Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension
Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension. Experimental studies have shown that nitric oxide (NO) generation in the kidney from L-arginine participates in the regulation of renal function. Our purpose was to study the effect of infusion...
Gespeichert in:
| Veröffentlicht in: | Kidney international 1999-11, Vol.56 (5), p.1838-1845 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1845 |
|---|---|
| container_issue | 5 |
| container_start_page | 1838 |
| container_title | Kidney international |
| container_volume | 56 |
| creator | Herlitz, Hans Jungersten, Lennart U. Wikstrand, John Widgren, Bengt R. |
| description | Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension.
Experimental studies have shown that nitric oxide (NO) generation in the kidney from L-arginine participates in the regulation of renal function. Our purpose was to study the effect of infusion of L-arginine (1, 5, and 10 mg/kg/min) on blood pressure (BP), renal hemodynamics, and urinary excretion of sodium and albumin in normotensive subjects with a family history of either severe hypertension (FHSH, N = 17) or mild hypertension (FHMH, N = 20) and in control subjects (N = 18) without a hereditary predisposition for hypertension.
The glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by renal clearances of Cr51 ethylenediaminetetraacetic acid and paramino-hippurate. Renal tubular reabsorption of sodium was estimated by lithium clearance. To evaluate the effect of L-arginine infusion on the L-arginine/NO pathway, we measured the NO-metabolite nitrate in plasma, and urinary excretion of cGMP, the second messenger of NO. The derivative at an L-arginine dose of 7.5 mg/kg/min was used as a measure of sensitivity to L-arginine.
There was no difference in baseline systolic BP between the groups, but diastolic BP was significantly higher in FHSH compared with control subjects (P < 0.05). L-arginine caused a significant increase in urine flow, urinary excretion of albumin and sodium, and lithium clearance in all groups. FHSH showed a significantly decreased sensitivity to L-arginine with respect to urine flow rate (P = 0029) compared with FHMH and control subjects. L-arginine caused a significant decrease in the GFR in FHSH (P < 0.02) and control subjects (P < 0.001), but in FHMH, the decrease did not reach statistical significance (P = 0.097). There was no difference in sensitivity to L-arginine with respect to BP, RPF, or GFR between the three groups. In all patients, there was a significant positive relationship between βDgr; urine flow rate or βDgr; urinary sodium excretion and βDgr; GFR during infusion of L-arginine (P = 0.003 and P = 0.03, respectively). Plasma nitrate and urinary cGMP decreased in all groups during the L-arginine infusion.
L-Arginine infusion in normotensive subjects caused an enhanced urine flow rate and urinary sodium and albumin excretion and a slight reduction in GFR. The effect of L-arginine on the urine flow rate was significantly less pronounced in subjects with a family history of severe hypertension, whic |
| doi_str_mv | 10.1046/j.1523-1755.1999.00735.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69300773</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815465020</els_id><sourcerecordid>69300773</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-7695bee2ea6fd473c35fcf240aae2b588a0b4c02e23dd460d76fbdc5de88f25c3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERZe2fwH5gLgl-COOkyNU5UNaiQs9W449Zr1K7MVOSvff4-yugBsnjzXPOzN6EMKU1JQ07ft9TQXjFZVC1LTv-5oQyUX9_AJt_jReog0hnaiY4N01ep3znpR_z8krdE2JkFT2bIN2D86BmXF0eFvp9MMHHwD74JbsYygFDjFNcYaQ_RPgvAz7gmf8y887rIM9FXGZscZOT3484p3Pc0zHdeLueIB0isZwi66cHjPcXd4b9Pjp4fv9l2r77fPX-w_byjRNP1ey7cUAwEC3zjaSGy6ccawhWgMbRNdpMjSGMGDc2qYlVrZusEZY6DrHhOE36N157iHFnwvkWU0-GxhHHSAuWbXFAJGSF7A7gybFnBM4dUh-0umoKFGrZbVXq0y1ylSrZXWyrJ5L9M1lxzJMYP8JnrUW4O0F0Nno0SUdjM9_Odox1smCfTxjUIQ8eUgqGw_BgPWpWFY2-v8f8xsTFp36</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69300773</pqid></control><display><type>article</type><title>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Herlitz, Hans ; Jungersten, Lennart U. ; Wikstrand, John ; Widgren, Bengt R.</creator><creatorcontrib>Herlitz, Hans ; Jungersten, Lennart U. ; Wikstrand, John ; Widgren, Bengt R.</creatorcontrib><description>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension.
