RBC NOS: regulatory mechanisms and therapeutic aspects
Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l -arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood c...
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| Veröffentlicht in: | Trends in molecular medicine 2008-07, Vol.14 (7), p.314-322 |
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| creator | Özüyaman, Burcin Grau, Marijke Kelm, Malte Merx, Marc W Kleinbongard, Petra |
| description | Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l -arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed. |
| doi_str_mv | 10.1016/j.molmed.2008.05.002 |
| format | Article |
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Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. 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Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed.</description><subject>Animals</subject><subject>Erythrocytes - enzymology</subject><subject>Erythrocytes - metabolism</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type III - metabolism</subject><subject>Pathology</subject><issn>1471-4914</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMo3t9ApCt3U89p0psLQQdvIAqOgruQpqdOxl7GpBXm7U2ZwYUbVwnkO_8h38_YCUKIgMn5Imy6uqEyjACyEOIQINpi-yhSnIg8f9_-vaPYYwfOLQAwTtNsl-1hFvM85rDPkpfrafD0PLsILH0Mteo7uwoa0nPVGte4QLVl0M_JqiUNvdGBckvSvTtiO5WqHR1vzkP2dnvzOr2fPD7fPUyvHidaZNj73UJjXvFcqbSK00qQjihKMdMFRYojRQlHj0ASR56goqASsqTAooKqyoEfsrN17tJ2XwO5XjbGaapr1VI3OJnkHHgs0INiDWrbOWepkktrGmVXEkGOvuRCrn3J0ZeEWHpffux0kz8U49vv0EaQBy7XAPlffhuy0mlDrabSWC9Clp35b8PfAF2b1mhVf9KK3KIbbOsNSpQukiBnY2djZZD5ujAT_AegW5IG</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Özüyaman, Burcin</creator><creator>Grau, Marijke</creator><creator>Kelm, Malte</creator><creator>Merx, Marc W</creator><creator>Kleinbongard, Petra</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>RBC NOS: regulatory mechanisms and therapeutic aspects</title><author>Özüyaman, Burcin ; Grau, Marijke ; Kelm, Malte ; Merx, Marc W ; Kleinbongard, Petra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-494c19f39aa7f57f4ec2e2718cbe2a31e26314c10652a7febbed086b1bf0ff903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Erythrocytes - enzymology</topic><topic>Erythrocytes - metabolism</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type III - metabolism</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özüyaman, Burcin</creatorcontrib><creatorcontrib>Grau, Marijke</creatorcontrib><creatorcontrib>Kelm, Malte</creatorcontrib><creatorcontrib>Merx, Marc W</creatorcontrib><creatorcontrib>Kleinbongard, Petra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özüyaman, Burcin</au><au>Grau, Marijke</au><au>Kelm, Malte</au><au>Merx, Marc W</au><au>Kleinbongard, Petra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RBC NOS: regulatory mechanisms and therapeutic aspects</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>14</volume><issue>7</issue><spage>314</spage><epage>322</epage><pages>314-322</pages><issn>1471-4914</issn><eissn>1471-499X</eissn><abstract>Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l -arginine, cofactors and diverse interacting proteins. 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| subjects | Animals Erythrocytes - enzymology Erythrocytes - metabolism Humans Models, Biological Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III - metabolism Pathology |
| title | RBC NOS: regulatory mechanisms and therapeutic aspects |
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