FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
The FTO ( Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS ( n = 207) a...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2008-08, Vol.373 (2), p.230-234 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Attaoua, Redha Ait El Mkadem, Samira Radian, Serban Fica, Simona Hanzu, Felicia Albu, Alice Gheorghiu, Monica Coculescu, Mihai Grigorescu, Florin |
| description | The FTO (
Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (
n
=
207) and controls (
n
=
100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (
P
<
0.0001, OR 3.2, 95% CI 1.8–5.7) and impaired fasting glucose (IFG) with
P
<
0.0007, OR 7.7, 95% CI 2.1–28.6, independently of BMI or age, and to AUC
gluc during OGTT (
P
<
0.0001,
α
=
0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS. |
| doi_str_mv | 10.1016/j.bbrc.2008.06.039 |
| format | Article |
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Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (
n
=
207) and controls (
n
=
100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (
P
<
0.0001, OR 3.2, 95% CI 1.8–5.7) and impaired fasting glucose (IFG) with
P
<
0.0007, OR 7.7, 95% CI 2.1–28.6, independently of BMI or age, and to AUC
gluc during OGTT (
P
<
0.0001,
α
=
0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2008.06.039</identifier><identifier>PMID: 18572014</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Body Mass Index ; Case-Control Studies ; Fasting ; Female ; FTO gene ; Genetic association ; Genotype ; Glucose - metabolism ; Glucose intolerance ; Glucose Intolerance - complications ; Glucose Intolerance - genetics ; Haplotype ; Homozygote ; Humans ; Insulin resistance ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - genetics ; Obesity ; Phenotype ; Polycystic ovary ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Single Nucleotide ; Proteins - genetics ; Single nucleotide polymorphism</subject><ispartof>Biochemical and biophysical research communications, 2008-08, Vol.373 (2), p.230-234</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-e91a219fe18aa8f0defa791d4003c853469be47f1320d2a100672a391b89c2283</citedby><cites>FETCH-LOGICAL-c385t-e91a219fe18aa8f0defa791d4003c853469be47f1320d2a100672a391b89c2283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2008.06.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18572014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attaoua, Redha</creatorcontrib><creatorcontrib>Ait El Mkadem, Samira</creatorcontrib><creatorcontrib>Radian, Serban</creatorcontrib><creatorcontrib>Fica, Simona</creatorcontrib><creatorcontrib>Hanzu, Felicia</creatorcontrib><creatorcontrib>Albu, Alice</creatorcontrib><creatorcontrib>Gheorghiu, Monica</creatorcontrib><creatorcontrib>Coculescu, Mihai</creatorcontrib><creatorcontrib>Grigorescu, Florin</creatorcontrib><title>FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The FTO (
Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (
n
=
207) and controls (
n
=
100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (
P
<
0.0001, OR 3.2, 95% CI 1.8–5.7) and impaired fasting glucose (IFG) with
P
<
0.0007, OR 7.7, 95% CI 2.1–28.6, independently of BMI or age, and to AUC
gluc during OGTT (
P
<
0.0001,
α
=
0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.</description><subject>Adult</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Fasting</subject><subject>Female</subject><subject>FTO gene</subject><subject>Genetic association</subject><subject>Genotype</subject><subject>Glucose - metabolism</subject><subject>Glucose intolerance</subject><subject>Glucose Intolerance - complications</subject><subject>Glucose Intolerance - genetics</subject><subject>Haplotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - genetics</subject><subject>Obesity</subject><subject>Phenotype</subject><subject>Polycystic ovary</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - genetics</subject><subject>Single