Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth
To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including...
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| creator | Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan)) |
| description | To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3mg pyridoxine⋅HCl (PN⋅HCl)/d during pregnancy. Maternal PN⋅HCl supplementations were positively correlat-ed to both maternal (r=0.62) and cord (r=0.78) plasma PLP concentrations (p |
| doi_str_mv | 10.3177/jnsv.45.449 |
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(National Cheng Kung Univ., Tainan (Taiwan))</creator><creatorcontrib>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</creatorcontrib><description>To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3mg pyridoxine⋅HCl (PN⋅HCl)/d during pregnancy. Maternal PN⋅HCl supplementations were positively correlat-ed to both maternal (r=0.62) and cord (r=0.78) plasma PLP concentrations (p<0.0001). Mothers supplemented with 2 or 3mg/d PN⋅HCl had significantly higher plasma concentrations of PLP and total B6 aldehyde vitamer in maternal and cord blood compared with those receiving 0 or 1 mg PN⋅HCl/d. A growth benefit for neonates whose mothers had maternal and cord plasma PLP concentrations≥40nM was revealed by the maternal supplementation of 2mg PN⋅HCl/d during pregnancy. Thus, in healthy pregnant women, according to our study, a daily supplement of 2 mg PN⋅HCl provides the adequacy of maternal and neonatal vitamin B6 status and the satisfactory growth of neonates at birth.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.45.449</identifier><identifier>PMID: 10575635</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>ANIMAL NOUVEAU NE ; ANIMAL RECIEN NACIDO ; B6 vitamers ; BEBES ; Biological and medical sciences ; CRECIMIENTO ; CROISSANCE ; Dietary Supplements ; ENFANT EN BAS AGE ; Feeding. Feeding behavior ; Female ; Fetal Blood - metabolism ; Fundamental and applied biological sciences. Psychology ; GESTACION ; GESTATION ; GROWTH ; Humans ; Infant, Newborn - growth & development ; INFANTS ; neonate ; NEWBORN ANIMALS ; Nutritional Status ; PIRIDOXINA ; PREGNANCY ; Pyridoxal - blood ; Pyridoxal Phosphate - blood ; PYRIDOXINE ; Pyridoxine - administration & dosage ; Pyridoxine - blood ; pyridoxine supplement ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of Nutritional Science and Vitaminology, 1999, Vol.45(4), pp.449-458</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4979-57026175e2ca30a99929245c72b883a4bbb67df7b7c43096670fac00bb0d52193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1194515$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10575635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</creatorcontrib><title>Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3mg pyridoxine⋅HCl (PN⋅HCl)/d during pregnancy. Maternal PN⋅HCl supplementations were positively correlat-ed to both maternal (r=0.62) and cord (r=0.78) plasma PLP concentrations (p<0.0001). Mothers supplemented with 2 or 3mg/d PN⋅HCl had significantly higher plasma concentrations of PLP and total B6 aldehyde vitamer in maternal and cord blood compared with those receiving 0 or 1 mg PN⋅HCl/d. A growth benefit for neonates whose mothers had maternal and cord plasma PLP concentrations≥40nM was revealed by the maternal supplementation of 2mg PN⋅HCl/d during pregnancy. Thus, in healthy pregnant women, according to our study, a daily supplement of 2 mg PN⋅HCl provides the adequacy of maternal and neonatal vitamin B6 status and the satisfactory growth of neonates at birth.