Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?
Chemotherapy and radiation therapy act predominantly through the induction of apoptosis in malignancies. Merkel cell carcinoma, an aggressive malignancy with prominent apoptosis, has proved to be sensitive to both modes to a certain degree. We used immunohistochemical methods to examine 25 Merkel ce...
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| Veröffentlicht in: | Human pathology 1999-11, Vol.30 (11), p.1367-1372 |
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| creator | Feinmesser, Meora Halpern, Marisa Fenig, Eyal Tsabari, Cohava Hodak, Emmilia Sulkes, Jaqueline Brenner, Baruch Okon, Elimelech |
| description | Chemotherapy and radiation therapy act predominantly through the induction of apoptosis in malignancies. Merkel cell carcinoma, an aggressive malignancy with prominent apoptosis, has proved to be sensitive to both modes to a certain degree. We used immunohistochemical methods to examine 25 Merkel cell carcinomas and 8 of their lymph node metastases to assess the status of the antiapoptotic gene
bcl-2 and 2 proapoptotic genes, wild-type
p53 and
bax. All tumors showed prominent bax immunopositivity; 76% were positive for bcl-2, and only 28% were positive for p53, the latter presumably reflecting mutated
p53. No statistically significant relationship was found between tumor immunopositivity and therapy response or survival. The widespread bax immunopositivity and the apparently low rate of
p53 mutations, as suggested by the low rate of p53 immunopositivity, may be related to the presence of prominent apoptosis in Merkel cell carcinoma. The finding of bcl-2 immunopositivity in 76% of the tumors suggests that some of the tumor cells may be resistant to apoptosis-inducing agents. |
| doi_str_mv | 10.1016/S0046-8177(99)90070-9 |
| format | Article |
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bcl-2 and 2 proapoptotic genes, wild-type
p53 and
bax. All tumors showed prominent bax immunopositivity; 76% were positive for bcl-2, and only 28% were positive for p53, the latter presumably reflecting mutated
p53. No statistically significant relationship was found between tumor immunopositivity and therapy response or survival. The widespread bax immunopositivity and the apparently low rate of
p53 mutations, as suggested by the low rate of p53 immunopositivity, may be related to the presence of prominent apoptosis in Merkel cell carcinoma. The finding of bcl-2 immunopositivity in 76% of the tumors suggests that some of the tumor cells may be resistant to apoptosis-inducing agents.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(99)90070-9</identifier><identifier>PMID: 10571519</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Apoptosis ; bcl-2-Associated X Protein ; Biological and medical sciences ; Carcinoma, Merkel Cell - diagnosis ; Carcinoma, Merkel Cell - metabolism ; Carcinoma, Merkel Cell - pathology ; Carcinoma, Merkel Cell - therapy ; Dermatology ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Medical sciences ; Merkel cell carcinoma ; Middle Aged ; proapoptotic and antiapoptotic genes ; Prognosis ; Proto-Oncogene Proteins - biosynthesis ; Proto-Oncogene Proteins c-bcl-2 - biosynthesis ; Sex Factors ; Skin Neoplasms - diagnosis ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy ; treatment ; Treatment Outcome ; Tumor Suppressor Protein p53 - biosynthesis ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Human pathology, 1999-11, Vol.30 (11), p.1367-1372</ispartof><rights>1999</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-70fa9904753201c0e4f763017fdf72f366bbf3e7cb067c096106418bf3e320693</citedby><cites>FETCH-LOGICAL-c419t-70fa9904753201c0e4f763017fdf72f366bbf3e7cb067c096106418bf3e320693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(99)90070-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1213228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10571519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feinmesser, Meora</creatorcontrib><creatorcontrib>Halpern, Marisa</creatorcontrib><creatorcontrib>Fenig, Eyal</creatorcontrib><creatorcontrib>Tsabari, Cohava</creatorcontrib><creatorcontrib>Hodak, Emmilia</creatorcontrib><creatorcontrib>Sulkes, Jaqueline</creatorcontrib><creatorcontrib>Brenner, Baruch</creatorcontrib><creatorcontrib>Okon, Elimelech</creatorcontrib><title>Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Chemotherapy and radiation therapy act predominantly through the induction of apoptosis in malignancies. Merkel cell carcinoma, an aggressive malignancy with prominent apoptosis, has proved to be sensitive to both modes to a certain degree. We used immunohistochemical methods to examine 25 Merkel cell carcinomas and 8 of their lymph node metastases to assess the status of the antiapoptotic gene
bcl-2 and 2 proapoptotic genes, wild-type
p53 and
bax. All tumors showed prominent bax immunopositivity; 76% were positive for bcl-2, and only 28% were positive for p53, the latter presumably reflecting mutated
p53. No statistically significant relationship was found between tumor immunopositivity and therapy response or survival. The widespread bax immunopositivity and the apparently low rate of
