Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers

Abstract Long term facilitation (LTF) of C-fiber-evoked firing of wide dynamic range neurons in the spinal dorsal horn in response to conditioning stimulation (CS) of afferent fibers is a widely studied cellular model of spinal nociceptive sensitization. Although 100 Hz CS of primary afferent fibers...

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Veröffentlicht in:	Neuroscience 2008-07, Vol.154 (4), p.1568-1575
Hauptverfasser:	Haugan, F, Wibrand, K, Fiskå, A, Bramham, C.R, Tjølsen, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arc Biological and medical sciences Cytoskeletal Proteins - biosynthesis Early Growth Response Protein 1 - biosynthesis Electric Stimulation Electrophysiology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation immediate early genes Immunohistochemistry long-term facilitation long-term potentiation Long-Term Potentiation - physiology Nerve Fibers, Unmyelinated - physiology Nerve Tissue Proteins - biosynthesis Neurology nociception Posterior Horn Cells - physiology Proto-Oncogene Proteins c-fos - biosynthesis Rats Rats, Sprague-Dawley Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Up-Regulation Vertebrates: nervous system and sense organs zif268
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