Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

Background & Aims: Liver fat is increased in type 2 diabetes. We determined whether it is associated with impaired insulin clearance and to what extent insulin resistance, impaired insulin clearance, or secretion contribute to fasting hyperinsulinemia. We also examined whether insulin suppressio...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2008-07, Vol.135 (1), p.122-130
Hauptverfasser:	Kotronen, Anna, Juurinen, Leena, Tiikkainen, Mirja, Vehkavaara, Satu, Yki–Järvinen, Hannele
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adult Body Mass Index Diabetes Mellitus, Type 2 - metabolism Fatty Acids, Nonesterified - blood Fatty Liver - metabolism Fatty Liver - pathology Female Gastroenterology and Hepatology Glucose Clamp Technique Humans Hyperinsulinism - metabolism Insulin - blood Insulin Resistance Liver - metabolism Liver - pathology Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Protons Regression Analysis
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