Does cisplatin chemotherapy decrease the MDP uptake of normal bone? An experimental study

Objective Bone scan is the accepted initial imaging modality for skeletal metastases. Cisplatin is a cell-cycle nonspecific antineoplastic agent used in some chemotherapy regimens. Knowing that platinum reacts with phosphate compounds such as methylenediphosphonic acid (MDP), decreases bone resorpti...

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Veröffentlicht in:	Annals of nuclear medicine 2008-06, Vol.22 (5), p.357-362
Hauptverfasser:	Ozdogan, Ozhan, Ertay, Turkan, Arslan, Gulhan, Sisman, Ali R., Capa Kaya, Gamze, Yilmaz, Osman, Çoker, Canan, Gure, Ataman, Durak, Hatice
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Bone and Bones - diagnostic imaging Bone and Bones - drug effects Bone and Bones - metabolism Cisplatin - administration & dosage Cisplatin - therapeutic use Disease Models, Animal Imaging Male Medicine Medicine & Public Health Metabolic Clearance Rate Nuclear Medicine Original Article Radiology Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Technetium Tc 99m Medronate - pharmacokinetics
Online-Zugang:	Volltext
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