Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy
We herein report the case of a 67-year-old man who initially presented with fever and hepatosplenomegaly, and soon died of progressive liver failure. The bone marrow was infiltrated with tumor cells showing a variable morphology and macrophages phagocytosing blood cells. The tumor cells were CD2 + ,...
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| Veröffentlicht in: | International journal of hematology 2008-07, Vol.88 (1), p.88-94 |
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| creator | Ohno, Hitoshi Nagata, Norikazu Isoda, Kotaro |
| description | We herein report the case of a 67-year-old man who initially presented with fever and hepatosplenomegaly, and soon died of progressive liver failure. The bone marrow was infiltrated with tumor cells showing a variable morphology and macrophages phagocytosing blood cells. The tumor cells were CD2
+
, CD3
+
, CD4
−
, CD8
+
, CD25
+
, CD56
+/−
, and HLA-DR
+
and exhibited clonal cytogenetic abnormalities. Microscopic examination of the liver postmortem revealed, prominent cellular infiltrates that were confined within the portal area. The infiltrated cells were medium-sized with the CD3
+
, CD4
−
, CD8
+
, CD56
+/−
, and granzyme B
+
phenotype. In situ hybridization detected Epstein–Barr virus (EBV)-encoded RNA-positive cells in the liver and spleen as well as the bone marrow obtained before his death. These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient. |
| doi_str_mv | 10.1007/s12185-008-0122-3 |
| format | Article |
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+
, CD3
+
, CD4
−
, CD8
+
, CD25
+
, CD56
+/−
, and HLA-DR
+
and exhibited clonal cytogenetic abnormalities. Microscopic examination of the liver postmortem revealed, prominent cellular infiltrates that were confined within the portal area. The infiltrated cells were medium-sized with the CD3
+
, CD4
−
, CD8
+
, CD56
+/−
, and granzyme B
+
phenotype. In situ hybridization detected Epstein–Barr virus (EBV)-encoded RNA-positive cells in the liver and spleen as well as the bone marrow obtained before his death. These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-008-0122-3</identifier><identifier>PMID: 18597053</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Antigens, Differentiation - metabolism ; Autopsy ; Biological and medical sciences ; Case Report ; Epstein-Barr virus ; Epstein-Barr Virus Infections - metabolism ; Epstein-Barr Virus Infections - pathology ; Epstein-Barr Virus Infections - virology ; Fatal Outcome ; Hematologic and hematopoietic diseases ; Hematology ; Herpesvirus 4, Human - metabolism ; Humans ; Infectious diseases ; Liver - metabolism ; Liver - pathology ; Liver Failure, Acute - metabolism ; Liver Failure, Acute - pathology ; Liver Failure, Acute - virology ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Liver Neoplasms - secondary ; Liver Neoplasms - virology ; Lymphoma, T-Cell - metabolism ; Lymphoma, T-Cell - pathology ; Lymphoma, T-Cell - virology ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Oncology ; Viral diseases</subject><ispartof>International journal of hematology, 2008-07, Vol.88 (1), p.88-94</ispartof><rights>The Japanese Society of Hematology 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-6585c6e837131219ed3ae0f61b8fecd8a248c16f92ec2985252bb33043b94a83</citedby><cites>FETCH-LOGICAL-c483t-6585c6e837131219ed3ae0f61b8fecd8a248c16f92ec2985252bb33043b94a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-008-0122-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-008-0122-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20543637$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18597053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohno, Hitoshi</creatorcontrib><creatorcontrib>Nagata, Norikazu</creatorcontrib><creatorcontrib>Isoda, Kotaro</creatorcontrib><title>Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>We herein report the case of a 67-year-old man who initially presented with fever and hepatosplenomegaly, and soon died of progressive liver failure. The bone marrow was infiltrated with tumor cells showing a variable morphology and macrophages phagocytosing blood cells. The tumor cells were CD2
+
, CD3
+
, CD4
−
, CD8
+
, CD25
+
, CD56
+/−
, and HLA-DR
+
and exhibited clonal cytogenetic abnormalities. Microscopic examination of the liver postmortem revealed, prominent cellular infiltrates that were confined within the portal area. The infiltrated cells were medium-sized with the CD3
+
, CD4
−
, CD8
+
, CD56
+/−
, and granzyme B
+
