Synthesis, Calcium Channel Antagonist Activity, and Anticonvulsant Activity of 3-Ethyl 5-Methyl 1,4-Dihydro-2-[(2-hydroxyethoxy)methyl]-6-methyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate Coupled to a 1-Methyl-1,4-dihydropyridyl-3-carbonyl Chemical Delivery System

3‐Ethyl 5‐methyl 1,4‐dihydro‐2‐[(2‐hydroxyethoxy)methyl]‐6‐methyl‐4‐(2,3‐dichlorophenyl)‐3,5‐pyridinedicarboxylate (13), a bioisostere of amlodipine, was prepared by the reaction of ethyl 4‐(2‐hydroxyethoxy)acetoacetate (11) with methyl 2‐(2,3‐dichlorobenzylidene) acetoacetate (12) and NH4OAc. Compo...

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