</description><subject>ANIMAL NOUVEAU NE</subject><subject>ANIMAL RECIEN NACIDO</subject><subject>B6 vitamers</subject><subject>BEBES</subject><subject>Biological and medical sciences</subject><subject>CRECIMIENTO</subject><subject>CROISSANCE</subject><subject>Dietary Supplements</subject><subject>ENFANT EN BAS AGE</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>GROWTH</subject><subject>Humans</subject><subject>Infant, Newborn - growth & development</subject><subject>INFANTS</subject><subject>neonate</subject><subject>NEWBORN ANIMALS</subject><subject>Nutritional Status</subject><subject>PIRIDOXINA</subject><subject>PREGNANCY</subject><subject>Pyridoxal - blood</subject><subject>Pyridoxal Phosphate - blood</subject><subject>PYRIDOXINE</subject><subject>Pyridoxine - administration & dosage</subject><subject>Pyridoxine - blood</subject><subject>pyridoxine supplement</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1u1DAUhS0EotPCijXIC9QNmsGO7ThelvKvSrCAtXXjOBmPEie1ncI8AO-N04wKXtjSPd89xzoIvaBkx6iUbw8-3u242HGuHqENrSq6lZIXj9GGMEK3vCLkDJ3HeCCEq4pXT9EZJUKKkokN-nPV2NsZzBGPLR4g2eChx9MxuGb87bzFcZ6m3g7WJ0hu9LiZg_MdnoLtPPi85zwOtl_FNOK0t_jOJRjy_F2JY16bIwbf4C6Mv9J-yfF29DkqjxOuXUj7Z-hJC320z0_vBfr58cOP68_bm2-fvlxf3WwNV1JthSRFSaWwhQFGQClVqIILI4u6qhjwuq5L2bSyloYzospSkhYMIXVNGlFQxS7Q5eo7hfF2tjHpwUVj-x7yl-aoy2yoCJMZfLOCJowxBtvqKbgBwlFTopfW9dK65kLn1jP96mQ714Nt_mPXmjPw-gRANNC3ITfn4j-OKi7ogr1fsUOurbMPOoTkTG_vM6mS7D73dHH1IJs9BG19tnm52rQwauhCTvr6vSDLobRQ7C_o0a17</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth</title><author>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4979-57026175e2ca30a99929245c72b883a4bbb67df7b7c43096670fac00bb0d52193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>ANIMAL NOUVEAU NE</topic><topic>ANIMAL RECIEN NACIDO</topic><topic>B6 vitamers</topic><topic>BEBES</topic><topic>Biological and medical sciences</topic><topic>CRECIMIENTO</topic><topic>CROISSANCE</topic><topic>Dietary Supplements</topic><topic>ENFANT EN BAS AGE</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>GROWTH</topic><topic>Humans</topic><topic>Infant, Newborn - growth & development</topic><topic>INFANTS</topic><topic>neonate</topic><topic>NEWBORN ANIMALS</topic><topic>Nutritional Status</topic><topic>PIRIDOXINA</topic><topic>PREGNANCY</topic><topic>Pyridoxal - blood</topic><topic>Pyridoxal Phosphate - blood</topic><topic>PYRIDOXINE</topic><topic>Pyridoxine - administration & dosage</topic><topic>Pyridoxine - blood</topic><topic>pyridoxine supplement</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, S.J. (National Cheng Kung Univ., Tainan (Taiwan))</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>1999</date><risdate>1999</risdate><volume>45</volume><issue>4</issue><spage>449</spage><epage>458</epage><pages>449-458</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3mg pyridoxine⋅HCl (PN⋅HCl)/d during pregnancy. Maternal PN⋅HCl supplementations were positively correlat-ed to both maternal (r=0.62) and cord (r=0.78) plasma PLP concentrations (p<0.0001). Mothers supplemented with 2 or 3mg/d PN⋅HCl had significantly higher plasma concentrations of PLP and total B6 aldehyde vitamer in maternal and cord blood compared with those receiving 0 or 1 mg PN⋅HCl/d. A growth benefit for neonates whose mothers had maternal and cord plasma PLP concentrations≥40nM was revealed by the maternal supplementation of 2mg PN⋅HCl/d during pregnancy. Thus, in healthy pregnant women, according to our study, a daily supplement of 2 mg PN⋅HCl provides the adequacy of maternal and neonatal vitamin B6 status and the satisfactory growth of neonates at birth.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>10575635</pmid><doi>10.3177/jnsv.45.449</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ANIMAL NOUVEAU NE ANIMAL RECIEN NACIDO B6 vitamers BEBES Biological and medical sciences CRECIMIENTO CROISSANCE Dietary Supplements ENFANT EN BAS AGE Feeding. Feeding behavior Female Fetal Blood - metabolism Fundamental and applied biological sciences. Psychology GESTACION GESTATION GROWTH Humans Infant, Newborn - growth & development INFANTS neonate NEWBORN ANIMALS Nutritional Status PIRIDOXINA PREGNANCY Pyridoxal - blood Pyridoxal Phosphate - blood PYRIDOXINE Pyridoxine - administration & dosage Pyridoxine - blood pyridoxine supplement Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth |
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