Experimental studies have shown that nitric oxide (NO) generation in the kidney from L-arginine participates in the regulation of renal function. Our purpose was to study the effect of infusion of L-arginine (1, 5, and 10 mg/kg/min) on blood pressure (BP), renal hemodynamics, and urinary excretion of sodium and albumin in normotensive subjects with a family history of either severe hypertension (FHSH, N = 17) or mild hypertension (FHMH, N = 20) and in control subjects (N = 18) without a hereditary predisposition for hypertension.
The glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by renal clearances of Cr51 ethylenediaminetetraacetic acid and paramino-hippurate. Renal tubular reabsorption of sodium was estimated by lithium clearance. To evaluate the effect of L-arginine infusion on the L-arginine/NO pathway, we measured the NO-metabolite nitrate in plasma, and urinary excretion of cGMP, the second messenger of NO. The derivative at an L-arginine dose of 7.5 mg/kg/min was used as a measure of sensitivity to L-arginine.
There was no difference in baseline systolic BP between the groups, but diastolic BP was significantly higher in FHSH compared with control subjects (P < 0.05). L-arginine caused a significant increase in urine flow, urinary excretion of albumin and sodium, and lithium clearance in all groups. FHSH showed a significantly decreased sensitivity to L-arginine with respect to urine flow rate (P = 0029) compared with FHMH and control subjects. L-arginine caused a significant decrease in the GFR in FHSH (P < 0.02) and control subjects (P < 0.001), but in FHMH, the decrease did not reach statistical significance (P = 0.097). There was no difference in sensitivity to L-arginine with respect to BP, RPF, or GFR between the three groups. In all patients, there was a significant positive relationship between βDgr; urine flow rate or βDgr; urinary sodium excretion and βDgr; GFR during infusion of L-arginine (P = 0.003 and P = 0.03, respectively). Plasma nitrate and urinary cGMP decreased in all groups during the L-arginine infusion.
L-Arginine infusion in normotensive subjects caused an enhanced urine flow rate and urinary sodium and albumin excretion and a slight reduction in GFR. The effect of L-arginine on the urine flow rate was significantly less pronounced in subjects with a family history of severe hypertension, which may indicate a tubular disturbance in hypertension.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1046/j.1523-1755.1999.00735.x</identifier><identifier>PMID: 10571792</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Arginine - pharmacology ; Biological and medical sciences ; familial hypertension ; Fundamental and applied biological sciences. Psychology ; Glomerular Filtration Rate - drug effects ; high blood pressure ; Humans ; Hypertension - genetics ; Hypertension - physiopathology ; Kidney - drug effects ; Kidney - physiology ; Male ; nitric oxide ; Nitric Oxide - physiology ; Renal Circulation - drug effects ; renal hemodynamics ; Renin - blood ; Sodium - metabolism ; sodium excretion ; Vertebrates: urinary system</subject><ispartof>Kidney international, 1999-11, Vol.56 (5), p.1838-1845</ispartof><rights>1999 International Society of Nephrology</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-7695bee2ea6fd473c35fcf240aae2b588a0b4c02e23dd460d76fbdc5de88f25c3</citedby><cites>FETCH-LOGICAL-c449t-7695bee2ea6fd473c35fcf240aae2b588a0b4c02e23dd460d76fbdc5de88f25c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1182287$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10571792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herlitz, Hans</creatorcontrib><creatorcontrib>Jungersten, Lennart U.</creatorcontrib><creatorcontrib>Wikstrand, John</creatorcontrib><creatorcontrib>Widgren, Bengt R.</creatorcontrib><title>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension.
