Kinetics of doxorubicin handling in the LLC-PK1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport

The subcellular distribution of doxorubicin was evaluated in living non-fixed LLC-PK1 cells, which maintain the structural and functional characteristics of the kidney proximal tubule epithelium and also express P-glycoprotein. After 10 min incubation, doxorubicin fluorescence was detectable in the...

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Veröffentlicht in:	Journal of molecular histology 1999-10, Vol.31 (10), p.635-643
Hauptverfasser:	Crivellato, E, Candussio, L, Rosati, A M, Decorti, G, Klugmann, F B, Mallardi, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacokinetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological Transport Blotting, Western Cells Doxorubicin - pharmacokinetics Epithelial Cells Kidney Tubules, Proximal - metabolism LLC-PK1 Cells Microscopy, Fluorescence Proteins Reverse Transcriptase Polymerase Chain Reaction Swine Verapamil - analogs & derivatives Verapamil - metabolism Vinblastine - metabolism
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