Further hypotensive metabolites from verbesina caracasana
After the isolation of caracasanamide and caracasandiamide, further hypotensive components of Verbesina caracasana were shown to be N 3-prenylagmatine, N 1-3′,4′-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1999-11, Vol.9 (22), p.3249-3254 |
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| creator | Monache, Giuliano Delle Volpe, Anna Rita Monache, Franco Delle Vitali, Alberto Botta, Bruno Espinal, Romulo De Bonnevaux, Stella C. Luca, Carlo De Botta, Maurizio Corelli, Federico Carmignani, Marco |
| description | After the isolation of caracasanamide and caracasandiamide, further hypotensive components of
Verbesina caracasana were shown to be N
3-prenylagmatine, N
1-3′,4′-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both metabolites and products from their alkaline hydrolyses. A pharmacological analysis of these products is also presented.
The new guanidino derivatives G3 and G5 were isolated from Verbesina caracasana together with agmatine (G6) and galegine (G7). The anti-hypertensive activity of these compounds, compared with various vasodilating drugs, is also discussed. |
| doi_str_mv | 10.1016/S0960-894X(99)00569-7 |
| format | Article |
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Verbesina caracasana were shown to be N
3-prenylagmatine, N
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The new guanidino derivatives G3 and G5 were isolated from Verbesina caracasana together with agmatine (G6) and galegine (G7). The anti-hypertensive activity of these compounds, compared with various vasodilating drugs, is also discussed.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(99)00569-7</identifier><identifier>PMID: 10576697</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; antihypertension ; Antihypertensive Agents - chemistry ; Antihypertensive Agents - isolation & purification ; Asteraceae - chemistry ; Biological and medical sciences ; cardiovascular activity ; General pharmacology ; Mass Spectrometry ; Medical sciences ; Natural products ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Rats ; vasodilators</subject><ispartof>Bioorganic & medicinal chemistry letters, 1999-11, Vol.9 (22), p.3249-3254</ispartof><rights>1999</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-6679bc1fa14121b0263221e22a554baffa57429e1a5b03a08e49d84cd286e3963</citedby><cites>FETCH-LOGICAL-c390t-6679bc1fa14121b0263221e22a554baffa57429e1a5b03a08e49d84cd286e3963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-894X(99)00569-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1213864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10576697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monache, Giuliano Delle</creatorcontrib><creatorcontrib>Volpe, Anna Rita</creatorcontrib><creatorcontrib>Monache, Franco Delle</creatorcontrib><creatorcontrib>Vitali, Alberto</creatorcontrib><creatorcontrib>Botta, Bruno</creatorcontrib><creatorcontrib>Espinal, Romulo</creatorcontrib><creatorcontrib>De Bonnevaux, Stella C.</creatorcontrib><creatorcontrib>Luca, Carlo De</creatorcontrib><creatorcontrib>Botta, Maurizio</creatorcontrib><creatorcontrib>Corelli, Federico</creatorcontrib><creatorcontrib>Carmignani, Marco</creatorcontrib><title>Further hypotensive metabolites from verbesina caracasana</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>After the isolation of caracasanamide and caracasandiamide, further hypotensive components of
Verbesina caracasana were shown to be N
3-prenylagmatine, N
1-3′,4′-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both metabolites and products from their alkaline hydrolyses. A pharmacological analysis of these products is also presented.
The new guanidino derivatives G3 and G5 were isolated from Verbesina caracasana together with agmatine (G6) and galegine (G7). The anti-hypertensive activity of these compounds, compared with various vasodilating drugs, is also discussed.</description><subject>Animals</subject><subject>antihypertension</subject><subject>Antihypertensive Agents - chemistry</subject><subject>Antihypertensive Agents - isolation & purification</subject><subject>Asteraceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>cardiovascular activity</subject><subject>General pharmacology</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Natural products</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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1-3′,4′-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both metabolites and products from their alkaline hydrolyses. A pharmacological analysis of these products is also presented.
The new guanidino derivatives G3 and G5 were isolated from Verbesina caracasana together with agmatine (G6) and galegine (G7). The anti-hypertensive activity of these compounds, compared with various vasodilating drugs, is also discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10576697</pmid><doi>10.1016/S0960-894X(99)00569-7</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals antihypertension Antihypertensive Agents - chemistry Antihypertensive Agents - isolation & purification Asteraceae - chemistry Biological and medical sciences cardiovascular activity General pharmacology Mass Spectrometry Medical sciences Natural products Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats vasodilators |
| title | Further hypotensive metabolites from verbesina caracasana |
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