p53 mutations, as suggested by the low rate of p53 immunopositivity, may be related to the presence of prominent apoptosis in Merkel cell carcinoma. The finding of bcl-2 immunopositivity in 76% of the tumors suggests that some of the tumor cells may be resistant to apoptosis-inducing agents.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>bcl-2-Associated X Protein</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Merkel Cell - diagnosis</subject><subject>Carcinoma, Merkel Cell - metabolism</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Carcinoma, Merkel Cell - therapy</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Merkel cell carcinoma</subject><subject>Middle Aged</subject><subject>proapoptotic and antiapoptotic genes</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins - biosynthesis</subject><subject>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</subject><subject>Sex Factors</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><subject>treatment</subject><subject>Treatment Outcome</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnROO3oI2hYGKPJlF7qBwo3E9MZf5IxLtQ1oaiLolVQAm1mHmTed6jujrpzAwn57jnccwh5zOAlA8ZffQZoedUzIZ5L-UICCKjkHbJhXVNXfSPru2TzBzkhD1L6AcBY13b3yQmDTrCOyQ25ubhaIqbkgqfB0vwdqV7CkkNyqYo46YwjDd6Eb-gx0cFMVX1GB311RrUf6dI11Hn6EeNPnKjBqRw6GufDrF_Trfar4jUtFqMzmeaIOs_oMy2eS_AJ9ypmct4ZPdGwyybMeP6Q3LN6SvjoeJ-Sr28vvmzfV5ef3n3YvrmsTMtkrgRYLSW0ouwMzAC2VvAGmLCjFbVtOB8G26AwA3BhQHIGvGX9-lYGuGxOybOD7hLDrx2mrGaX1i20x7BListasl7yAnYH0MSQUkSrluhmHa8VA7X2ofZ9qDVsJaXa96FWgydHg90w4_jP1KGAAjw9AjqVBGzU3rj0l6tZU9d9wc4PGJY0fjuMKhmH3pRYI5qsxuD-85NbMy2neQ</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Feinmesser, Meora</creator><creator>Halpern, Marisa</creator><creator>Fenig, Eyal</creator><creator>Tsabari, Cohava</creator><creator>Hodak, Emmilia</creator><creator>Sulkes, Jaqueline</creator><creator>Brenner, Baruch</creator><creator>Okon, Elimelech</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?</title><author>Feinmesser, Meora ; Halpern, Marisa ; Fenig, Eyal ; Tsabari, Cohava ; Hodak, Emmilia ; Sulkes, Jaqueline ; Brenner, Baruch ; Okon, Elimelech</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-70fa9904753201c0e4f763017fdf72f366bbf3e7cb067c096106418bf3e320693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>bcl-2-Associated X Protein</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Merkel Cell - diagnosis</topic><topic>Carcinoma, Merkel Cell - metabolism</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Carcinoma, Merkel Cell - therapy</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Merkel cell carcinoma</topic><topic>Middle Aged</topic><topic>proapoptotic and antiapoptotic genes</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins - biosynthesis</topic><topic>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</topic><topic>Sex Factors</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - therapy</topic><topic>treatment</topic><topic>Treatment Outcome</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feinmesser, Meora</creatorcontrib><creatorcontrib>Halpern, Marisa</creatorcontrib><creatorcontrib>Fenig, Eyal</creatorcontrib><creatorcontrib>Tsabari, Cohava</creatorcontrib><creatorcontrib>Hodak, Emmilia</creatorcontrib><creatorcontrib>Sulkes, Jaqueline</creatorcontrib><creatorcontrib>Brenner, Baruch</creatorcontrib><creatorcontrib>Okon, Elimelech</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feinmesser, Meora</au><au>Halpern, Marisa</au><au>Fenig, Eyal</au><au>Tsabari, Cohava</au><au>Hodak, Emmilia</au><au>Sulkes, Jaqueline</au><au>Brenner, Baruch</au><au>Okon, Elimelech</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>30</volume><issue>11</issue><spage>1367</spage><epage>1372</epage><pages>1367-1372</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Chemotherapy and radiation therapy act predominantly through the induction of apoptosis in malignancies. Merkel cell carcinoma, an aggressive malignancy with prominent apoptosis, has proved to be sensitive to both modes to a certain degree. We used immunohistochemical methods to examine 25 Merkel cell carcinomas and 8 of their lymph node metastases to assess the status of the antiapoptotic gene
bcl-2 and 2 proapoptotic genes, wild-type
p53 and
bax. All tumors showed prominent bax immunopositivity; 76% were positive for bcl-2, and only 28% were positive for p53, the latter presumably reflecting mutated
p53. No statistically significant relationship was found between tumor immunopositivity and therapy response or survival. The widespread bax immunopositivity and the apparently low rate of
p53 mutations, as suggested by the low rate of p53 immunopositivity, may be related to the presence of prominent apoptosis in Merkel cell carcinoma. The finding of bcl-2 immunopositivity in 76% of the tumors suggests that some of the tumor cells may be resistant to apoptosis-inducing agents.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10571519</pmid><doi>10.1016/S0046-8177(99)90070-9</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Apoptosis bcl-2-Associated X Protein Biological and medical sciences Carcinoma, Merkel Cell - diagnosis Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - therapy Dermatology Female Humans Immunohistochemistry Lymphatic Metastasis Male Medical sciences Merkel cell carcinoma Middle Aged proapoptotic and antiapoptotic genes Prognosis Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins c-bcl-2 - biosynthesis Sex Factors Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - therapy treatment Treatment Outcome Tumor Suppressor Protein p53 - biosynthesis Tumors of the skin and soft tissue. Premalignant lesions |
| title | Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome? |
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