CYP2C19 genotype–related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori

Objectives Omeprazole is used for the treatment of infection caused by Helicobacter pylori, and it is metabolized by the polymorphic cytochrome P4502C19 (CYP2C19). We have found that the anti–H pylori efficacy by the combination of omeprazole and antibiotics is related to the CYP2C19 genotype. Metho...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 1999-11, Vol.66 (5), p.528-534
Hauptverfasser:	Tanigawara, Yusuke, Aoyama, Nobuo, Kita, Tomoko, Shirakawa, Katsuro, Komada, Fusao, Kasuga, Masato, Okumura, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin - therapeutic use Antacids - therapeutic use Anti-Bacterial Agents - therapeutic use Anti-Ulcer Agents - pharmacology Aryl Hydrocarbon Hydroxylases Biological and medical sciences Bismuth - therapeutic use Clarithromycin - therapeutic use Cytochrome P-450 CYP2C19 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Digestive system Drug Therapy, Combination Enzyme Inhibitors - pharmacology Gastritis - drug therapy Gastritis - microbiology Genotype Helicobacter Infections - drug therapy Helicobacter Infections - microbiology Helicobacter pylori - drug effects Histamine H2 Antagonists - therapeutic use Humans Medical sciences Metronidazole - therapeutic use Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - genetics Omeprazole - pharmacology Penicillins - therapeutic use Peptic Ulcer - drug therapy Peptic Ulcer - microbiology Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Protein Synthesis Inhibitors - therapeutic use Treatment Outcome
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