Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms
Spontaneously hypertensive rats (SHR) are characterized by enhanced nifedipine-sensitive component of sympathetic vasoconstriction. Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult un...
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| Veröffentlicht in: | Physiological research 2008-01, Vol.57 (3), p.495-498 |
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| creator | Zicha, J Dobešová, Z Kunes, J |
| description | Spontaneously hypertensive rats (SHR) are characterized by enhanced nifedipine-sensitive component of sympathetic vasoconstriction. Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipine-sensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal. |
| doi_str_mv | 10.33549/physiolres.931615 |
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Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipine-sensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.931615</identifier><identifier>PMID: 18597587</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Age Factors ; Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Animals ; Antihypertensive Agents - administration & dosage ; Blood Pressure - drug effects ; Captopril - administration & dosage ; Children & youth ; Disease Models, Animal ; Drug Administration Schedule ; Hypertension ; Hypertension - drug therapy ; Hypertension - physiopathology ; Male ; Nifedipine - pharmacology ; Rats ; Rats, Inbred SHR ; Rodents ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiopathology ; Vasoconstriction - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Physiological research, 2008-01, Vol.57 (3), p.495-498</ispartof><rights>Copyright Institute of Physiology 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5fe93f5716a7215fc4d6290d39f44a7f6035fdaf57a65a438bbd56e1a65daddf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18597587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zicha, J</creatorcontrib><creatorcontrib>Dobešová, Z</creatorcontrib><creatorcontrib>Kunes, J</creatorcontrib><title>Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Spontaneously hypertensive rats (SHR) are characterized by enhanced nifedipine-sensitive component of sympathetic vasoconstriction. Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipine-sensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.</description><subject>Age Factors</subject><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Animals</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Blood Pressure - drug effects</subject><subject>Captopril - administration & dosage</subject><subject>Children & youth</subject><subject>Disease Models, Animal</subject><subject>Drug Administration Schedule</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Nifedipine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rodents</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1r3DAQhkVJ6W62_QM9BJFDbk71YX31VpYmG1goNOnZyNaI9WJbjiQf9t9X7S4EchpmeN6XmXkR-krJPeeiNt_mwyn1YYiQ7g2nkooPaE01YZUxil-hNdGSVbomeoWuUzoSwhRR_BNaUS2MElqt0bi3GXA7hODwXIzSEgFHcEuX-zDhfsLPu984Le0RugwO54BztFPqYcq4s3MOc-yHMgObx3-zojiFJR--4zmk1LcD4BG6g536NKbP6KO3Q4Ivl7pBfx5-vmx31f7X49P2x77quGK5Eh4M90JRaRWjwne1k8wQx42va6u8JFx4ZwthpbA1123rhARaOmed83yD7s6-cwyvC6TcjH3qYBjsBGFJjTRMm1qRAt6-A49hiVPZrWGUUSWpNgViZ6iL5aQIvik3jzaeGkqa_0k0b0k05ySK6ObivLQjuDfJ5fX8L2RJieY</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Zicha, J</creator><creator>Dobešová, Z</creator><creator>Kunes, J</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms</title><author>Zicha, J ; 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Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipine-sensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>18597587</pmid><doi>10.33549/physiolres.931615</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Angiotensin-Converting Enzyme Inhibitors - administration & dosage Animals Antihypertensive Agents - administration & dosage Blood Pressure - drug effects Captopril - administration & dosage Children & youth Disease Models, Animal Drug Administration Schedule Hypertension Hypertension - drug therapy Hypertension - physiopathology Male Nifedipine - pharmacology Rats Rats, Inbred SHR Rodents Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Vasoconstriction - drug effects Vasodilator Agents - pharmacology |
| title | Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms |
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