Experimental studies have shown that nitric oxide (NO) generation in the kidney from L-arginine participates in the regulation of renal function. Our purpose was to study the effect of infusion of L-arginine (1, 5, and 10 mg/kg/min) on blood pressure (BP), renal hemodynamics, and urinary excretion of sodium and albumin in normotensive subjects with a family history of either severe hypertension (FHSH, N = 17) or mild hypertension (FHMH, N = 20) and in control subjects (N = 18) without a hereditary predisposition for hypertension.
The glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by renal clearances of Cr51 ethylenediaminetetraacetic acid and paramino-hippurate. Renal tubular reabsorption of sodium was estimated by lithium clearance. To evaluate the effect of L-arginine infusion on the L-arginine/NO pathway, we measured the NO-metabolite nitrate in plasma, and urinary excretion of cGMP, the second messenger of NO. The derivative at an L-arginine dose of 7.5 mg/kg/min was used as a measure of sensitivity to L-arginine.
There was no difference in baseline systolic BP between the groups, but diastolic BP was significantly higher in FHSH compared with control subjects (P < 0.05). L-arginine caused a significant increase in urine flow, urinary excretion of albumin and sodium, and lithium clearance in all groups. FHSH showed a significantly decreased sensitivity to L-arginine with respect to urine flow rate (P = 0029) compared with FHMH and control subjects. L-arginine caused a significant decrease in the GFR in FHSH (P < 0.02) and control subjects (P < 0.001), but in FHMH, the decrease did not reach statistical significance (P = 0.097). There was no difference in sensitivity to L-arginine with respect to BP, RPF, or GFR between the three groups. In all patients, there was a significant positive relationship between βDgr; urine flow rate or βDgr; urinary sodium excretion and βDgr; GFR during infusion of L-arginine (P = 0.003 and P = 0.03, respectively). Plasma nitrate and urinary cGMP decreased in all groups during the L-arginine infusion.
L-Arginine infusion in normotensive subjects caused an enhanced urine flow rate and urinary sodium and albumin excretion and a slight reduction in GFR. The effect of L-arginine on the urine flow rate was significantly less pronounced in subjects with a family history of severe hypertension, which may indicate a tubular disturbance in hypertension.</description><subject>Adult</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>familial hypertension</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>high blood pressure</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Renal Circulation - drug effects</subject><subject>renal hemodynamics</subject><subject>Renin - blood</subject><subject>Sodium - metabolism</subject><subject>sodium excretion</subject><subject>Vertebrates: urinary system</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZe2fwH5gLgl-COOkyNU5UNaiQs9W449Zr1K7MVOSvff4-yugBsnjzXPOzN6EMKU1JQ07ft9TQXjFZVC1LTv-5oQyUX9_AJt_jReog0hnaiY4N01ep3znpR_z8krdE2JkFT2bIN2D86BmXF0eFvp9MMHHwD74JbsYygFDjFNcYaQ_RPgvAz7gmf8y887rIM9FXGZscZOT3484p3Pc0zHdeLueIB0isZwi66cHjPcXd4b9Pjp4fv9l2r77fPX-w_byjRNP1ey7cUAwEC3zjaSGy6ccawhWgMbRNdpMjSGMGDc2qYlVrZusEZY6DrHhOE36N157iHFnwvkWU0-GxhHHSAuWbXFAJGSF7A7gybFnBM4dUh-0umoKFGrZbVXq0y1ylSrZXWyrJ5L9M1lxzJMYP8JnrUW4O0F0Nno0SUdjM9_Odox1smCfTxjUIQ8eUgqGw_BgPWpWFY2-v8f8xsTFp36</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Herlitz, Hans</creator><creator>Jungersten, Lennart U.</creator><creator>Wikstrand, John</creator><creator>Widgren, Bengt R.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension</title><author>Herlitz, Hans ; Jungersten, Lennart U. ; Wikstrand, John ; Widgren, Bengt R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-7695bee2ea6fd473c35fcf240aae2b588a0b4c02e23dd460d76fbdc5de88f25c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>familial hypertension</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>high blood pressure</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Male</topic><topic>nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Renal Circulation - drug effects</topic><topic>renal hemodynamics</topic><topic>Renin - blood</topic><topic>Sodium - metabolism</topic><topic>sodium excretion</topic><topic>Vertebrates: urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herlitz, Hans</creatorcontrib><creatorcontrib>Jungersten, Lennart U.</creatorcontrib><creatorcontrib>Wikstrand, John</creatorcontrib><creatorcontrib>Widgren, Bengt R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herlitz, Hans</au><au>Jungersten, Lennart U.</au><au>Wikstrand, John</au><au>Widgren, Bengt R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>56</volume><issue>5</issue><spage>1838</spage><epage>1845</epage><pages>1838-1845</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension.
