhTQ-aLehiSCnizC5jvYC4sZzZQaCd28GTHTzZQaD9J9Cu--j57o-uWqD_H9wZ64EvOwCSg2YWoXV12nOCqUKWbOjwbcv9rRvcfLiAvb75MUx9Ptvm67TC9T4P8dXqsRwX9vluassX8zi9KpTV8h3xapt1</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Vujevich, Justin J.</creator><creator>Goldberg, Leonard H.</creator><creator>Kimyai-Asadi, Arash</creator><creator>Law, Robert</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Recurrent nodule on the nasal columella: a good reason to re-biopsy</title><author>Vujevich, Justin J. ; Goldberg, Leonard H. ; Kimyai-Asadi, Arash ; Law, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4856-9d8a1bdcecaaeccbcaceabfe4c98e30d1d25b32b6d98744a0cdcee2181082d103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Dermatology</topic><topic>Diagnosis, Differential</topic><topic>Follow-Up Studies</topic><topic>Frozen Sections</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leiomyosarcoma - diagnosis</topic><topic>Leiomyosarcoma - pathology</topic><topic>Leiomyosarcoma - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mohs Surgery - methods</topic><topic>Nasal Septum - pathology</topic><topic>Nasal Septum - surgery</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neurofibroma - diagnosis</topic><topic>Neurofibroma - pathology</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vujevich, Justin J.</creatorcontrib><creatorcontrib>Goldberg, Leonard H.</creatorcontrib><creatorcontrib>Kimyai-Asadi, Arash</creatorcontrib><creatorcontrib>Law, Robert</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vujevich, Justin J.</au><au>Goldberg, Leonard H.</au><au>Kimyai-Asadi, Arash</au><au>Law, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent nodule on the nasal columella: a good reason to re-biopsy</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>47</volume><issue>7</issue><spage>728</spage><epage>731</epage><pages>728-731</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background A 15‐year‐old Caucasian male presented with 9‐month history of a recurrent nodule on the nasal columella. The previous biopsy was reported as a neurofibroma.
Methods Frozen sections revealed a spindle cell neoplasm. Permanent section immunohistochemistry sections stained positive for vimentin and smooth muscle actin and negative for S100 and CD34, confirming the diagnosis of leiomyosarcoma.
Results The tumor was removed using Mohs micrographic surgery. Radiological work‐up revealed no distant metastasis. There has been no local recurrence to date.
Conclusions Leiomyosarcoma is a difficult diagnosis to make clinically and requires histological confirmation. Re‐biopsy of a “benign” growth may be necessary if clinicopathological correlation does not match with the clinical behavior of the tumor in question. Finally, Mohs micrographic surgery is a useful treatment modality for leiomyosarcomas, particularly those located in cosmetically‐sensitive regions of the body such as the nose.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18613884</pmid><doi>10.1111/j.1365-4632.2008.03536.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biopsy, Needle Dermatology Diagnosis, Differential Follow-Up Studies Frozen Sections Humans Immunohistochemistry Leiomyosarcoma - diagnosis Leiomyosarcoma - pathology Leiomyosarcoma - surgery Male Medical sciences Mohs Surgery - methods Nasal Septum - pathology Nasal Septum - surgery Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neurofibroma - diagnosis Neurofibroma - pathology Skin Neoplasms - diagnosis Skin Neoplasms - pathology Treatment Outcome |
| title | Recurrent nodule on the nasal columella: a good reason to re-biopsy |
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