Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that sy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1999-10, Vol.24 (2), p.363-376
Hauptverfasser:	Davis, A F, Bai, J, Fasshauer, D, Wolowick, M J, Lewis, J L, Chapman, E R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - physiology Calcium-Binding Proteins Kinetics Membrane Fusion - physiology Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Membranes - metabolism Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Rats Repetitive Sequences, Nucleic Acid Sequence Homology SNARE Proteins Synaptic Vesicles - metabolism Synaptotagmin I Synaptotagmins Vesicular Transport Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!