Experimental studies have shown that nitric oxide (NO) generation in the kidney from L-arginine participates in the regulation of renal function. Our purpose was to study the effect of infusion of L-arginine (1, 5, and 10 mg/kg/min) on blood pressure (BP), renal hemodynamics, and urinary excretion of sodium and albumin in normotensive subjects with a family history of either severe hypertension (FHSH, N = 17) or mild hypertension (FHMH, N = 20) and in control subjects (N = 18) without a hereditary predisposition for hypertension.
The glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by renal clearances of Cr51 ethylenediaminetetraacetic acid and paramino-hippurate. Renal tubular reabsorption of sodium was estimated by lithium clearance. To evaluate the effect of L-arginine infusion on the L-arginine/NO pathway, we measured the NO-metabolite nitrate in plasma, and urinary excretion of cGMP, the second messenger of NO. The derivative at an L-arginine dose of 7.5 mg/kg/min was used as a measure of sensitivity to L-arginine.
There was no difference in baseline systolic BP between the groups, but diastolic BP was significantly higher in FHSH compared with control subjects (P < 0.05). L-arginine caused a significant increase in urine flow, urinary excretion of albumin and sodium, and lithium clearance in all groups. FHSH showed a significantly decreased sensitivity to L-arginine with respect to urine flow rate (P = 0029) compared with FHMH and control subjects. L-arginine caused a significant decrease in the GFR in FHSH (P < 0.02) and control subjects (P < 0.001), but in FHMH, the decrease did not reach statistical significance (P = 0.097). There was no difference in sensitivity to L-arginine with respect to BP, RPF, or GFR between the three groups. In all patients, there was a significant positive relationship between βDgr; urine flow rate or βDgr; urinary sodium excretion and βDgr; GFR during infusion of L-arginine (P = 0.003 and P = 0.03, respectively). Plasma nitrate and urinary cGMP decreased in all groups during the L-arginine infusion.
L-Arginine infusion in normotensive subjects caused an enhanced urine flow rate and urinary sodium and albumin excretion and a slight reduction in GFR. The effect of L-arginine on the urine flow rate was significantly less pronounced in subjects with a family history of severe hypertension, which may indicate a tubular disturbance in hypertension.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10571792</pmid><doi>10.1046/j.1523-1755.1999.00735.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 1999-11, Vol.56 (5), p.1838-1845 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69300773 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Arginine - pharmacology Biological and medical sciences familial hypertension Fundamental and applied biological sciences. Psychology Glomerular Filtration Rate - drug effects high blood pressure Humans Hypertension - genetics Hypertension - physiopathology Kidney - drug effects Kidney - physiology Male nitric oxide Nitric Oxide - physiology Renal Circulation - drug effects renal hemodynamics Renin - blood Sodium - metabolism sodium excretion Vertebrates: urinary system |
| title | Effect of L-arginine infusion in normotensive subjects with and without a family history of hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T11%3A09%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20L-arginine%20infusion%20in%20normotensive%20subjects%20with%20and%20without%20a%20family%20history%20of%20hypertension&rft.jtitle=Kidney%20international&rft.au=Herlitz,%20Hans&rft.date=1999-11-01&rft.volume=56&rft.issue=5&rft.spage=1838&rft.epage=1845&rft.pages=1838-1845&rft.issn=0085-2538&rft.eissn=1523-1755&rft.coden=KDYIA5&rft_id=info:doi/10.1046/j.1523-1755.1999.00735.x&rft_dat=%3Cproquest_cross%3E69300773%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69300773&rft_id=info:pmid/10571792&rft_els_id=S0085253815465020&rfr_iscdi=true |