nucleotide polymorphism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78AQ_Sk7fWmfRjE_Ai4qogiKDgLaTpVLO0zZp0lf33ZtlFb3qZuTzvy8zD2ClChoDVxTyra28yDiAyqDLI5Q6bIEhIOUKxyyYAUKVc4usBOwxhDoBYVHKfHaAopxywmLCn2fNj8kYDJToEZ6weKSSjS3oade06a5KwGhrvekrskHzFHacd35OF61ZmFcZIuE_tVz_cMdtrdRfoZLuP2Mvs5vn6Ln14vL2_vnpITS7KMSWJmqNsCYXWooWGWj2V2BQAuRFlHg-tqZi2mHNouMb4ypTrXGItpOFc5EfsfNO78O5jSWFUvQ2Guk4P5JZBVZJLKWT5Lxj9cVGijCDfgMa7EDy1auFtH39TCGptXM3V2vg6IRRUKhqPobNt-7LuqfmNbBVH4HIDUJTxacmrYCwNhhrryYyqcfav_m_ZSZHE</recordid><startdate>20080822</startdate><enddate>20080822</enddate><creator>Attaoua, Redha</creator><creator>Ait El Mkadem, Samira</creator><creator>Radian, Serban</creator><creator>Fica, Simona</creator><creator>Hanzu, Felicia</creator><creator>Albu, Alice</creator><creator>Gheorghiu, Monica</creator><creator>Coculescu, Mihai</creator><creator>Grigorescu, Florin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080822</creationdate><title>FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome</title><author>Attaoua, Redha ; Ait El Mkadem, Samira ; Radian, Serban ; Fica, Simona ; Hanzu, Felicia ; Albu, Alice ; Gheorghiu, Monica ; Coculescu, Mihai ; Grigorescu, Florin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-e91a219fe18aa8f0defa791d4003c853469be47f1320d2a100672a391b89c2283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Fasting</topic><topic>Female</topic><topic>FTO gene</topic><topic>Genetic association</topic><topic>Genotype</topic><topic>Glucose - metabolism</topic><topic>Glucose intolerance</topic><topic>Glucose Intolerance - complications</topic><topic>Glucose Intolerance - genetics</topic><topic>Haplotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - genetics</topic><topic>Obesity</topic><topic>Phenotype</topic><topic>Polycystic ovary</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - genetics</topic><topic>Single nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Attaoua, Redha</creatorcontrib><creatorcontrib>Ait El Mkadem, Samira</creatorcontrib><creatorcontrib>Radian, Serban</creatorcontrib><creatorcontrib>Fica, Simona</creatorcontrib><creatorcontrib>Hanzu, Felicia</creatorcontrib><creatorcontrib>Albu, Alice</creatorcontrib><creatorcontrib>Gheorghiu, Monica</creatorcontrib><creatorcontrib>Coculescu, Mihai</creatorcontrib><creatorcontrib>Grigorescu, Florin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Attaoua, Redha</au><au>Ait El Mkadem, Samira</au><au>Radian, Serban</au><au>Fica, Simona</au><au>Hanzu, Felicia</au><au>Albu, Alice</au><au>Gheorghiu, Monica</au><au>Coculescu, Mihai</au><au>Grigorescu, Florin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2008-08-22</date><risdate>2008</risdate><volume>373</volume><issue>2</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The FTO (
Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (
n
=
207) and controls (
n
=
100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (
P
<
0.0001, OR 3.2, 95% CI 1.8–5.7) and impaired fasting glucose (IFG) with
P
<
0.0007, OR 7.7, 95% CI 2.1–28.6, independently of BMI or age, and to AUC
gluc during OGTT (
P
<
0.0001,
α
=
0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18572014</pmid><doi>10.1016/j.bbrc.2008.06.039</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO Body Mass Index Case-Control Studies Fasting Female FTO gene Genetic association Genotype Glucose - metabolism Glucose intolerance Glucose Intolerance - complications Glucose Intolerance - genetics Haplotype Homozygote Humans Insulin resistance Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - genetics Obesity Phenotype Polycystic ovary Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - genetics Polymorphism, Single Nucleotide Proteins - genetics Single nucleotide polymorphism |
| title | FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome |
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