Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes

The topoisomerase I inhibitor camptothecin and its analogs have potent activity against a wide range of solid tumors and several hematologic malignancies. Previous studies with these compounds using the MTT metabolic inhibition assay have shown significant cytotoxicity against lymphocytes from patie...

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Veröffentlicht in:	Leukemia research 1999-11, Vol.23 (11), p.1061-1070
Hauptverfasser:	Cohen, Darrel P, Adams, David J, Flowers, James L, Wall, Monroe E, Wani, Mansukh C, Manikumar, G, Colvin, O.Michael, Silber, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences camptothecin Camptothecin - analogs & derivatives Camptothecin - pharmacology Cell Cycle - drug effects Chronic B-cell lymphocytic leukemia DNA topoisomerase inhibitors Drug Screening Assays, Antitumor General aspects Humans Irinotecan Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphocytes - drug effects Medical sciences Nucleic Acid Synthesis Inhibitors - pharmacology Pharmacology. Drug treatments RNA, Neoplasm - biosynthesis Topoisomerase I inhibitors Tumor Cells, Cultured
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