Trithiocarbonates as a Novel Class of HDAC Inhibitors: SAR Studies, Isoenzyme Selectivity, and Pharmacological Profiles

Inhibitors of histone deacetylases (HDAC) are currently developed for the treatment of cancer. These include compounds with a sulfur containing head group like depsipeptide, alkylthiols, thiocarboxylates, and trithiocarbonates with a carbonyl group in the α-position. In the present investigation, we...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-07, Vol.51 (13), p.3985-4001
Hauptverfasser:	Dehmel, Florian, Weinbrenner, Steffen, Julius, Heiko, Ciossek, Thomas, Maier, Thomas, Stengel, Thomas, Fettis, Kamal, Burkhardt, Carmen, Wieland, Heike, Beckers, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic agents Biological and medical sciences Cell Cycle - drug effects Cell Survival - drug effects Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General aspects Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones - metabolism Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Kinetics Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship Thiones - chemical synthesis Thiones - chemistry Thiones - pharmacology
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