Iron as catalyst for oxidative stress in the pathogenesis of Parkinson's disease?

The mechanisms leading to degeneration of melanized dopaminergic neurons in the brain stem, and particularly in the substantia nigra zona compacta (SNZC) in patients with Parkinson's disease (PD) are still unknown. Demonstration of increased iron Fe(III) in SNZC of PD brain has suggested that F...

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Veröffentlicht in:	Life sciences (1973) 1999-10, Vol.65 (18), p.1973-1976
Hauptverfasser:	Kienzl, E., Jellinger, K., Stachelberger, H., Linert, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-hydroxydopamine Aged Aged, 80 and over Brain - metabolism Brain - pathology Catalysis Dopamine - chemistry Dopamine - metabolism Electron Probe Microanalysis Humans Hydroxydopamines - chemistry Hydroxydopamines - metabolism In Vitro Techniques iron Iron - chemistry Iron - physiology Kinetics Lewy Bodies - metabolism Lewy Bodies - pathology nigrostriatal degeneration Oxidative Stress - physiology Oxidopamine - chemistry Oxidopamine - metabolism Parkinson Disease - pathology Parkinson Disease - physiopathology substantia nigra Triazines - metabolism
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