Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis : Evidence for smooth muscle cell-mediated vascular calcification

Calcification of the media of peripheral arteries is referred to as Mönckeberg's sclerosis (MS) and occurs commonly in aged and diabetic individuals. Its pathogenesis is unknown, but its presence predicts risk of cardiovascular events and leg amputation in diabetic patients. Several studies hav...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-11, Vol.100 (21), p.2168-2176
Hauptverfasser:	SHANAHAN, C. M, CARY, N. R. B, SALISBURY, J. R, PROUDFOOT, D, WEISSBERG, P. L, EDMONDS, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Arteries - metabolism Arteries - pathology Biological and medical sciences Blood and lymphatic vessels Bone Morphogenetic Proteins - analysis Bone Morphogenetic Proteins - genetics Calcinosis - metabolism Calcium - metabolism Calcium-Binding Proteins - analysis Calcium-Binding Proteins - genetics Cardiology. Vascular system Cells, Cultured Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Extracellular Matrix Proteins Female Humans Male Matrix Gla Protein Medical sciences Middle Aged Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Osteopontin Sclerosis Sialoglycoproteins - analysis Sialoglycoproteins - genetics
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