phenotype. In situ hybridization detected Epstein–Barr virus (EBV)-encoded RNA-positive cells in the liver and spleen as well as the bone marrow obtained before his death. These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Differentiation - metabolism</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Case Report</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - metabolism</subject><subject>Epstein-Barr Virus Infections - pathology</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Fatal Outcome</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Herpesvirus 4, Human - metabolism</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Failure, Acute - metabolism</subject><subject>Liver Failure, Acute - pathology</subject><subject>Liver Failure, Acute - virology</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - virology</subject><subject>Lymphoma, T-Cell - metabolism</subject><subject>Lymphoma, T-Cell - pathology</subject><subject>Lymphoma, T-Cell - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Viral diseases</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcuKFDEUhoMoTjv6AG4kCLqL5lK5lDsdxgsMuOl9OJVK2RlSF5NUS-_cu_QNfRLTdOOAIMKBHDjffy75EXrK6CtGqX6dGWdGEkoNoYxzIu6hDTNKEqF1cx9taMslkZrRC_Qo51tKmaaNfoguqqrVVIoN-nG95OLD9Ov7z3eQEt6HtGYCOc8uQPE93hLnY8TxMC67eQQcJgw1-jUWvEAJfipv8JLmMUw1reUhxJKqNONvoewqXnYex7D3CS9zKhAxJA84-b2HWAd0BwxrmZd8eIweDBCzf3J-L9H2_fX26iO5-fzh09XbG-IaIwpR0kinvBGaifoBre8FeDoo1pnBu94Ab4xjami5d7w1kkvedULQRnRtA0ZcopentnXrr6vPxY4hH4-Eyc9rtqrlraLN_0FOlVCcyQo-_wu8ndc01RssZ1qYo00VYifIpTnn5Ae7pDBCOlhG7dFOe7LTVjvt0U4rqubZufHajb6_U5z9q8CLMwDZQRwSTC7kPxynshFK6MrxE5drafri092G_57-G3ZWubU</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Ohno, Hitoshi</creator><creator>Nagata, Norikazu</creator><creator>Isoda, Kotaro</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U9</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy</title><author>Ohno, Hitoshi ; Nagata, Norikazu ; Isoda, Kotaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-6585c6e837131219ed3ae0f61b8fecd8a248c16f92ec2985252bb33043b94a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Differentiation - metabolism</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Case Report</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - metabolism</topic><topic>Epstein-Barr Virus Infections - pathology</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Fatal Outcome</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Herpesvirus 4, Human - metabolism</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Failure, Acute - metabolism</topic><topic>Liver Failure, Acute - pathology</topic><topic>Liver Failure, Acute - virology</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - virology</topic><topic>Lymphoma, T-Cell - metabolism</topic><topic>Lymphoma, T-Cell - pathology</topic><topic>Lymphoma, T-Cell - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohno, Hitoshi</creatorcontrib><creatorcontrib>Nagata, Norikazu</creatorcontrib><creatorcontrib>Isoda, Kotaro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Virology and AIDS Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohno, Hitoshi</au><au>Nagata, Norikazu</au><au>Isoda, Kotaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>88</volume><issue>1</issue><spage>88</spage><epage>94</epage><pages>88-94</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>We herein report the case of a 67-year-old man who initially presented with fever and hepatosplenomegaly, and soon died of progressive liver failure. The bone marrow was infiltrated with tumor cells showing a variable morphology and macrophages phagocytosing blood cells. The tumor cells were CD2
+
, CD3
+
, CD4
−
, CD8
+
, CD25
+
, CD56
+/−
, and HLA-DR
+
and exhibited clonal cytogenetic abnormalities. Microscopic examination of the liver postmortem revealed, prominent cellular infiltrates that were confined within the portal area. The infiltrated cells were medium-sized with the CD3
+
, CD4
−
, CD8
+
, CD56
+/−
, and granzyme B
+
phenotype. In situ hybridization detected Epstein–Barr virus (EBV)-encoded RNA-positive cells in the liver and spleen as well as the bone marrow obtained before his death. These observations indicate that EBV-associated T-cell lymphoma expressing cytotoxic proteins was the underlying disorder. Prominent portal involvement was most likely responsible for the fatal clinical outcome of this patient.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>18597053</pmid><doi>10.1007/s12185-008-0122-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-5710 |
| ispartof | International journal of hematology, 2008-07, Vol.88 (1), p.88-94 |
| issn | 0925-5710 1865-3774 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69296048 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Antigens, Differentiation - metabolism Autopsy Biological and medical sciences Case Report Epstein-Barr virus Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Infections - virology Fatal Outcome Hematologic and hematopoietic diseases Hematology Herpesvirus 4, Human - metabolism Humans Infectious diseases Liver - metabolism Liver - pathology Liver Failure, Acute - metabolism Liver Failure, Acute - pathology Liver Failure, Acute - virology Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Liver Neoplasms - virology Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Lymphoma, T-Cell - virology Male Medical sciences Medicine Medicine & Public Health Oncology Viral diseases |
| title | Epstein–Barr virus-associated T-cell lymphoma in an adult patient: prominent infiltrates within the liver portal area revealed by autopsy |
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